Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease

Neuropharmacology

Volumn 79, Issue , 2014, Pages 212-221

  Chiu, Wei Hua ^a   Carlsson, Thomas ^a,d   Depboylu, Candan ^a   Höglinger, Günter U ^a,b,c   Oertel, Wolfgang H ^a   Ries, Vincent ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

6 Hydroxydopamine; Adult neurogenesis; Dopamine; Keywords; l Dopa; Neural progenitor cell; Olfactory bulb; Parkinson's disease; Selegiline

Indexed keywords

BENSERAZIDE PLUS LEVODOPA; LEVODOPA; OXIDOPAMINE; SELEGILINE; ANTIPARKINSON AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; MONOAMINE OXIDASE INHIBITOR; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROMODULATION; NONHUMAN; OLFACTORY BULB; PARKINSON DISEASE; PRIORITY JOURNAL; PROGENY; SUBVENTRICULAR ZONE; ANIMAL; C57BL MOUSE; CELL COUNT; DRUG EFFECTS; HIPPOCAMPUS; NERVOUS SYSTEM DEVELOPMENT; PARKINSONIAN DISORDERS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIPARKINSON AGENTS; CELL COUNT; CELL SURVIVAL; DOPAMINE AGENTS; DOPAMINERGIC NEURONS; HIPPOCAMPUS; LEVODOPA; MALE; MICE; MICE, INBRED C57BL; MONOAMINE OXIDASE INHIBITORS; NEURAL STEM CELLS; NEUROGENESIS; NEUROPROTECTIVE AGENTS; OLFACTORY BULB; OXIDOPAMINE; PARKINSONIAN DISORDERS; SELEGILINE;

EID: 84890532536     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.014     Document Type: Article

References (58)

