Lipid signaling cascades of orexin/hypocretin receptors

Biochimie

Volumn 96, Issue 1, 2014, Pages 158-165

  Kukkonen, Jyrki P ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Endocannabinoid; Hypocretin; Ion fluxes; Orexin; Phospholipase

Indexed keywords

CALCIUM; ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR; LIPID; OREXIN RECEPTOR; PHOSPHOLIPASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PHOSPHOLIPASE D;

CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HEK293; CELL TYPE; CENTRAL NERVOUS SYSTEM; CHO CELL; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; MITOCHONDRIAL MEMBRANE; REVIEW; SIGNAL TRANSDUCTION;

2-AG; 2-ARACHIDONOYLGLYCEROL; A CPLA(2)Α/Ζ INHIBITOR; A NCX INHIBITOR; A PLC INHIBITOR; AA; ANANDAMIDE; ARACHIDONIC ACID; CENTRAL NERVOUS SYSTEM; CNS; CPLA(2) AND IPLA(2); CYTOSOLIC (CA(2+)-DEPENDENT) AND INTRACELLULAR (CA(2+)-INDEPENDENT) PLA(2), RESPECTIVELY; DAG; DAG LIPASE; DAGL; DIACYLGLYCEROL; DIOCTANOYLGLYCEROL; DOG; ENDOCANNABINOID; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; G-PROTEIN-COUPLED RECEPTOR; GLYCEROPHOSPHOLIPID; GPCR; GPL; HYPOCRETIN; INOSITOL-1,4,5-TRISPHOSPHATE; ION FLUXES; IP(3); KB-R7943; LYSO(GLYCERO)PHOSPHOLIPID; LYSOGPL; LYSOPA; LYSOPHOSPHATIDIC ACID; MAFP; METHYL ARACHIDONYL FLUOROPHOSPHONATE; N-ACYL-PHOSPHATIDYLETHANOLAMINE; N-ARACHIDONOYLETHANOLAMINE; NAPE; NON-SELECTIVE CATION CHANNEL; NSCC; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OX(1); OX(2); PA; PC; PC-PLC; PC-SPECIFIC PLC; PDK1; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE; PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE; PHOSPHATIDYLINOSITOLMONOPHOSPHATE; PHOSPHATIDYLINOSITOLS (INCLUDING DIFFERENTIALLY PHOSPHORYLATED SPECIES PI, PIP, PIP(2) AND PIP(3)); PHOSPHOINOSITIDE-3-KINASE; PHOSPHOINOSITIDE-DEPENDENT KINASE 1; PHOSPHOLIPASE; PHOSPHOLIPASE A(1), A(2), B, C AND D, RESPECTIVELY; PI; PI3K; PIP; PIP(2); PIP(3); PIS; PKB, PKC AND PKD; PLA(1), PLA(2), PLB, PLC AND PLD; PROTEIN KINASE B, C AND D, RESPECTIVELY; PYRROPHENONE; TRANSIENT RECEPTOR POTENTIAL (CHANNEL); TRP (CHANNEL); U73122;

ANIMALS; CALCIUM SIGNALING; ENDOCANNABINOIDS; HUMANS; LIPID METABOLISM; OREXIN RECEPTORS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOLIPASES;

EID: 84890552439     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.06.015     Document Type: Review

References (103)

