Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7 receptor

Pharmaceutical Biology

Volumn 52, Issue 1, 2014, Pages 51-57

  Zhu, Shuyan ^a   Wang, Yuxiang ^a   Wang, Xinyu ^a   Li, Junying ^a   Hu, Fen ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

ATP; BBG; Cytosolic Ca2+ concentration ( Ca2+ c); IL 1 ; LPS; ROS

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; EMODIN; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; INHIBITION KINETICS; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EMODIN; INFLAMMATION; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; PHAGOCYTOSIS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2X7; RHEUM;

EID: 84890521010     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.810648     Document Type: Article

References (30)

1. Aga M, Watters JJ, Pfeiffer AZ. (2004). Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kB signaling pathways in murine RAW 264.7 macrophages. Am J Physiol Cell Physiol 286:C923-30
2. Budagian V, Bulanova E, Brovko L, et al. (2003). Signalling through P2X7 receptor in human T cells involved p65lck MAP kinases and transcription facrtors AP-1 and NF-iB. J Biol Chem 278:1549-60
3. Bulanova E, Budagian V, Orinska Z, et al. (2005). Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells. J Immunol 174:3880-90
4. Coutinho-Silva R, Ojcius DM, Górecki DC, et al. (2005). Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem Pharmacol 69:641-55
5. Coutinho-Silva R, Persechini PM, Bisaggio RD, et al. (1999). P2Z/P2X7 receptor-dependent apoptosis of dendritic cells. Am J Physiol Cell Physiol 276:C1139-47
6. Ferrari D, Pizzirani C, Adinolfi E, et al. (2006). The P2X7 receptor: A key player in IL-1 processing and release. J Immunol 176:3877-83
7. Fontanils U, Seil M, Pochet S, et al. (2010). Stimulation by P2X7 receptors of calcium-dependent production of reactive oxygen species (ROS) in rat submandibular glands. Biochim Biophys Acta 1800: 1183-91
8. Fang KM, Yang CS, Sun HS, Tzeng SF. (2009). Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X7 receptor action. J Neurochem 111:1225-37
9. Gu BJ, Saunders MB, Jursik C, Wiley SJ. (2010). The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP. Blood 115:1621-31
10. Huang HC, Chu SH, Chao PD. (1991). Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties. Eur J Pharmacol 198:211-13
11. Huang HC, Chang JH, Tung SF, et al. (1992). Immunosuppressive effect of emodin, a free radical generator. Eur J Pharmacol 18: 359-64
12. Huang Q, Shen HM, Ong CN. (2004). Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68:361-71
13. Hu F, Yang S, Zhao D, et al. (2012). Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-kB translocation and ROS production in synoviocytes. Biochem Biophys Res Commun 424:196-200
14. Jiang LH, Mackenzie AB, North RA, Surprenant A. (2000). Brilliant blue G selectively blocks ATP-gated rat P2X7 receptors. Mol Pharmacol 58:82-8
15. Kahlenberg JM, Dubyak RG. (2004). Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol 286:1100-8
16. Kaneshiro T, Morioka T, Inamine M, et al. (2006). Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur J Pharmacol 553:46-53
17. Khakh BS, North RA. (2006). P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527-32
18. Liu LJ, Zou J, Liu X, et al. (2010). Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor. Eur J Pharmacol 640:15-19
19. Marques-da-Silva C, Burnstock G, Ojciusc DM, Coutinho-Silva R. (2011). Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages. Immunobiol 216:1-11
20. Moore FS, MacKenzie BA. (2009). NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxinprimed macrophages. J Immunol 183:3302-8
21. Man Y, Wang YX, Zhu SY, et al. (2012). Indirubin inhibits ATP-induced phagocytosis attenuation, ROS production and cell death of macrophages. Acta Pharmaceut Sin 47:45-50
22. Pfeiffer AZ, Guerra NA, Hill ML, et al. (2007). Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med 42:1506-16
23. Ralevic V, Burnstock G. (1998). Receptors for purines and pyrimidines. Pharmacol Rev 50:413-92
24. Surprenant A, Rassendren F, Kawashima E, et al. (1996). The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272:735-8
25. Sanz MJ, Virgilio DF. (2000). Kinetics and mechanism of ATPdependent IL-1b release from microglial cells. Immunology 164: 4893-8
26. Tsai T, Chen C. (1992). Ultraviolet spectrum identification of emodin in rabbit plasma by HPLC and its pharmacokinetics application. Asia Pac J Pharm 7:53-6
27. Tang T, Yin LW, Yang J, Shan G. (2007). Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol 567:177-85
28. White N, Burnstock G. (2006). P2 receptors and cancer. Trends Pharmacol Sci 27:211-17
29. Zhang L, Hung MC. (1996). Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. Oncogene 12:571-6
30. Zhou XY, Yang WX, Li JY. (2006). Ca2+- and protein kinase C-dependent signaling pathway for nuclear factor-kB activation, inducible nitric-oxide synthase expression, and tumor necrosis factoralpha production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem 281:31337-47