1. J. Altman Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb J. Comp. Neurol. 137 1969 433 457
2. S. Ares-Santos, N. Granado, I. Oliva, E. O'Shea, E.D. Martin, M.I. Colado, and R. Moratalla Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine Neurobiol. Dis. 45 2012 810 820
3. S.A. Baker, K.A. Baker, and T. Hagg Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone Eur. J. Neurosci. 20 2004 575 579
4. A. Bedard, and A. Parent Evidence of newly generated neurons in the human olfactory bulb Brain Res. Dev. Brain Res. 151 2004 159 168
5. S. Belzunegui, W. San Sebastián, P. Garrido-Gil, A. Izal-Azcárate, M. Vázquez-Claverie, B. López, I. Marcilla, J.L. Lanciego, and M.-R. Luquin The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP Synapse 61 2007 1006 1012
6. H. Bernheimer, W. Birkmayer, O. Hornykiewicz, K. Jellinger, and F. Seitelberger Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations J. Neurol. Sci. 20 1973 415 455
7. L.B. Buck Smell and taste: the chemical senses E. Kandel, Principles of Neural Science fourth ed. 2000 McGraw-Hill Medical New York 625 636
8. A. Carleton, C. Rochefort, J. Morante-Oria, D. Desmaisons, J.D. Vincent, G. Gheusi, and P.-M. Lledo Making scents of olfactory neurogenesis J. Physiol. Paris 96 2002 115 122
9. T. Carlsson, F.R. Schindler, M. Höllerhage, C. Depboylu, O. Arias-Carrión, S. Schnurrbusch, T.W. Rösler, W. Wozny, G.P. Schwall, K. Groebe, W.H. Oertel, P. Brundin, A. Schrattenholz, and G.U. Höglinger Systemic administration of Neuregulin-1ß1 protects dopaminergic neurons in a mouse model of Parkinson's disease J. Neurochem. 117 2011 1066 1074
10. M.A. Curtis, M. Kam, U. Nannmark, M.F. Anderson, M.Z. Axell, C. Wikkelso, S. Holtas, W.M. van Roon-Mom, T. Bjork-Eriksson, C. Nordborg, J. Frisen, M. Dragunow, R.L. Faull, and P.S. Eriksson Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension Science 315 2007 1243 1249
11. R.L. Doty Olfaction in Parkinson's disease and related disorders Neurobiol. Dis. 46 2012 527 552
12. R.L. Doty, M.B. Stern, C. Pfeiffer, S.M. Gollomp, and H.I. Hurtig Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease J. Neurol. Neurosurg. Psychiatry 55 1992 138 142
13. S. Fahn How do you treat motor complications in Parkinson's disease: medicine, surgery, or both? Ann. Neurol. 64 Suppl. 2 2008 S56 S64
14. H.H. Fernandez, and J.J. Chen Monamine oxidase inhibitors: current and emerging agents for Parkinson disease Clin. Neuropharmacol. 30 2007 150 168
15. F.H. Gage Mammalian neural stem cells Science 287 2000 1433 1438
16. G.U. Höglinger, P. Rizk, M.P. Muriel, C. Duyckaerts, W.H. Oertel, I. Caille, and E.C. Hirsch Dopamine depletion impairs precursor cell proliferation in Parkinson disease Nat. Neurosci. 7 2004 726 735
17. A.Y. Hsia, J.D. Vincent, and P.M. Lledo Dopamine depresses synaptic inputs into the olfactory bulb J. Neurophysiol. 82 1999 1082 1085
18. E. Huisman, H.B.M. Uylings, and P.V. Hoogland A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease Mov. Disord. 19 2004 687 692
19. E. Huisman, H.B.M. Uylings, and P.V. Hoogland Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients Mov. Disord. 23 2008 1407 1413
20. I. Imayoshi, M. Sakamoto, T. Ohtsuka, K. Takao, T. Miyakawa, M. Yamaguchi, K. Mori, T. Ikeda, S. Itohara, and R. Kageyama Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain Nat. Neurosci. 11 2008 1153 1161
21. M. Jaskelioff, F.L. Muller, J.-H. Paik, E. Thomas, S. Jiang, A.C. Adams, E. Sahin, M. Kost-Alimova, A. Protopopov, J. Cadiñanos, J.W. Horner, E. Maratos-Flier, and R.A. Depinho Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice Nature 469 2011 102 106
22. H.G. Kuhn, M. Biebl, D. Wilhelm, M. Li, R.M. Friedlander, and J. Winkler Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis Eur. J. Neurosci. 22 2005 1907 1915
23. F. Lazarini, and P.M. Lledo Is adult neurogenesis essential for olfaction? Trends Neurosci. 34 2011 20 30
24. F. Lazarini, M.-A. Mouthon, G. Gheusi, F. de Chaumont, J.-C. Olivo-Marin, S. Lamarque, D.N. Abrous, F.D. Boussin, and P.-M. Lledo Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice PLoS One 4 2009 e7017
25. F. Lelan, C. Boyer, R. Thinard, S. Rémy, C. Usal, L. Tesson, I. Anegon, I. Neveu, P. Damier, P. Naveilhan, and L. Lescaudron Effects of human alpha-synuclein A53T-A30P mutations on SVZ and local olfactory bulb cell proliferation in a transgenic rat model of Parkinson disease Parkinsons Dis. 2011 2011 987084
26. Z. Liu, and L.J. Martin Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human J. Comp. Neurol. 459 2003 368 391
27. P.-M. Lledo, M. Alonso, and M.S. Grubb Adult neurogenesis and functional plasticity in neuronal circuits Nat. Rev. Neurosci. 7 2006 179 193
28. S.E. Lo, and S. Jain Patient page. Slowing down a "slow" movement disorder: selegiline's benefit in treating Parkinson disease Neurology 66 2006 E28 E29
29. C. Lois, and A. Alvarez-Buylla Long-distance neuronal migration in the adult mammalian brain Science 264 1994 1145 1148
30. K. Magyar (-)-Deprenyl, a selective MAO-b inhibitor, with apoptotic and anti-apoptotic properties NeuroToxicology 25 2004 233 242
