Evaluation of circulating Transforming growth factor-beta1, Glypican-3 and Golgi protein-73 mRNAs expression as predictive markers for hepatocellular carcinoma in Egyptian patients

Molecular Biology Reports

Volumn 40, Issue 12, 2013, Pages 7069-7075

  Ibrahim, Gehan H ^a   Mahmoud, Moushira A ^a   Aly, Nagwa M ^a  

^a Suez Canal University Faculty of Medicine   (Egypt)

Author keywords

Gene expression; Glypican 3; Golgi protein 73; Hepatocellular carcinoma; Serum biomarkers; Transforming growth factor beta

Indexed keywords

ALPHA FETOPROTEIN; GLYPICAN 3; GOLGI PROTEIN 73; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER DIAGNOSIS; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE MARKER; EARLY DIAGNOSIS; EGYPTIAN; ETHNIC GROUP; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; MALE; PREDICTIVE VALUE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

HEPATITIS C VIRUS;

CARCINOMA, HEPATOCELLULAR; DEMOGRAPHY; EGYPT; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYPICANS; HEPATITIS C, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MARKERS, BIOLOGICAL;

EID: 84890426752     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2829-3     Document Type: Article

References (37)

1. Herszényi L, Tulassay Z (2010) Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci 14:249-258
2. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108
3. Bosch FX, Ribes J, Cleries R, Diaz M (2005) Epidemiology of hepatocellular carcinoma. Clin Liver Dis 9:191-211
4. El-Zayadi AR, Badran HM, Barakat EM, Attia Mel-D, Shawky S, Mohamed MK, Selim O, Saeid A (2005) Hepatocellular carcinoma in Egypt: a single center study over a decade. World J Gastroenterol 11:5193-5198
5. Ibrahim AS, Mikhail NNH, Darwish H, Heikel T, Baraka H, Khaled H, Abdel Wahed S, Abdel Latef AS (eds) (2011) Egypt National Cancer Registry: Damietta Profile 2009. Egypt National Cancer Registry, Cairo
6. Parkin DM, Bray FI, Devesa SS (2001) Cancer burden in the year 2000: the global picture. Eur J Cancer 37:S4-S66
7. Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208-1236
8. El-Serag HB (2011) Hepatocellular carcinoma. N Engl J Med 365:1118-1127
9. Stefaniuk P, Cianciara J, Wiercinska-Drapalo A (2010) Present and future possibilities for early diagnosis of hepatocellular carcinoma. World J Gastroenterol 16:418-424
10. Malaguarnera G, Giordano M, Paladina I, Berretta M, Cappellani A, Malaguarnera M (2010) Serum markers of hepatocellular carcinoma. Dig Dis Sci 55:2744-2755
11. Nam SW, Park JY, Ramasamy A, Shevade S, Islam A, Long PM, Park CK, Park SE, Kim SY, Lee SH, Park WS, Yoo NJ, Liu ET, Miller LD, Lee JY (2005) Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology 42:809-818
12. Gomaa AI, Khan SA, Leen EL, Waked I, Taylor-Robinson SD (2009) Diagnosis of hepatocellular carcinoma. World J Gastroenterol 15:1301-1314
13. Lopez JB (2005) Recent developments in the first detection of hepatocellular carcinoma. Clin Biochem Rev 26:65-79
14. Spencer WE, Christensen MJ (1999) Multiplex relative RT-PCR method for verification of differential gene expression. Biotechniques 27:1044-1052
15. Youssef MF, El-Sharkawy SL, Abbas NF, Shinnawy S, El-Hadidi E, Shahin R, Shalabi H (2010) Clinical utility of Glypican-3 in Hepatocellular carcinoma. Int J Integr Biol 10:41-47
16. Okumoto K, Hattori E, Tamura K, Kiso S, Watanabe H, Saito K, Saito T, Togashi H, Kawata S (2004) Possible contribution of circulating transforming growth factor-beta1 to immunity and prognosis in unresectable hepatocellular carcinoma. Liver Int 24:21-28
17. Dong ZZ, Yao DF, Yao M, Qiu LW, Zong L, Wu W, Wu XH, Yao DB, Meng XY (2008) Clinical impact of plasma TGF-β1 and circulating TGF-β1 mRNA in diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 7:288-295
