Metabolomics and transcriptomics demonstrate severe oxidative stress in both localized chemotherapy-treated and bystander tumors

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 3, 2014, Pages 1092-1104

  Morvan, Daniel ^a,b   Demidem, Aicha ^c  

^a UDA University   (France)

^b CENTRE JEAN PERRIN   (France)

^c INRA and University of Auvergne   (France)

Author keywords

Bystander tumor; Chemotherapy; Metabolomics; Oxidative stress; Transcriptomics

Indexed keywords

EXTRACELLULAR SUPEROXIDE DISMUTASE; FOTEMUSTINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 3; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; MELATONIN 1 RECEPTOR; PHOSPHOLIPID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2; PYRUVATE KINASE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; GENE OVEREXPRESSION; GPX3 GENE; HMOX1 GENE; IN VIVO STUDY; LIVER; MALE; MELANOMA B16; METABOLOMICS; MOUSE; MT1 GENE; NONHUMAN; OXIDATIVE STRESS; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SOD3 GENE; SOLEUS MUSCLE; TRANSCRIPTOMICS; TUMOR GROWTH;

BS; BYSTANDER; BYSTANDER TUMOR; CHEMOTHERAPY; CONTROL; CTL; I.P.; I.T.; INH; INHIBITION PHASE; INTRAPERITONEAL; INTRATUMOR; METABOLOMICS; OXIDATIVE STRESS; REC; RECOVERY PHASE; TRANSCRIPTOMICS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BYSTANDER EFFECT; CELL PROLIFERATION; MALE; MELANOMA, EXPERIMENTAL; METABOLOMICS; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; TRANSCRIPTOME;

EID: 84890485078     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.11.022     Document Type: Article

References (36)

