The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP

Synapse

Volumn 61, Issue 12, 2007, Pages 1006-1012

  Belzunegui, Silvia ^a   San Sebastián, Waldy ^a   Garrido Gil, Pablo ^a   Izal Azcárate, Amaya ^a   Vázquez Claverie, Marianne ^a   López, Berta ^a   Marcilla, Irene ^a   Lanciego, José Luis ^a   Luquin, Maria Rosario ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Dopaminergic cells; Monkey; MPTP; Olfactory bulb; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HYPOSMIA; IMMUNOHISTOCHEMISTRY; MACACA; MALE; NONHUMAN; OLFACTORY BULB; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CELL COUNT; DOPAMINE; DOPAMINE AGENTS; DRUG ADMINISTRATION SCHEDULE; MACACA FASCICULARIS; MALE; NERVE TISSUE PROTEINS; NEURONS; OLFACTORY BULB; TYROSINE 3-MONOOXYGENASE;

EID: 37249048102     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20451     Document Type: Article

References (29)

1. Baker SA, Baker KA, Hagg T. 2004. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur J Neurosci 20:575-579.
2. Bedard A, Parent A. 2004. Evidence of newly generated neurons in the human olfactory bulb. Brain Res Dev Brain Res 151:159-168.
3. Berendse HW, Booij J, Francot CM, Bergmans PL, Hijman R, Stoof JC, Wolters EC. 2001. Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 50:34-41.
4. Betarbet R, Turner R, Chockkan V, DeLong MR, Allers KA, Walters J, Levey AI, Greenamyre JT. 1997. Dopaminergic neurons intrinsic to the primate striatum. J Neurosci 17:6761-6768.
5. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. 2004. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 318:121-134.
6. Doty RL, Deems DA, Stellar S. 1988. Olfactory dysfunction in parkinsonism: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38:1237-1244.
7. Doty RL, Singh A, Tetrud J, Langston JW. 1992. Lack of major olfactory dysfunction in MPTP-induced parkinsonism. Ann Neurol 32:97-100.
8. Forno LS. 1996. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 55:259-272.
9. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, José Luis Lanciego, María Rosario Luquin. 1988. The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857-881.
10. Hawkes CH, Shephard BC, Daniel SE. 1997. Olfactory dysfunction in Parkinson's disease. J Neurol Neurosurg Psychiatry 62:436-446.
11. Hoglinger GU, Rizk P, Muriel MP, Duyckaerts C, Oertel WH, Caille I, Hirsch EC. 2004. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci 7:726-735.
12. Hoogland PV, Huisman E. 1999. Tyrosine hydroxylase immunoreactive structures in the aged human olfactory bulb and olfactory peduncle. J Chem Neuroanat 17:153-161.
13. Hsia AY, Vincent JD, Lledo PM. 1999. Dopamine depresses synaptic inputs into the olfactory bulb. J Neurophysiol 82:1082-1085.
14. Huisman E, Uylings HB, Hoogland PV. 2004. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Mov Disord 19:687-692.
15. Huot P, Parent A. 2007. Dopaminergic neurons intrinsic to the striatum. J Neurochem 101:1441-1447.
16. Huot P, Levesque M, Parent A. 2007. The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea. Brain 130:222-232.
17. Khan NL, Katzenschlager R, Watt H, Bhatia KP, Wood NW, Quinn N, Lees AJ. 2004. Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease. Neurology 62:1224-1226.
18. Luquin MR, Laguna J, Herrero MT, Obeso JA. 1993. Behavioral tolerance to repeated apomorphine administration in parkinsonian monkeys. J Neurol Sci 114:40-44.
19. Luskin MB. 1993. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11:173-189.
20. Miwa T, Watanabe A, Mitsumoto Y, Furukawa M, Fukushima N, Moriizumi T. 2004. Olfactory impairment and Parkinson's disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Acta Otolaryngol Suppl 553:80-84.
21. Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, Deglon N, Hantraye P, Aebischer P, Kordower JH. 2002. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci 22:4942-4954.
22. Porritt MJ, Batchelor PE, Hughes AJ, Kalnins R, Donnan GA, Howells DW. 2000. New dopaminergic neurons in Parkinson's disease striatum. Lancet 356:44-45.
23. Revay R, Vaughan R, Grant S, Kuhar MJ. 1996. Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of the rat brain. Synapse 22:93-99.
24. San Sebastian W, Guillen J, Manrique M, Belzunegui S, Ciordia E, Izal-Azcarate A, Garrido-Gil P, Vazquez-Claverie M, Luquin MR. 2007. Modification of the number and phenotype of striatal dopaminergic cells by carotid body graft. Brain 130:1306-1316.
25. Smith RL, Baker H, Kolstad K, Spencer DD, Greer CA. 1991. Localization of tyrosine hydroxylase and olfactory marker protein immunoreactivities in the human and macaque olfactory bulb. Brain Res 548:140-148.
26. Tande D, Hoglinger G, Debeir T, Freundlieb N, Hirsch EC, Francois C. 2006. New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis. Brain 129:1194-1200.
27. Tashiro Y, Kaneko T, Nagatsu I, Kikuchi H, Mizuno N. 1990. Increase of tyrosine hydroxylase-like immunoreactive neurons in the nucleus accumbens and the olfactory bulb in the rat with the lesion in the ventral tegmental area of the midbrain. Brain Res 531:159-166.
28. Van Kampen JM, Hagg T, Robertson HA. 2004. Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D receptor stimulation. Eur J Neurosci 19:2377-2387.
29. Winner B, Geyer M, Couillard-Despres S, Aigner R, Bogdahn U, Aigner L, Kuhn G, Winkler J. 2006. Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb. Exp Neurol 197:113-121.