18. Lu ZL, Luo DZ, Wen JM (2005) Expression and significance of tumor-related genes in HCC. World J Gastroenterol 11:3850-3854
19. Capurro MI, Xiang YY, Lobe C, Filmus J (2005) Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. Cancer Res 65:6245-6254
20. Kladney RD, Cui X, Bulla GA, Brunt EM, Fimmel CJ (2002) Expression of GP73, a resident golgi membrane protein, in viral and nonviral liver disease. Hepatology 35:1431-1440
21. Iftikhar R, Kladney RD, Havlioglu N, Schmitt-Gräff A, Gusmirovic I, Solomon H, Luxon BA, Bacon BR, Fimmel CJ (2004) Disease and cell-specific expression of GP73 in human liver disease. Am J Gastroenterol 99:1087-1095
22. Hu JS, Wu DW, Liang S, Miao XY (2010) GP73, a resident Golgi glycoprotein, is sensibility and specificity for hepatocellular carcinoma of diagnosis in a hepatitis B-endemic Asian population. Med Oncol 27:339-345
23. Fimmel CJ, Wright L (2009) Golgi protein 73 as a biomarker of hepatocellular cancer: development of a quantitative serum assay and expression studies in hepatic and extrahepatic malignancies. Hepatology 49:1421-1423
24. Yoon SK (2008) Recent advances in tumor markers of human hepatocellular carcinoma. Intervirology 51:34-41
25. Gu Y, Chen W, Zhao Y, Chen L, Peng T (2009) Quantitative analysis of elevated serum Golgi protein-73 expression in patients with liver diseases. Ann Clin Biochem 46:38-43
26. Riener MO, Stenner F, Liewen H, Soll C, Breitenstein S, Pestalozzi BC, Samaras P, Probst-Hensch N, Hellerbrand C, Müllhaupt B, Clavien PA, Bahra M, Neuhaus P, Wild P, Fritzsche F, Moch H, Jochum W, Kristiansen G (2009) Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas. Hepatology 49:1602-1609
27. Zhou Y, Yin X, Ying J, Zhang B (2012) Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis. BMC Cancer 12:17
28. Lo YM, Chiu RW (2004) The biology and diagnostic applications of plasma RNA. Ann N Y Acad Sci 1022:135-139
29. Wang Y, Shen Z, Zhu Z, Han R, Huai M (2011) Clinical values of AFP, GPC3 mRNA in peripheral blood for prediction of hepatocellular carcinoma recurrence following OLT: AFP, GPC3 mRNA for prediction of HCC. Hepat Mon 11:195-199
30. Yan D, He Q, Chen Y, Wang L, Zhang X (2011) Detection of α-fetoprotein and glypican-3 mRNAs in the peripheral blood of hepatocellular carcinoma patients by using multiple FQ-RT-PCR. J Clin Lab Anal 25:113-117
31. Abdul-Al HM, Makhlouf HR, Wang G, Goodman ZD (2008) Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma. Hum Pathol 39:209-212
32. Lehman EM, Wilson ML (2009) Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and meta-analysis. Int J Cancer 124:690-697
33. Bachert C, Fimmel C, Linstedt AD (2007) Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinoma. Traffic 8:1415-1423
34. Chou HT, Chen CH, Tsai CH, Tsai FJ (2004) Association between transforming growth factor-beta1 gene C-509T and T869C polymorphisms and rheumatic heart disease. Am Heart J 148:181-186
35. Wong TY, Poon P, Chow KM, Szeto CC, Cheung MK, Li PK (2003) Association of transforming growth factor-beta (TGF-beta) T869C (Leu 10Pro) gene polymorphisms with type 2 diabetic nephropathy in Chinese. Kidney Int 63:1831-1835
36. Sung YK, Hwang SY, Park MK, Farooq M, Han IS, Bae HI, Kim JC, Kim M (2003) Glypican-3 is overexpressed in human hepatocellular carcinoma. Cancer Sci 94:259-262
37. Nagini S, Letchoumy PV, Thangavelu A, Ramachandran CR (2009) Of humans and hamsters: a comparative evaluation of carcinogen activation, DNA damage, cell proliferation, apoptosis, invasion, and angiogenesis in oral cancer patients and hamster buccal pouch carcinomas. Oral Oncol 45:e31-e37