1. J.B. Little Genomic instability and bystander effects: a historical perspective Oncogene 22 2003 6978 6987 (Pubitemid 37386665)
2. L. Huang, A.R. Snyder, and W.F. Morgan Radiation-induced genomic instability and its implications for radiation carcinogenesis Oncogene 22 2003 5848 5854 (Pubitemid 37176705)
3. H. Nagasawa, and J.B. Little Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect Radiat. Res. 152 1999 552 557 (Pubitemid 29514159)
4. I. Koturbash, J. Loree, K. Kutanzi, C. Koganow, I. Pogribny, and O. Kovalchuk In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen Int. J. Radiat. Oncol. Biol. Phys. 70 2008 554 562
5. M. Mancuso, E. Pasquali, S. Leonardi, S. Rebessi, M. Tanori, P. Giardullo, F. Borra, S. Pazzaglia, C.C. Naus, V. Di Majo, and A. Saran Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo Oncogene 30 2011 4601 4608
6. M. Mancuso, E. Pasquali, S. Leonardi, M. Tanori, S. Rebessi, V. Di Majo, S. Pazzaglia, M.P. Toni, M. Pimpinella, V. Covelli, and A. Saran Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum Proc. Natl. Acad. Sci. U. S. A. 105 2008 12445 12450
7. D.P. Kingsley An interesting case of possible abscopal effect in malignant melanoma Br. J. Radiol. 48 1975 863 866
8. P.J. Wersall, H. Blomgren, P. Pisa, I. Lax, K.M. Kalkner, and C. Svedman Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma Acta Oncol. 45 2006 493 497 (Pubitemid 43884622)
9. A. Demidem, D. Morvan, J. Papon, M. De Latour, and J.C. Madelmont Cystemustine induces redifferentiation of primary tumors and confers protection against secondary tumor growth in a melanoma murine model Cancer Res. 61 2001 2294 2300 (Pubitemid 32692062)
10. A. Demidem, D. Morvan, and J.C. Madelmont Bystander effects are induced by CENU treatment and associated with altered protein secretory activity of treated tumor cells: a relay for chemotherapy? Int. J. Cancer 119 2006 992 1004 (Pubitemid 44116905)
11. J. Alexandre, Y. Hu, W. Lu, H. Pelicano, and P. Huang Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species Cancer Res. 67 2007 3512 3517 (Pubitemid 46762129)
12. S. Kohsaka, K. Takahashi, L. Wang, M. Tanino, T. Kimura, H. Nishihara, and S. Tanaka Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma Cancer Lett. 1 2013 68 75 10.1016/j.canlet. 2012.12.005 (Epub 2012 Dec 12) (PMID:23246370)
13. J.B. Little, H. Nagasawa, G.C. Li, and D.J. Chen Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations Radiat. Res. 159 2003 262 267 (Pubitemid 36182405)
14. R. Baskar Emerging role of radiation induced bystander effects: cell communications and carcinogenesis Genome Integr. 1 2010 13
15. J.S. Dickey, B.J. Baird, C.E. Redon, V. Avdoshina, G. Palchik, J. Wu, A. Kondratyev, W.M. Bonner, and O.A. Martin Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity Nucleic Acids Res. 40 2012 10274 10286
16. Y. Ohshima, M. Tsukimoto, H. Harada, and S. Kojima Involvement of connexin43 hemichannel in ATP release after gamma-irradiation J. Radiat. Res. 53 2012 551 557
17. L. Aymeric, L. Apetoh, F. Ghiringhelli, A. Tesniere, I. Martins, G. Kroemer, M.J. Smyth, and L. Zitvogel Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity Cancer Res. 70 2010 855 858
18. L. Senovilla, I. Vitale, I. Martins, M. Tailler, C. Pailleret, M. Michaud, L. Galluzzi, S. Adjemian, O. Kepp, M. Niso-Santano, S. Shen, G. Marino, A. Criollo, A. Boileve, B. Job, S. Ladoire, F. Ghiringhelli, A. Sistigu, T. Yamazaki, S. Rello-Varona, C. Locher, V. Poirier-Colame, M. Talbot, A. Valent, F. Berardinelli, A. Antoccia, F. Ciccosanti, G.M. Fimia, M. Piacentini, A. Fueyo, N.L. Messina, M. Li, C.J. Chan, V. Sigl, G. Pourcher, C. Ruckenstuhl, D. Carmona-Gutierrez, V. Lazar, J.M. Penninger, F. Madeo, C. Lopez-Otin, M.J. Smyth, L. Zitvogel, M. Castedo, and G. Kroemer An immunosurveillance mechanism controls cancer cell ploidy Science 337 2012 1678 1684
19. 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy Magn. Reson. Med. 63 2010 1172 1183
20. D. Morvan, and A. Demidem Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways Cancer Res. 67 2007 2150 2159 (Pubitemid 46424234)
21. 13C nuclear magnetic resonance spectroscopy Magn. Reson. Med. 55 2006 984 996
22. C.E. Redon, J.S. Dickey, A.J. Nakamura, I.G. Kareva, D. Naf, S. Nowsheen, T.B. Kryston, W.M. Bonner, A.G. Georgakilas, and O.A. Sedelnikova Tumors induce complex DNA damage in distant proliferative tissues in vivo, Proc. Natl. Acad. Sci. U. S. A. 107 42 2010 17992 17997 10.1073/pnas (Epub 2010 Sep 20) (PMID:20855610)
23. T.W. Fan, P. Yuan, A.N. Lane, R.M. Higashi, Y. Wang, A.B. Hamidi, R. Zhou, X. Guitart, G. Chen, H.K. Manji, and R. Kaddurah-Daouk Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions Metabolomics 6 2010 165 179
24. M.A. Selak, S.M. Armour, E.D. MacKenzie, H. Boulahbel, D.G. Watson, K.D. Mansfield, Y. Pan, M.C. Simon, C.B. Thompson, and E. Gottlieb Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase Cancer Cell 7 2005 77 85 (Pubitemid 40126384)
25. I. Martins, A. Tesniere, O. Kepp, M. Michaud, F. Schlemmer, L. Senovilla, C. Seror, D. Metivier, J.L. Perfettini, L. Zitvogel, and G. Kroemer Chemotherapy induces ATP release from tumor cells Cell Cycle 8 2009 3723 3728
26. L. Zitvogel, O. Kepp, L. Aymeric, Y. Ma, C. Locher, N.F. Delahaye, F. Andre, and G. Kroemer Integration of host-related signatures with cancer cell-derived predictors for the optimal management of anticancer chemotherapy Cancer Res. 70 2010 9538 9543
27. A. Ramirez de Molina, D. Gallego-Ortega, J. Sarmentero, M. Banez-Coronel, Y. Martin-Cantalejo, and J.C. Lacal Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis Cancer Res. 65 2005 5647 5653 (Pubitemid 40911165)
28. J.A. Menendez, and R. Lupu Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells Curr. Opin. Clin. Nutr. Metab. Care 9 2006 346 357 (Pubitemid 44101969)
29. 1H MRS and histological analysis NMR Biomed. 21 2008 677 685
30. A. Baracca, F. Chiaradonna, G. Sgarbi, G. Solaini, L. Alberghina, and G. Lenaz Mitochondrial complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells Biochim. Biophys. Acta 1797 2009 314 323
31. J.C. Wolfman, S.M. Planchon, J. Liao, and A. Wolfman Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria Biochim. Biophys. Acta 1763 2006 1108 1124 (Pubitemid 44479794)
32. F. Chiaradonna, D. Gaglio, M. Vanoni, and L. Alberghina Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts Biochim. Biophys. Acta 1757 2006 1338 1356 (Pubitemid 44442142)
33. S. Nugent, C.E. Mothersill, C. Seymour, B. McClean, F.M. Lyng, and J.E. Murphy Altered mitochondrial function and genome frequency post exposure to γ-radiation and bystander factors Int. J. Radiat. Biol. 86 2010 829 841
34. H. Zhou, V.N. Ivanov, Y.C. Lien, M. Davidson, and T.K. Hei Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects Cancer Res. 68 2008 2233 2240 (Pubitemid 351521796)
35. C. Trainor, K.T. Butterworth, C.K. McGarry, S.J. McMahon, J.M. O'Sullivan, A.R. Hounsell, and K.M. Prise DNA damage responses following exposure to modulated radiation fields PLoS One 7 2012 e43326
36. K.T. Butterworth, C.K. McGarry, C. Trainor, J.M. O'Sullivan, A.R. Hounsell, and K.M. Prise Out-of-field cell survival following exposure to intensity-modulated radiation fields Int. J. Radiat. Oncol. Biol. Phys. 79 2011 1516 1522