1. J.P. Kukkonen Recent progress in orexin/hypocretin physiology and pharmacology Biomol. Concepts 3 2012 447 463
2. J.P. Kukkonen Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 Am. J. Physiol. Cell. Physiol. 301 2013 C2 C32
3. J.P. Kukkonen, and C.S. Leonard Orexin/hypocretin receptor signalling cascades Br. J. Pharmacol. 2013 submitted for publication
4. C.S. Leonard, and J.P. Kukkonen Orexin/hypocretin receptor signalling: A functional perspective Br. J. Pharmacol. 2013 submitted for publication
5. J.P. Kukkonen A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels Cell Calcium 50 2011 9 26
6. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma, and M. Yanagisawa Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 573 585
7. D. Smart, J.C. Jerman, S.J. Brough, S.L. Rushton, P.R. Murdock, F. Jewitt, N.A. Elshourbagy, C.E. Ellis, D.N. Middlemiss, and F. Brown Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR Br. J. Pharmacol. 128 1999 1 3
8. 2+ influx pathway necessary for coupling to phospholipase C J. Biol. Chem. 275 2000 30806 30812
9. 2+ influx and ERK, Biochem Biophys. Res. Commun. 353 2007 475 480
10. 2+ channels NeuroReport 12 2001 2017 2020
11. E.A. Dennis, J. Cao, Y.H. Hsu, V. Magrioti, and G. Kokotos Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Chem. Rev. 111 2011 6130 6185
12. M. Ghosh, D.E. Tucker, S.A. Burchett, and C.C. Leslie Properties of the group IV phospholipase A2 family Prog. Lipid Res. 45 2006 487 510
13. S. Akiba, and T. Sato Cellular function of calcium-independent phospholipase A2 Biol. Pharm. Bull. 27 2004 1174 1178
14. J. Balsinde, and M.A. Balboa Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells Cell. Signal. 17 2005 1052 1062
15. 1 orexin receptors Br. J. Pharmacol. 159 2010 212 221
16. P.M. Turunen, J. Putula, and J.P. Kukkonen Filtration assay for arachidonic acid release Anal. Biochem. 407 2010 233 236
17. 1 orexin/hypocretin receptor signaling via arachidonic acid and endocannabinoid release Mol. Pharmacol. 82 2012 156 167
18. M. Ghosh, R. Loper, F. Ghomashchi, D.E. Tucker, J.V. Bonventre, M.H. Gelb, and C.C. Leslie Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts J. Biol. Chem. 282 2007 11676 11686
19. 1 orexin receptors Biochem. Biophys. Res. Commun. 385 2009 408 412
20. G.M. Jenkins, and M.A. Frohman Phospholipase D: a lipid centric review Cell. Mol. Life Sci. 62 2005 2305 2316
21. H. Huang, and M.A. Frohman Lipid signaling on the mitochondrial surface Biochim. Biophys. Acta 1791 2009 839 844
22. Y. Okamoto, K. Tsuboi, and N. Ueda Enzymatic formation of anandamide Vitam. Horm. 81 2009 1 24
23. C. Dall'Armi, A. Hurtado-Lorenzo, H. Tian, E. Morel, A. Nezu, R.B. Chan, W.H. Yu, K.S. Robinson, O. Yeku, S.A. Small, K. Duff, M.A. Frohman, M.R. Wenk, A. Yamamoto, and G. Di Paolo The phospholipase D1 pathway modulates macroautophagy Nat. Commun. 1 2010 142
24. T.G. Oliveira, R.B. Chan, H. Tian, M. Laredo, G. Shui, A. Staniszewski, H. Zhang, L. Wang, T.W. Kim, K.E. Duff, M.R. Wenk, O. Arancio, and G. Di Paolo Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits J. Neurosci. 30 2010 16419 16428
25. L. Monovich, B. Mugrage, E. Quadros, K. Toscano, R. Tommasi, S. LaVoie, E. Liu, Z. Du, D. LaSala, W. Boyar, and P. Steed Optimization of halopemide for phospholipase D2 inhibition Bioorg. Med. Chem. Lett. 17 2007 2310 2311
26. W. Su, O. Yeku, S. Olepu, A. Genna, J.S. Park, H. Ren, G. Du, M.H. Gelb, A.J. Morris, and M.A. Frohman 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis Mol. Pharmacol. 75 2009 437 446
27. S.A. Scott, P.E. Selvy, J.R. Buck, H.P. Cho, T.L. Criswell, A.L. Thomas, M.D. Armstrong, C.L. Arteaga, C.W. Lindsley, and H.A. Brown Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness Nat. Chem. Biol. 5 2009 108 117
