Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC

Molecular Cancer Therapeutics

Volumn 12, Issue 12, 2013, Pages 2792-2803

  Dinnen, Richard D ^a   Mao, Yuehua ^a   Qiu, Wanglong ^b   Cassai, Nicholas ^c   Slavkovich, Vesna N ^b   Nichols, Gwen ^a   Su, Gloria H ^b   Brandt Rauf, Paul ^d   Fine, Robert L ^a  

^a Pancreas Center at Columbia ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ARSENIC TRIOXIDE; ASCORBIC ACID; DISULFIRAM; PACLITAXEL; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; SUPEROXIDE DISMUTASE; VOLTAGE DEPENDENT ANION CHANNEL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APONECROSIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NECROSIS; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR VOLUME; XENOGRAFT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; ASCORBIC ACID; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROGRAFTS; HUMANS; MALE; MICE; NECROSIS; OXIDES; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; TUMOR STEM CELL ASSAY; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 84890531353     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0234     Document Type: Article

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