Thyroid status and functional and cognitive status at baseline and survival after 3 years of follow-up: The OCTABAIX study

European Journal of Endocrinology

Volumn 170, Issue 1, 2014, Pages 69-75

  Formiga, Francesc ^a   Ferrer, Assumpta ^b   Padros, Gloria ^c   Contra, Anna ^a   Corbella, Xavier ^a,d   Pujol, Ramon ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b Primary Healthcare Centre 'El Plà' CAP I Sant Feliu de Llobregat   (Spain)

^c L'Hospitalet de Llobregat   (Spain)

^d UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE;

AGED; ARTICLE; CAUSE OF DEATH; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; EUTHYROIDISM; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; HUMAN; MALE; MENTAL PERFORMANCE; MINI MENTAL STATE EXAMINATION; PREDICTION; PRESCRIPTION; PRIORITY JOURNAL; QUALITY OF LIFE; SUBCLINICAL HYPERTHYROIDISM; SUBCLINICAL HYPOTHYROIDISM; SURVIVAL RATE; SURVIVAL TIME; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; VERY ELDERLY; VISUAL ANALOG SCALE;

AGED, 80 AND OVER; AGING; COHORT STUDIES; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; GERIATRIC ASSESSMENT; HUMANS; HYPERTHYROIDISM; HYPOTHYROIDISM; MALE; MILD COGNITIVE IMPAIRMENT; MORTALITY; NUTRITION ASSESSMENT; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; SPAIN; SURVIVAL ANALYSIS; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 84890504144     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0722     Document Type: Article

References (31)