28. 1 orexin/hypocretin receptor activation of phospholipase D Br. J. Pharmacol. 165 2012 1109 1123
29. T. Holmqvist, K.E.O. Åkerman, and J.P. Kukkonen Orexin signaling in recombinant neuron-like cells FEBS Lett. 526 2002 11 14
30. J. Tang, J. Chen, M. Ramanjaneya, A. Punn, A.C. Conner, and H.S. Randeva The signalling profile of recombinant human orexin-2 receptor Cell. Signal. 20 2008 1651 1661
31. 1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras Neurosci. Lett. 506 2012 111 115
32. G. Mazzocchi, L.K. Malendowicz, F. Aragona, P. Rebuffat, L. Gottardo, and G.G. Nussdorfer Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B J. Clin. Endocrinol. Metab. 86 2001 4818 4821
33. H.S. Randeva, E. Karteris, D. Grammatopoulos, and E.W. Hillhouse Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis J. Clin. Endocrinol. Metab. 86 2001 4808 4813
34. E. Karteris, J. Chen, and H.S. Randeva Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system J. Clin. Endocrinol. Metab. 89 2004 1957 1962
35. E. Karteris, R.J. Machado, J. Chen, S. Zervou, E.W. Hillhouse, and H.S. Randeva Food deprivation differentially modulates orexin receptor expression and signalling in the rat hypothalamus and adrenal cortex Am. J. Physiol. Endocrinol. Metab. 288 2005 E1089 E1100
36. 2+ influx Br. J. Pharmacol. 150 2007 97 104
37. A.N. van den Pol, X.B. Gao, K. Obrietan, T.S. Kilduff, and A.B. Belousov Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin J. Neurosci. 18 1998 7962 7971
38. 2+ signaling in dopamine neurons of the ventral tegmental area NeuroReport 12 2001 1885 1889
39. B. Yang, W.K. Samson, and A.V. Ferguson Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C J. Neurosci. 23 2003 6215 6222
40. B. Yang, and A.V. Ferguson Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances J. Neurophysiol. 89 2003 2167 2175
41. K.A. Kohlmeier, T. Inoue, and C.S. Leonard Hypocretin/orexin peptide signalling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum J. Neurophysiol. 3 2004 3
42. 2+ transients mediated by L-type calcium channels J. Neurophysiol. 100 2008 2265 2281
43. 2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors J. Neurophysiol. 104 2010 2052 2062
44. Y. Sasaki, Y. Asaoka, and Y. Nishizuka Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids. Subspecies difference FEBS Lett. 320 1993 47 51
45. Y. Nishizuka Protein kinase C and lipid signaling for sustained cellular responses FASEB J. 9 1995 484 496
46. K. Kashiwagi, Y. Shirai, M. Kuriyama, N. Sakai, and N. Saito Importance of C1B domain for lipid messenger-induced targeting of protein kinase C J. Biol. Chem. 277 2002 18037 18045
47. R. Lopez-Nicolas, M.J. Lopez-Andreo, C. Marin-Vicente, J.C. Gomez-Fernandez, and S. Corbalan-Garcia Molecular mechanisms of PKCalpha localization and activation by arachidonic acid. The C2 domain also plays a role J. Mol. Biol. 357 2006 1105 1120
48. X.P. Huang, Y. Pi, A.J. Lokuta, M.L. Greaser, and J.W. Walker Arachidonic acid stimulates protein kinase C-epsilon redistribution in heart cells J. Cell Sci. 110 Pt 14 1997 1625 1634
49. C. Luberto, and Y.A. Hannun Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem. 273 1998 14550 14559
50. A. Bai, G.P. Meier, Y. Wang, C. Luberto, Y.A. Hannun, and D. Zhou Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells J. Pharmacol. Exp. Ther. 309 2004 1051 1059
51. R. Sadja, N. Alagem, and E. Reuveny Gating of GIRK channels: details of an intricate, membrane-delimited signaling complex Neuron 39 2003 9 12
52. H. Hibino, A. Inanobe, K. Furutani, S. Murakami, I. Findlay, and Y. Kurachi Inwardly rectifying potassium channels: their structure, function, and physiological roles Physiol. Rev. 90 2010 291 366
