A new scalp formulation of calcipotriene plus betamethasone compared with its active ingredients and the vehicle in the treatment of scalp psoriasis: A randomized, double-blind, controlled trial

Journal of the American Academy of Dermatology

Volumn 59, Issue 3, 2008, Pages 455-463

  Jemec, Gregor B E ^a   Ganslandt, Cecilia ^b   Ortonne, Jean Paul ^c   Poulin, Yves ^d   Burden, A David ^e   de Unamuno, Pablo ^f   Berne, Berit ^g   Figueiredo, Américo ^h   Austad, Joar ⁱ  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LEO PHARMA A S   (Denmark)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^d Centre de Recherche Dermatologique du Quebec Metropolitain   (Canada)

^e WESTERN INFIRMARY   (United Kingdom)

^f HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^g UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^h CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

ⁱ Hudlegekontoret   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE DIPROPIONATE; CALCIPOTRIOL; PLACEBO;

ACNEIFORM DERMATITIS; ADULT; AGED; ALOPECIA; ANXIETY; ARTICLE; BURN; BURNING SENSATION; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTACT DERMATITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMATITIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG WITHDRAWAL; ECZEMA; ERYTHEMA; EXCORIATION; FEMALE; FOLLICULITIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; PAIN; PARESTHESIA; PEDICULOSIS; PRIORITY JOURNAL; PRURITUS; PSORIASIS; PUSTULE; RANDOMIZED CONTROLLED TRIAL; RASH; SCALP; SCORING SYSTEM; SIDE EFFECT; SKIN BURNING SENSATION; SKIN INJURY; SKIN IRRITATION; SKIN PAIN; SKIN PRURITUS; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VITILIGO;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; BETAMETHASONE; CALCITRIOL; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PSORIASIS; SCALP DERMATOSES; SEVERITY OF ILLNESS INDEX; SKIN; TREATMENT OUTCOME; VEHICLES;

EID: 48949083211     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2008.04.027     Document Type: Article

References (23)

1. Feldman S.R., and Housman T.S. Patients' vehicle preference for corticosteroid treatments of scalp psoriasis. Am J Clin Dermatol 4 (2003) 221-224
2. Farber E.M., and Nall M.L. The natural history of psoriasis in 5,600 patients. Dermatologica 148 (1974) 1-18
3. Poyner T.F., and Fell P.J. A survey of patients with plaque psoriasis who had not consulted their doctor in the past year. Br J Clin Res 6 (1995) 201-207
4. van de Kerkhof P.C.M., Steegers-Theunissen R.P.M., and Kuipers M.V. Evaluation of topical drug treatment in psoriasis. Dermatology 197 (1998) 31-36
5. Farber E.M., Bright R.D., and Nall M.L. Psoriasis. A questionnaire survey of 2,144 patients. Arch Dermatol 98 (1968) 248-259
6. van de Kerkhof P.C., and Chang A. Scarring alopecia and psoriasis. Br J Dermatol 126 (1992) 524-525
7. Shuster S. Psoriatic alopecia. Br J Dermatol 87 (1972) 73-77
8. Brandrup F., and Green A. The prevalence of psoriasis in Denmark. Acta Derm Venereol 61 (1981) 344-346
9. van de Kerkhof P.C.M., de Hoop D., de Korte J., and Kuipers M.V. Scalp psoriasis, clinical presentations and therapeutic management. Dermatology 197 (1998) 326-334
10. Green C., Ganpule M., Harris D., Kavanagh G., Kennedy C., Mallett R., et al. Comparative effects of calcipotriol (MC903) solution and placebo (vehicle of MC903) in the treatment of psoriasis of the scalp. Br J Dermatol 130 (1994) 483-487
11. Thaçi D., Daiber W., Boehncke W.H., and Kaufmann R. Calcipotriol solution for the treatment of scalp psoriasis: evaluation of efficacy, safety and acceptance in 3,396 patients. Dermatology 203 (2001) 153-156
12. Holm E.A., and Jemec G.B.E. Calcipotriol therapy beyond psoriasis. Int J Dermatol 41 (2002) 38-43
13. Barnes L., Altmeyer P., Forstrom L., and Stenstrom M.H. Long-term treatment of psoriasis with calcipotriol scalp solution and cream. Eur J Dermatol 10 (2000) 199-204
14. Kragballe K., Austad J., Barnes L., Bibby A., de la Brassinne M., Cambazard F., et al. A 52-week randomized safety study of a calcipotriol/betamethasone dipropionate two-compound product (Dovobet/Daivobet/Taclonex) in the treatment of psoriasis vulgaris. Br J Dermatol 154 (2006) 1155-1160
15. Kragballe K., and van de Kerkhof P.C. Consistency of data in six phase III clinical studies of a two-compound product containing calcipotriol and betamethasone dipropionate ointment for the treatment of psoriasis. J Eur Acad Dermatol Venereol 20 (2006) 39-44
16. Kaufmann R., Bibby A.J., Bissonnette R., Cambazard F., Chu A.C., Decroix J., et al. A new calcipotriol/betamethasone formulation is a highly effective once-daily treatment for psoriasis vulgaris. Dermatology 205 (2002) 389-393
17. van de Kerkhof P.C.M., and Franssen M.E.J. Psoriasis of the scalp: diagnoses and management. Am J Clin Dermatol 2 (2001) 159-165
18. van der Vleuten C.J.M., and van de Kerkhof P.C.M. Management of scalp psoriasis. Guidelines for corticosteroid use in combination treatment. Drugs 61 (2001) 1593-1598
19. Koo J. Vitamin D and scalp psoriasis. Cutis 70 Suppl (2002) 21-24
20. Buckley C., and Hoffmann V. Calcipotriol plus betamethasone dipropionate gel is effective and safe in the treatment of scalp psoriasis (a phase II study). J Eur Acad Dermatol Venereol 19 Suppl 2 (2005) 175
21. Papp K.A., Guenther L., Boyden B., Grønhøj Larsen F., Harvima R.J., Guilhou J.J., et al. Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis. J Am Acad Dermatol 48 (2003) 48-54
22. Douglas W.S., Poulin Y., Decroix J., Ortonne J.P., Mrowietz U., Gulliver W., et al. A new calcipotriol/betamethasone formulation with rapid onset of action was superior to monotherapy with betamethasone dipropionate or calcipotriol in psoriasis vulgaris. Acta Derm Venereol 82 (2002) 131-135
23. Jemec G.B.E., and Wulf H.C. The greasiness of moisturisers. J Soc Cosmet Chem 49 (1998) 175-181