Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: Results from a study in 885 patients

Journal of Dermatological Treatment

Volumn 25, Issue 1, 2014, Pages 30-33

  Saraceno, Rosita ^a   Camplone, Germana ^b   D'Agostino, Magda ^c   De Simone, Clara ^c   Di Cesare, Antonella ^d   Filosa, Giorgio ^e   Frascione, Pasquale ^f   Gabellini, Massimo ^g   Lunghi, Franco ^h   Mazzotta, Annamaria ⁱ   Peris, Ketty ^d   Scotto Di Luzio, Genoveffa ^j   Calvieri, Stefano ^k   Simonacci, Marco ^l   Chimenti, Sergio ^a  

^a TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e Medical and Surgery Emergency Unit   (Italy)

^f SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

^g BUFALINI HOSPITAL   (Italy)

^h F Spaziani Hospital   (Italy)

ⁱ S EUGENIO HOSPITAL   (Italy)

^j Azienda Ospedaliera Sant'Anna e San Sebastiano   (Italy)

^k SAPIENZA UNIVERSITY OF ROME   (Italy)

^l UO Dermatologia Ospedale di Macerata Area Vasta 3 ASUR   (Italy)

more..

Author keywords

Calcipotriol betamethasone dipropionate; Gel formulation; IGA; PGA; Scalp psoriasis; SSA; TSS; Two compound product

Indexed keywords

BETAMETHASONE DIPROPIONATE PLUS CALCIPOTRIOL; UNCLASSIFIED DRUG; XAMIOL;

ADULT; ARTICLE; BURNING SENSATION; CLINICAL EVALUATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG FORMULATION; DRUG INDUCED HEADACHE; DRUG SAFETY; ERYTHEMA; FEMALE; FOLLICULITIS; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARESTHESIA; PATIENT COMPLIANCE; PRIORITY JOURNAL; PRURITUS; PSORIASIS; RANDOMIZED CONTROLLED TRIAL; RELAPSE; REMISSION; SCALP PSORIASIS; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; BETAMETHASONE; CALCITRIOL; CHEMISTRY, PHARMACEUTICAL; DERMATOLOGIC AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; GELS; HUMANS; MALE; MIDDLE AGED; PSORIASIS; RECURRENCE; SCALP DERMATOSES; YOUNG ADULT;

EID: 84890455931     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2013.800182     Document Type: Article

References (17)

1. Schon MP, Boehncke WH. Psoriasis. N Engl J Med. 2005;352:1899- 1912.
2. Saraceno R, Ruzzetti M, Mannheimer R, Chimenti S. Regional distribution of psoriasis in Italy. J Eur Acad Dermatol Venereol. 2008;22: 324-329.
3. Farber EM, Nall L. Natural history and treatment of scalp psoriasis. Cutis. 1992;49:396-400.
4. Van de Kerkhof PC, de Hoop D, de Korte J, Kuipers MV. Scalp psoriasis, clinical presentations and therapeutic management. Dermatology. 1998;197:326-334.
5. Van de Kerkhof PC, Franssen ME. Psoriasis of the scalp. Diagnosis and management. Am J Clin Dermatol. 2001;2:159-165.
6. Ortonne J, Chimenti S, Luger T, Puig L, Reid F, Trüeb RM. Scalp psoriasis: European consensus on grading and treatment algorithm. J Eur Acad Dermatol Venereol. 2009;23:1435-1444.
7. Guenther L, Van de Kerkhof PC, Snellman E, Kragballe K, Chu AC, Tegner E, et al. Efficacy and safety of a new combination of calcipotriol and betamethasone dipropionate (once or twice daily) compared to calcipotriol (twice daily) in the treatment of psoriasis vulgaris: a randomized, double-blind, vehicle-controlled clinical trial. Br J Dermatol. 2002;147:316-323.
8. Papp KA, Guenther L, Boyden B, Larsen FG, Harvima RJ, Guilhou JJ, et al. Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis. J Am Acad Dermatol. 2003;48:48-54.
9. Saraceno R, Andreassi L, Ayala F, Bongiorno MR, Giannetti A, Lisi P, et al. Efficacy, safety and quality of life of calcipotriol/betamethasone dipropionate (Dovobet) versus calcipotriol (Daivonex) in the treatment of psoriasis vulgaris: a randomized, multicentre, clinical trial. J Dermatolog Treat. 2007;18:361-365.
10. Kragballe K, Hoffmann V, Ortonne JP, Tan J, Nordin P, Segaert S. Efficacy and safety of calcipotriol plus betamethasone dipropionate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trial. Br J Dermatol. 2009;161:159-166.
11. Luger TA, Cambazard F, Larsen FG, Bourcier M, Gupta G, Clonier F, et al. A study of the safety and efficacy of calcipotriol and betamethasone dipropionate scalp formulation in the long-term management of scalp psoriasis. Dermatology. 2008;217:321-328.
12. Jemec GB, Ganslandt C, Ortonne JP, Poulin Y, Burden AD, de Unamuno P, et al. A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trial. J Am Acad Dermatol. 2008;59:455-463.
13. van de Kerkhof PC, Hoffmann V, Anstey A, Barnes L, Bolduc C, Reich K, et al. A new scalp formulation of calcipotriol plus betamethasone dipropionate compared with each of its active ingredientsin the same vehicle for the treatment of scalp psoriasis: a randomized, double-blind, controlled trial. Br J Dermatol. 2009;160: 170-176.
14. Buckley C, Hoffmann V, Shapiro J, Saari S, Cambazard F, Milsgaard M. Calcipotriol plus betamethasone dipropionate scalp formulation is effective and well tolerated in the treatment of scalp psoriasis: a phase II study. Dermatology. 2008;217:107-113.
15. Dubertret L, Mrowietz U, Ranki A, van de Kerkhof PC, Chimenti S, Lotti T, EUROPSO Patient Survey Group. European patient perspectives on the impact of psoriasis: the EUROPSO patient membership survey. Br J Dermatol. 2006;155:729-736.
16. Mrowietz U, Macheleidt O, Eicke C. Effective treatment and improvement of quality of life in patients with scalp psoriasis by topical use of calcipotriol/betamethasone (Xamiol-gel): results. J Dtsch Dermatol Ges. 2011;9:825-831.
17. Saraceno R, Gramiccia T, Frascione P, Chimenti S. Calcipotriene/ betamethasone in the treatment of psoriasis: a review article. Expert Opin Pharmacother. 2009;10:2357-2365.