53. C. Luscher, and P.A. Slesinger Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease Nat. Rev. Neurosci. 11 2010 301 315
54. Q.V. Hoang, D. Bajic, M. Yanagisawa, S. Nakajima, and Y. Nakajima Effects of orexin (hypocretin) on GIRK channels J. Neurophysiol. 90 2003 693 702
55. Q.V. Hoang, P. Zhao, S. Nakajima, and Y. Nakajima Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons J. Neurophysiol. 92 2004 3183 3191
56. M. Wu, L. Zaborszky, T. Hajszan, A.N. van den Pol, and M. Alreja Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons J. Neurosci. 24 2004 3527 3536
57. H. Huang, P. Ghosh, and A.N. van den Pol Prefrontal cortex-projecting glutamatergic thalamic paraventricular nucleus-excited by hypocretin: a feedforward circuit that may enhance cognitive arousal J. Neurophysiol. 95 2006 1656 1668
58. J. Zhang, B. Li, L. Yu, Y.C. He, H.Z. Li, J.N. Zhu, and J.J. Wang A role for orexin in central vestibular motor control Neuron 69 2011 793 804
59. H. Meves Arachidonic acid and ion channels: an update Br. J. Pharmacol. 155 2008 4 16
60. B. Nilius, G. Owsianik, T. Voets, and J.A. Peters Transient receptor potential cation channels in disease Physiol. Rev. 87 2007 165 217
61. K. Venkatachalam, and C. Montell TRP channels Annu. Rev. Biochem. 76 2007 387 417
62. 2+ entry in endothelial cells J. Biol. Chem. 279 2004 20941 20949
63. S.N. Saleh, A.P. Albert, C.M. Peppiatt-Wildman, and W.A. Large Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes J. Physiol. 586 2008 2463 2476
64. S.N. Saleh, A.P. Albert, and W.A. Large Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes J. Physiol. 587 2009 5361 5375
65. 2+ sensitivity of the nonselective cation channel TRPM4 J. Biol. Chem. 280 2005 6423 6433
66. S. Earley, S.V. Straub, and J.E. Brayden Protein kinase C regulates vascular myogenic tone through activation of TRPM4 Am. J. Physiol. Heart Circ. Physiol. 292 2007 H2613 H2622
67. G. Cao, S. Thebault, J. van der Wijst, A. van der Kemp, E. Lasonder, R.J. Bindels, and J.G. Hoenderop RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain Curr. Biol. 18 2008 168 176
68. 2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells J. Hypertens. 27 2009 155 166
69. R. Crnich, G.C. Amberg, M.D. Leo, A.L. Gonzales, M.M. Tamkun, J.H. Jaggar, and S. Earley Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells Am. J. Physiol. Cell. Physiol. 299 2010 C682 C694
70. Z.I. Garcia, A. Bruhl, A.L. Gonzales, and S. Earley Basal protein kinase Cdelta activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells Channels (Austin) 5 2011 210 214
71. M.A. Rampino, and S.A. Nawy Relief of Mg(2)(+)-dependent inhibition of TRPM1 by PKCalpha at the rod bipolar cell synapse J. Neurosci. 31 2011 13596 13603
72. 2+ entry by protein kinase C and calmodulin Proc. Natl. Acad. Sci. U. S. A 98 2001 3600 3605
73. 2+ entry in HEK 293 cells transiently expressing human TRPV4 Br. J. Pharmacol. 140 2003 413 421
74. G. Bhave, H.J. Hu, K.S. Glauner, W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.W.t. Gereau Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) Proc. Natl. Acad. Sci. U. S. A 100 2003 12480 12485
75. C. Morenilla-Palao, R. Planells-Cases, N. Garcia-Sanz, and A. Ferrer-Montiel Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity J. Biol. Chem. 279 2004 25665 25672
76. D. Gkika, C.N. Topala, Q. Chang, N. Picard, S. Thebault, P. Houillier, J.G. Hoenderop, and R.J. Bindels Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5 EMBO J. 25 2006 4707 4716
77. E. Lizanecz, Z. Bagi, E.T. Pasztor, Z. Papp, I. Edes, N. Kedei, P.M. Blumberg, and A. Toth Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1 Mol. Pharmacol. 69 2006 1015 1023
