Enhanced antinociceptive efficacy of epidural compared with i.v. methadone in a rat model of thermal nociception

British Journal of Anaesthesia

Volumn 112, Issue 1, 2014, Pages 150-158

  Haroutiunian, S ^a,d   Kagan, L ^b   Yifrach Damari, I ^a   Davidson, E ^c   Ratz, Y ^a   Hoffman, A ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b RUTGERS UNIVERSITY   (United States)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

analgesia epidural; methadone; models animal; pharmacokinetics

Indexed keywords

HOT WATER; METHADONE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; AUDITORY CANAL; COMPARTMENT MODEL; CONTROLLED STUDY; CORNEA REFLEX; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; EPIDURAL ANESTHESIA; INTERMETHOD COMPARISON; INTRAVENOUS ANESTHESIA; LATENT PERIOD; MALE; MEAN RESIDENCE TIME; NOCICEPTION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REFLEX; SINGLE DRUG DOSE; SPINAL CORD; STEADY STATE; TAIL FLICK TEST; TAIL IMMERSION TEST;

EID: 84890466127     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aet234     Document Type: Article

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