Titers of Herpes Simplex Virus Type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 38, Issue 4, 2014, Pages 741-745

  Mancuso, Roberta ^a   Baglio, Francesca ^a   Cabinio, Monia ^a,b   Calabrese, Elena ^a   Hernis, Ambra ^a   Nemni, Raffaello ^a,b   Clerici, Mario ^a,b  

^a IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Alzheimer's disease; HSV 1; Humoral immunity; Magnetic resonance imaging

Indexed keywords

HERPES SIMPLEX VIRUS 1 ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY TITER; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GRAY MATTER; HERPES SIMPLEX VIRUS 1; HUMAN; HUMORAL IMMUNITY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; PRIORITY JOURNAL; SEROPREVALENCE; TEMPORAL CORTEX; VOXEL BASED MORPHOMETRY;

ALZHEIMER'S DISEASE; HSV-1; HUMORAL IMMUNITY; MAGNETIC RESONANCE IMAGING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES, VIRAL; CEREBRAL CORTEX; FEMALE; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED;

EID: 84890539671     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130977     Document Type: Article

References (31)

1. Jamieson GA, Maitland NJ, Wilcock GK, Craske J, Itzhaki RF (1991) Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains. J Med Virol 33, 224-227.
2. Jamieson GA, Maitland NJ, Wilcock GK, Yates CM, Itzhaki RF (1992) Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type. J Pathol 167, 365-368.
3. Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA (1997) Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Lancet 349, 241-244.
4. Lin WR, Wozniak MA, Cooper RJ, Wilcock GK, Itzhaki RF (2002) Herpesviruses in brain and Alzheimer's disease. J Pathol 197, 395-402.
5. WozniakMA, Shipley SJ, CombrinckM, Wilcock GK, Itzhaki RF (2005) Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients. J Med Virol 75, 300-306.
6. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB (2007) Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci Lett 429, 95-100.
7. Wozniak MA, Frost AL, Itzhaki RF (2009) Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. J Alzheimers Dis 16, 341-350.
8. Letenneur L, Peres K, Fleury H, Garrigue I, Barberger-Gateau P, Helmer C, Orgogozo JM, Gauthier S, Dartigues JF (2008) Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: A population-based cohort study. PLoS One 3, e3637.
9. Itzhaki RF, Wozniak M, Dobson C, Lin WR (1998) ApoEviral interactions. Nat Med, 4, 1344.
10. Damasio AR, Van Hoesen GW (1985) The limbic system and the localisation of herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 48, 297-301.
11. Kennedy PG, Chaudhuri A (2002) Herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 73, 237-238.
12. Sokolov AA, Reincke M (2012) Herpes simplex encephalitis affecting the entire limbic system. Mayo Clin Proc 87, e69.
13. Satpute-Krishnan P, DeGiorgis JA, Bearer EL (2003) Fast anterograde transport of herpes simplex virus: Role for the amyloid precursor protein of Alzheimer's disease. Aging Cell 2, 305-318.
14. Wozniak MA, Frost AL, Preston CM, Itzhaki RF (2011) Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One 6, e25152.
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
16. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 263-269.
17. Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Muller-Hermelink HK, Steinmann GG (1984) Admission criteria for immunogerontological studies in man: The SENIEUR protocol. Mech Ageing Dev 28, 47-55.
18. Ashburner J, Friston KJ (2005) Unified segmentation. Neuroimage 26, 839-851.
19. Honjo K, van Reekum R, Verhoeff NP (2009) Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease? Alzheimers Dement 5, 348-360.
20. Renvoize EB, Awad IO, Hambling MH (1987) A seroepidemiological study of conventional infectious agents in Alzheimer's disease. Age Ageing 16, 311-314.
21. Ounanian A, Guilbert B, Renversez JC, Seigneurin JM, Avrameas S (1990) Antibodies to viral antigens, xenoantigens, and autoantigens in Alzheimer's disease. J Clin Lab Anal 4, 367-375.
22. Carvey PM, Hendey B, Monahan AJ (2009) The blood-brain barrier in neurodegenerative disease:Arhetorical perspective. J Neurochem 111, 291-314.
23. de Vries HE, Kooij G, Frenkel D, Georgopoulos S, Monsonego A, Janigro D (2012) Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: Implications for clinical disease. Epilepsia 53(Suppl 6), 45-52.
24. Burgmans S, van de Haar HJ, Verhey FR, Backes WH (2013) Amyloid-beta interacts with blood-brain barrier function in dementia: A systematic review. J Alzheimers Dis 35, 859-873.
25. Pelegri C, Canudas AM, del Valle J, Casadesus G, Smith MA, Camins A, Pallas M, Vilaplana J (2007) Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mech Ageing Dev 128, 522-528.
26. Campbell SJ, Carare-Nnadi RO, Losey PH, Anthony DC (2007) Loss of the atypical inflammatory response in juvenile and aged rats. Neuropathol Appl Neurobiol 33, 108-120.
27. Banks WA, Farr SA, Morley JE (2000) Permeability of the blood-brain barrier to albumin and insulin in the young and aged SAMP8 mouse. J Gerontol A Biol Sci Med Sci 55, B601- B606.
28. Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Jack CR Jr, Josephs KA (2012) Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: A case-control study. Lancet Neurol 11, 868-877.
29. Qiu C, De Ronchi D, Fratiglioni L (2007) The epidemiology of the dementias: An update. Curr Opin Psychiatry 20, 380-385.
30. Serra L, Cercignani M, Petrosini L, Basile B, Perri R, Fadda L, Spanò B, Marra C, Giubilei F, Carlesimo GA, Caltagirone C, Bozzali M (2011) Neuroanatomical correlates of cognitive reserve in Alzheimer disease. Rejuvenation Res 14, 143-151.
31. Wozniak MA, Itzhaki RF (2013) Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by herpes simplex virus type 1. J Neuroimmunol 257, 7-12.