1. Vitale G, Salvioli S & Franceschi C. Oxidative stress and the ageing endocrine system. Nature Reviews. Endocrinology 2013 9 228-240. (doi:10.1038/nrendo.2013.29)
2. Surks MI & Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. Journal of Clinical Endocrinology and Metabolism 2007 92 4575-4582. (doi:10.1210/jc.2007-1499)
3. Ceresini G, Ceda GP, Lauretani F, Maggio M, Usberti E, Marina M, Bandinelli S, Guralnik JM, Valenti G & Ferrucci L. Thyroid status and 6-year mortality in elderly people living in a mildly iodine-deficient area: the aging in the Chianti area study. Journal of the American Geriatrics Society 2013 61 868-874. (doi:10.1111/jgs.12267)
4. Vitale G, Fatti LM, Prolo S, Girola A, Caraglia M, Marra M, Abbruzzese A, Gerli G & Mari D. Screening for hypothyroidism in older hospitalized patients with anemia: a new insight into an old disease. Journal of the American Geriatrics Society 2010 58 1825-1827. (doi:10.1111/j.1532-5415.2010.03040.x)
5. Aghini-Lombardi F, Antonangeli L, Martino E, Vitti P, Maccherini D, Leoli F, Rago T, Grasso L, Valeriano R, Balestrieri A et al. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey. Journal of Clinical Endocrinology and Metabolism 1999 84 561-566. (doi:10.1210/jc.84.2.561)
6. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, Chezzi C, Valcavi R, Bandinelli S, Guralnik JM et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti Study. Journal of the American Geriatrics Society 2009 57 89-93. (doi:10.1111/j.1532-5415.2008.02080.x)
7. Roberts LM, Pattison H, Roalfe A, Franklyn J, Wilson S, Hobbs FD & Parle JV. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Annals of Internal Medicine 2006 145 573-581. (doi:10.7326/0003-4819-145-8-200610170-00006)
8. Simonsick EM, Newman AB, Ferrucci L, Satterfield S, Harris TB, Rodondi N, Bauer DC & Health ABC Study. Subclinical hypothyroidism and functional mobility in older adults. Archives of Internal Medicine 2009 169 2011-2017. (doi:10.1001/archinternmed.2009.392)
9. de Jongh RT, Lips P, van Schoor NM, Rijs KJ, Deeg DJ, Comijs HC, Kramer MH, Vandenbroucke JP & Dekkers OM. Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals. European Journal of Endocrinology 2011 165 545-554. (doi:10.1530/EJE-11-0430)
10. Ittermann T, Haring R, Sauer S, Wallaschofski H, Dörr M, Nauck M & Völzke H. Decreased serum TSH levels are not associated with mortality in the adult northeast German population. European Journal of Endocrinology 2010 162 579-585. (doi:10.1530/EJE-09-0566)
11. Parle JV, Maisonneuve P, Sheppard MC, Boyle P & Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet 2001 358 861-865. (doi:10.1016/S0140-6736(01)06067-6)
12. McQuade C, Skugor M, Brennan DM, Hoar B, Stevenson C & Hoogwerf BJ. Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a PreCIS database study. Thyroid 2011 21 1-7. (doi:10.1089/thy.2010. 0298)
13. Formiga F & Ferrer A. Thyrotropin serum values and 3-year mortality in nonagenarians. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2010 65 1250-1251. (doi:10.1093/gerona/glq076)
14. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M & Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. Journal of the American Medical Association 2004 292 2591-2599. (doi:10.1001/jama.292.21.2591)
15. Atzmon G, Barzilai N, Hollowell JG, Surks MI & Gabriely I. Extreme longevity is associated with increased serum thyrotropin. Journal of Clinical Endocrinology and Metabolism 2009 94 1251-1254. (doi:10.1210/jc.2008-2325)
16. Rozing MP, Westendorp RG, de Craen AJ, Frölich M, Heijmans BT, Beekman M, Wijsman C, Mooijaart SP, Blauw GJ, Slagboom PE et al. Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2010 65 365-368. (doi:10.1093/gerona/glp200)
17. Ferrer A, Badia T, Formiga F, Gild A, Padróse G, Sarróf M, Almedag J & Pujolb R. Ensayo aleatorizado de prevención de caídas y malnutrición en personas de 85 años en la comunidad. Estudio OCTABAIX. Revista Española de Geriatría y Gerontología 2010 45 79-85. (doi:10.1016/j.regg.2009.10.013)
18. Formiga F, Ferrer A, Chivite D, Montero A, Sanz H & Pujol R. Utility of geriatric assessment to predict mortality in the oldest old. The Octabaix study: three-year follow-up. Rejuvenation Research 2013 16 279-284. (doi:10.1089/rej.2013.1422)
19. Mahoney FI & Barthel DW. Functional evaluation: the Barthel index. A simple index of independence useful in scoring improvement in the rehabilitation of the chronically ill. Maryland State Medical Journal 1965 14 61-65.
20. Lawton MP & Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969 9 179-186. (doi:10.1093/geront/9.3-Part-1.179)
21. Lobo A, Saz P, Marcos G, Día JL, De la Cámara C, Ventura T, Morales Asín F, Fernando Pascual L, Montañés JA & Aznar S. Revalidación y normalización del Mini-Examen Cognoscitivo (primera versión en castellano del Mini-mental Status Examination) en la población general geriátrica. Medicina Clínica 1999 112 767-774.
22. Guigoz Y, Vellas B & Garry PJ. Assessing the nutritional status of the elderly: the Mini Nutritional Assessment as part of the geriatric evaluation. Nutrition Reviews 1996 54 (Suppl) 59-65.
23. Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. Journal of the American Geriatrics Society 1986 34 119-126.
24. Herdman M, Badia X & Berra S. El EuroQol-5D: una alternativa sencilla para medir calidad de vida relacionada con salud en atención primaria. Atencion Primaria 2001 28 425-430. (doi:10.1016/S0212-6567(01)70406-4)
25. Charlson ME, Pompei P, Ales KL & MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. Journal of Chronic Diseases 1987 40 373-383. (doi:10.1016/0021- 9681(87)90171-8)
26. von Heideken Wågert P, Gustafson Y, Kallin K, Jensen J & Lundin-Olsson L. Falls in very old people: the population-based Umeå 85 + study in Sweden. Archives of Gerontology and Geriatrics 2009 49 390-396. (doi:10.1016/j.archger.2008.12.005)
27. Park YJ, Lee EJ, Lee YJ, Choi SH, Park JH, Lee SB, Lim S, Lee WW, Jang HC, Cho BY et al. Subclinical hypothyroidism (SCH) is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life (QoL) in elderly subjects. Archives of Gerontology and Geriatrics 2010 50 e68-e73. (doi:10.1016/j.archger.2009.05.015)
28. Waring AC, Harrison S, Samuels MH, Ensrud KE, LeBLanc ES, Hoffman AR, Orwoll E, Fink HA, Barrett-Connor E, Bauer DC et al. Thyroid function and mortality in older men: a prospective study. Journal of Clinical Endocrinology and Metabolism 2012 97 862-870. (doi:10.1210/jc.2011-2684)
29. Díez JJ & Iglesias P. Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. Journal of Clinical Endocrinology and Metabolism 2004 89 4890-4897. (doi:10.1210/jc.2003-032061)
30. Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J & Rodondi N. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Annals of Internal Medicine 2008 148 832-845. (doi:10.7326/0003-4819-148-11-200806030-00225)
31. Razvi S, Weaver JU, Vanderpump MP & Pearce SH. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. Journal of Clinical Endocrinology and Metabolism 2010 95 1734-1740. (doi:10.1210/jc.2009-1749)