Arachidonic acid release mediated by OX 1 orexin receptors

British Journal of Pharmacology

Volumn 159, Issue 1, 2010, Pages 212-221

  Turunen, Pauli M ^a   Ekholm, Marie E ^b   Somerharju, Pentti ^c   Kukkonen, Jyrki P ^a,b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF HELSINKI   (Finland)

^d MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

Arachidonic acid; Ca 2+ influx; CPLA 2; Hypocretin; IPLA 2; Orexin; OX 1 receptor; Phospholipase A 2; PLA 2

Indexed keywords

ARACHIDONIC ACID; BROMOENOL LACTONE; FLUOROPHOSPHATE; METHYLARACHIDONYLFLUOROPHOSPHONATE; MITOGEN ACTIVATED PROTEIN KINASE; OREXIN 1 RECEPTOR; OREXIN A; OREXIN B; PHOSPHOLIPASE A2; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHINESE HAMSTER; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; OVARY CELL; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACID; CALCIUM SIGNALING; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; PHOSPHOLIPASES A2; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SIGNAL TRANSDUCTION;

EID: 74549114708     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00535.x     Document Type: Article

References (41)

1. Akiba S, Sato T (2004). Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull 27 : 1174 1178.
2. Alexander SP, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC). Br J Pharmacol 153 (Suppl. 2 S1 209.
3. 2 receptors by orexin peptides. J Pharmacol Exp Ther 305 : 507 514.
4. 1 receptor signaling. Mol Endocrinol 20 : 80 99.
5. 1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress- activated protein kinase. J Biol Chem 281 : 834 842.
6. 2 in activated cells. Cell Signal 17 : 1052 1062.
7. 2 structure/function, mechanism, and signaling. J Lipid Res 50 : S237 S242.
8. Delmas P, Coste B, Gamper N, Shapiro MS (2005). Phosphoinositide lipid second messengers: new paradigms for calcium channel modulation. Neuron 47 : 179 182.
9. 2+ oscillations induced by ATP in Chinese hamster ovary cells. J Biol Chem 272 : 17367 17375.
10. 2+ influx and ERK. Biochem Biophys Res Commun 353 : 475 480. (Pubitemid 46014588)
11. 2 family. Prog Lipid Res 45 : 487 510.
12. Holmqvist T, Åkerman KEO, Kukkonen JP (2002). Orexin signaling in recombinant neuron-like cells. FEBS Lett 526 : 11 14.
13. 1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. J Biol Chem 280 : 6570 6579.
14. 2β. Implications for structure and function. J Biol Chem 276 : 7129 7135.
15. 2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem 277 : 32807 32814.
16. 2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279 : 48968 48975.
17. 2+ influx. Br J Pharmacol 150 : 97 104. (Pubitemid 46094674)
18. 1 orexin/hypocretin receptors. Cell Mol Life Sci 65 : 1948 1956.
19. Kenakin T (1995). Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16 : 232 238.
20. Kenakin T (2003). Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol Sci 24 : 346 354.
21. Kukkonen JP (2004). Regulation of receptor-coupling to (multiple) G-proteins. A challenge for basic research and drug discovery. Receptors Channels 10 : 167 183.
22. 2+ channels. Neuroreport 12 : 2017 2020.
23. Kukkonen JP, Åkerman KEO (2005). Intracellular signal pathways utilized by the hypocretin/orexin receptors. In : de Lecea L, Sutcliffe JG (eds). Hypocretins as Integrators of Physiological Signals. Springer Science+Business Media : Berlin, pp. 221 231.
24. 2A-adrenoceptor responses in HEL 92.1.7 cells. Br J Pharmacol 132 : 1477 1484.
25. Kukkonen JP, Holmqvist T, Ammoun S, Åkerman KE (2002). Functions of the orexinergic/hypocretinergic system. Am J Physiol Cell Physiol 283 : C1567 C1591.
26. 2+ entry: evidence for involvement of trpc channels and protein kinase C regulation. J Biol Chem 280 : 1771 1781.
27. 2. Prostaglandins Leukot Essent Fatty Acids 70 : 373 376.
28. 2+ influx pathway necessary for coupling to phospholipase C. J Biol Chem 275 : 30806 30812.
29. Meves H (2008). Arachidonic acid and ion channels: an update. Br J Pharmacol 155 : 4 16.
30. Milasta S, Evans NA, Ormiston L, Wilson S, Lefkowitz RJ, Milligan G (2005). The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. Biochem J 387 : 573 584.
31. Montell C (2005). The TRP superfamily of cation channels. Sci STKE 2005 : re3.
32. 2-alpha. J Biol Chem 279 : 25024 25038.
33. 2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. J Neurosci 26 : 10658 10666.
34. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001). Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab 86 : 4808 4813.
35. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H et al. (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 : 573 585.
36. 2 superfamily and its group numbering system. Biochim Biophys Acta 1761 : 1246 1259.
37. Shenoy SK, Lefkowitz RJ (2005). Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Sci STKE 2005 : cm14.
38. Shuttleworth TJ, Thompson JL, Mignen O (2004). ARC channels: a novel pathway for receptor-activated calcium entry. Physiology 19 : 355 361.
39. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488 : 1 19.
40. Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA et al. (2001). SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132 : 1179 1182.
41. 2: a new kid on the block. Clin Chem 52 : 1645 1650.