Arsenic trioxide and ascorbic acid: Synergy with potential implications for the treatment of acute myeloid leukaemia?

British Journal of Haematology

Volumn 112, Issue 3, 2001, Pages 783-786

  Bachleitner Hofmann, T ^a   Gisslinger, B ^a   Grumbeck, E ^a   Gisslinger, H ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Acute myeloid leukaemia; Apoptosis; Arsenic trioxide; Ascorbic acid; Synergistic effect

Indexed keywords

ARSENIC TRIOXIDE; ASCORBIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MIXTURE; DRUG POTENTIATION; DRUG SCREENING; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; ARSENICALS; ASCORBIC ACID; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HUMANS; IN SITU NICK-END LABELING; LEUKEMIA, MYELOID; MIDDLE AGED; OXIDES; TUMOR CELLS, CULTURED;

EID: 0035107590     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02608.x     Document Type: Article

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4. 3 exerts dose-dependent dual effects on APL cells
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10. Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent
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12. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species