Alternative two-step matrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency

Journal of Mass Spectrometry

Volumn 48, Issue 12, 2013, Pages 1285-1290

  Shimma, Shuichi ^a,b   Takashima, Yuki ^b,c   Hashimoto, Jun ^d   Yonemori, Kan ^d   Tamura, Kenji ^d   Hamada, Akinobu ^a,b,c  

^a NATIONAL CANCER CENTER   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

drug; imaging mass spectrometry; improvement ionization efficiency; matrix application; tissue shrinkage

Indexed keywords

APPLICATION PROCESS; APPLICATION PROTOCOLS; BIOLOGICAL COMPOUNDS; DRUG; IMAGING MASS SPECTROMETRY; IONIZATION EFFICIENCY; MATRIX ASSISTED LASER DESORPTION/IONIZATION; NON-UNIFORM CRYSTALS;

EFFICIENCY; IMAGING TECHNIQUES; IONIZATION; SECONDARY ION MASS SPECTROMETRY; SHRINKAGE; SURFACES;

TISSUE;

OLAPARIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; EXTRACTION; FEMALE; IONIZATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; REPRODUCIBILITY; SIGNAL NOISE RATIO; SURFACE PROPERTY; TISSUE INJURY; TISSUE SHRINKAGE; TUMOR XENOGRAFT; VACUUM;

DRUG; IMAGING MASS SPECTROMETRY; IMPROVEMENT IONIZATION EFFICIENCY; MATRIX APPLICATION; TISSUE SHRINKAGE;

ANIMALS; ARTIFACTS; CELL LINE, TUMOR; FEMALE; HISTOCYTOCHEMISTRY; HUMANS; LIVER; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; ORGANIC CHEMICALS; PHTHALAZINES; PIPERAZINES;

EID: 84890524084     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3288     Document Type: Article

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