78. S.K. Cha, T. Wu, and C.L. Huang Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5 Am. J. Physiol. Ren. Physiol. 294 2008 F1212 F1221
79. D.S. Cao, S.Q. Yu, and L.S. Premkumar Modulation of transient receptor potential vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C Mol. Pain 5 2009 5
80. 2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation FASEB J. 24 2010 425 435
81. A.J. Streets, A.J. Needham, S.K. Gill, and A.C. Ong Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity Mol. Biol. Cell 21 2010 3853 3865
82. 2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA) J. Biol. Chem. 284 2009 14788 14795
83. C. Nelson, and M.D. Glitsch Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells J. Biol. Chem. 287 2012 6326 6335
84. 2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells J. Neurosci. 26 2006 10658 10666
85. L.M. Louhivuori, L. Jansson, T. Nordstrom, G. Bart, J. Nasman, and K.E. Akerman Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway Cell Calcium 48 2010 114 123
86. 2+ entry: evidence for involvement of TRPC channels and protein kinase C regulation J. Biol. Chem. 280 2005 1771 1781
87. P. Eder, R. Schindl, C. Romanin, and K. Groschner Protein-protein interactions in TRPC channel complexes W.B. Liedtke, S. Heller, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades 2007 Boca Raton (FL)
88. 2+ transport Biochem. J. 406 2007 365 382
89. M. Wu, Z. Zhang, C. Leranth, C. Xu, A.N. van den Pol, and M. Alreja Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition J. Neurosci. 22 2002 7754 7765
90. D. Burdakov, B. Liss, and F.M. Ashcroft Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger J. Neurosci. 23 2003 4951 4957
91. C. Acuna-Goycolea, and A.N. van den Pol Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin J. Neurosci. 29 2009 1503 1513
92. 2+ exchange inhibitors Mol. Cell. Biochem. 259 2004 157 161
93. 2+ exchange inhibitor KB-R7943 potently blocks TRPC channels, Biochem Biophys. Res. Commun. 361 2007 230 236
94. T. Bisogno, F. Howell, G. Williams, A. Minassi, M.G. Cascio, A. Ligresti, I. Matias, A. Schiano-Moriello, P. Paul, E.J. Williams, U. Gangadharan, C. Hobbs, V. Di Marzo, and P. Doherty Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain J. Cell Biol. 163 2003 463 468
95. M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe Endocannabinoid-mediated control of synaptic transmission Physiol. Rev. 89 2009 309 380
96. S. Rom, and Y. Persidsky Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation J. Neuroimmune. Pharmacol. 8 2013 608 620
97. 1 orexin receptor coexpression Mol. Pharmacol. 83 2013 621 632
98. S. Haj-Dahmane, and R.Y. Shen The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling J. Neurosci. 25 2005 896 905
99. Y.C. Ho, H.J. Lee, L.W. Tung, Y.Y. Liao, S.Y. Fu, S.F. Teng, H.T. Liao, K. Mackie, and L.C. Chiou Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition J. Neurosci. 31 2011 14600 14610
100. M.P. Wymann, M. Zvelebil, and M. Laffargue Phosphoinositide 3-kinase signalling-which way to target? Trends Pharmacol. Sci. 24 2003 366 376
101. E. Göncz, M.Z. Strowski, C. Grotzinger, K.W. Nowak, P. Kaczmarek, M. Sassek, S. Mergler, B.F. El-Zayat, M. Theodoropoulou, G.K. Stalla, B. Wiedenmann, and U. Plockinger Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway Endocrinology 149 2008 1618 1626
102. M. Skrzypski, T.T. Le, P. Kaczmarek, E. Pruszynska-Oszmalek, P. Pietrzak, D. Szczepankiewicz, P.A. Kolodziejski, M. Sassek, A. Arafat, B. Wiedenmann, K.W. Nowak, and M.Z. Strowski Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes Diabetologia 54 2011 1841 1852
103. 1 receptor signaling Mol. Endocrinol. 20 2006 80 99