31. G.L. Ming, and H. Song Adult neurogenesis in the mammalian brain: significant answers and significant questions Neuron 70 2011 687 702
32. A. Mouret, G. Lepousez, J. Gras, M.-M. Gabellec, and P.-M. Lledo Turnover of newborn olfactory bulb neurons optimizes olfaction J. Neurosci. 29 2009 12302 12314
33. I.-C. Mundiñano, M.-C. Caballero, C. Ordóñez, M. Hernandez, C. DiCaudo, I. Marcilla, M.-E. Erro, M.-T. Tuñon, and M.-R. Luquin Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders Acta Neuropathol. 122 2011 61 74
34. A. Nissant, and M. Pallotto Integration and maturation of newborn neurons in the adult olfactory bulb-from synapses to function Eur. J. Neurosci. 33 2011 1069 1077
35. G.C. O'Keeffe, R.A. Barker, and M.A. Caldwell Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain Cell Cycle 8 2009 2888 2894
36. G.C. O'Keeffe, P. Tyers, D. Aarsland, J.W. Dalley, R.A. Barker, and M.A. Caldwell Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF Proc. Natl. Acad. Sci. U.S.A. 106 2009 8754 8759
37. S.S. O'Sullivan, M. Johnson, D.R. Williams, T. Revesz, J.L. Holton, A.J. Lees, and E.K. Perry The effect of drug treatment on neurogenesis in Parkinson's disease Mov. Disord. 26 2011 45 50
38. J.A. Obeso, C.W. Olanow, and J.G. Nutt Levodopa motor complications in Parkinson's disease Trends Neurosci. 23 2000 S2 S7
39. S. Pålhagen, E. Heinonen, J. Hägglund, T. Kaugesaar, O. Mäki-Ikola, R. Palm, and Swedish Parkinson Study, G. Selegiline slows the progression of the symptoms of Parkinson disease Neurology 66 2006 1200 1206
40. S. Pålhagen, E.H. Heinonen, J. Hagglund, T. Kaugesaar, H. Kontants, O. Maki-Ikola, R. Palm, and J. Turunen Selegiline delays the onset of disability in de novo parkinsonian patients. Swedish Parkinson Study Group Neurology 51 1998 520 525
41. S. Parrish-Aungst, M.T. Shipley, F. Erdelyi, G. Szabo, and A.C. Puche Quantitative analysis of neuronal diversity in the mouse olfactory bulb J. Comp. Neurol. 501 2007 825 836
42. N.P. Quinn, M.N. Rossor, and C.D. Marsden Olfactory threshold in Parkinson's disease J. Neurol. Neurosurg. Psychiatry 50 1987 88 89
43. V. Ries, C. Henchcliffe, T. Kareva, M. Rzhetskaya, R. Bland, M.J. During, N. Kholodilov, and R.E. Burke Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease Proc. Natl. Acad. Sci. U.S.A. 103 2006 18757 18762
44. J. Roth, T. Radil, E. Ruzicka, R. Jech, and J. Tichy Apomorphine does not influence olfactory thresholds in Parkinson's disease Funct. Neurol. 13 1998 99 103
45. M. Sakamoto, I. Imayoshi, T. Ohtsuka, M. Yamaguchi, K. Mori, and R. Kageyama Continuous neurogenesis in the adult forebrain is required for innate olfactory responses Proc. Natl. Acad. Sci. U.S.A. 108 2011 8479 8484
46. N. Sanai, A.D. Tramontin, A. Quinones-Hinojosa, N.M. Barbaro, N. Gupta, S. Kunwar, M.T. Lawton, M.W. McDermott, A.T. Parsa, J. Manuel-Garcia Verdugo, M.S. Berger, and A. Alvarez-Buylla Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration Nature 427 2004 740 744
47. Y. Sui, M.K. Horne, and D. Stanic Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons PLoS One 7 2012 e31549
48. B. Szende, G. Bokonyi, J. Bocsi, G. Keri, F. Timar, and K. Magyar Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites J. Neural Transm. 108 2001 25 33
49. The Parkinson Study Group Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group N. Engl. J. Med. 328 1993 176 183
50. C. Tian, L.C. Murrin, and J.C. Zheng Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells PLoS One 4 2009 e5546
51. S.A. Van den Berge, M.E. van Strien, J.A. Korecka, A.A. Dijkstra, J.A. Sluijs, L. Kooijman, R. Eggers, L. De Filippis, A.L. Vescovi, J. Verhaagen, W.D. van de Berg, and E.M. Hol The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain Brain 134 2011 3249 3263
52. J.M. Van Kampen, T. Hagg, and H.A. Robertson Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation Eur. J. Neurosci. 19 2004 2377 2387
53. B. Winner, C.M. Cooper-Kuhn, R. Aigner, J. Winkler, and H.G. Kuhn Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb Eur. J. Neurosci. 16 2002 1681 1689
54. B. Winner, S. Couillard-Despres, M. Geyer, R. Aigner, U. Bogdahn, L. Aigner, H.G. Kuhn, and J. Winkler Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration J. Neuropathol. Exp. Neurol. 67 2008 105 116
55. B. Winner, P. Desplats, C. Hagl, J. Klucken, R. Aigner, S. Ploetz, J. Laemke, A. Karl, L. Aigner, E. Masliah, E. Buerger, and J. Winkler Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model Exp. Neurol. 219 2009 543 552
56. B. Winner, M. Geyer, S. Couillard-Despres, R. Aigner, U. Bogdahn, L. Aigner, G. Kuhn, and J. Winkler Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb Exp. Neurol. 197 2006 113 121
57. M. Yamada, M. Onodera, Y. Mizuno, and H. Mochizuki Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice Neuroscience 124 2004 173 181
58. S. Yasar, Z. Justinova, S.-H. Lee, R. Stefanski, S.R. Goldberg, and G. Tanda Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl] J. Pharmacol. Exp. Ther. 317 2006 387 394