Muckle-Wells treatment with anakinra

Dermatology Online Journal

Volumn 19, Issue 12, 2013, Pages 16-

  Eungdamrong, John ^a   Boyd, Kevin P ^a   Meehan, Shane A ^a   Latkowski, Jo Ann ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; ASPARAGINE; ASPARTIC ACID; METHOTREXATE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT; ARTHRALGIA; ARTHRITIS; ARTICLE; CASE REPORT; EOSINOPHIL; ERYTHEMA; FOLLOW UP; GENE; GENE MUTATION; HETEROZYGOSITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPHOCYTIC INFILTRATION; MALE; MEDICAL HISTORY; MUCKLE WELLS SYNDROME; MUTATIONAL ANALYSIS; NEUTROPHIL CHEMOTAXIS; NLRP3 GENE; PERCEPTION DEAFNESS; PHYSICAL EXAMINATION; PLASMA CELL; URTICARIA;

EID: 84890502261     PISSN: 10872108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Muckle TJ, Wells M. Urticaria, deafness and amyloidosis: a new heredo-familial syndrome. Quart J Med 1962; 31: 235
2. Hawkins PN, et al. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 2004; 50: 607
3. Hoffman HM, et al. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genet 2001; 29: 301
4. Meng G, et al. A mutation in the NLRP3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009; 30: 860
5. Agostini L, et al. NALP forms an IL-1β processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20: 319
6. Hawkins PN, Lachmann HJ. Interleukin-1 receptor antagonist in the Muckle Wells syndrome. N Engl J Med 2003; 348: 2583
7. Kuemmerle-Deschner JB, et al. Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome. Arthritis Rheum 2011; 63: 840