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Volumn 30, Issue 8, 2013, Pages 977-992

Decreased expression and aberrant methylation of Gadd45G is associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma

Author keywords

Esophageal squamous cell carcinoma; Expression; Gadd45; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MESSENGER RNA; TRICHOSTATIN A;

EID: 84890425720     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-013-9597-2     Document Type: Article
Times cited : (26)

References (45)
  • 3
    • 59649103079 scopus 로고    scopus 로고
    • Growth arrest and DNA damage-45 alpha (GADD45alpha)
    • 18760377 10.1016/j.biocel.2008.06.018 1:CAS:528:DC%2BD1MXitVGjt7o%3D
    • Rosemary Siafakas A, Richardson DR (2009) Growth arrest and DNA damage-45 alpha (GADD45alpha). Int J Biochem Cell Biol 41:986-989
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 986-989
    • Rosemary Siafakas, A.1    Richardson, D.R.2
  • 5
    • 0029922537 scopus 로고    scopus 로고
    • The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1
    • 8700517 1:CAS:528:DyaK28XktlKlt7g%3D
    • Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA (1996) The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 12:2579-2594
    • (1996) Oncogene , vol.12 , pp. 2579-2594
    • Vairapandi, M.1    Balliet, A.G.2    Fornace, Jr.A.J.3    Hoffman, B.4    Liebermann, D.A.5
  • 6
    • 0033517293 scopus 로고    scopus 로고
    • CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control
    • 10490824 10.1038/sj.onc.1202885 1:CAS:528:DyaK1MXmt1SrtLo%3D
    • Zhang W, Bae I, Krishnaraju K, Azam N, Fan W, Smith K, Hoffman B, Liebermann DA (1999) CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18:4899-4907
    • (1999) Oncogene , vol.18 , pp. 4899-4907
    • Zhang, W.1    Bae, I.2    Krishnaraju, K.3    Azam, N.4    Fan, W.5    Smith, K.6    Hoffman, B.7    Liebermann, D.A.8
  • 7
    • 69949128251 scopus 로고    scopus 로고
    • Stress sensor Gadd45 genes as therapeutic targets in cancer
    • 19652693 1:CAS:528:DC%2BD1MXot1Snur0%3D
    • Cretu A, Sha X, Tront J, Hoffman B, Liebermann DA (2009) Stress sensor Gadd45 genes as therapeutic targets in cancer. Cancer Ther 7:268-276
    • (2009) Cancer Ther , vol.7 , pp. 268-276
    • Cretu, A.1    Sha, X.2    Tront, J.3    Hoffman, B.4    Liebermann, D.A.5
  • 8
    • 33749023927 scopus 로고    scopus 로고
    • Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence
    • 16951155 10.1158/0008-5472.CAN-06-2013 1:CAS:528:DC%2BD28XovF2isL8%3D
    • Tront JS, Hoffman B, Liebermann DA (2006) Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res 66:8448-8454
    • (2006) Cancer Res , vol.66 , pp. 8448-8454
    • Tront, J.S.1    Hoffman, B.2    Liebermann, D.A.3
  • 9
    • 74949116151 scopus 로고    scopus 로고
    • Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades
    • 20025601 10.2174/156800909790192383 1:CAS:528:DC%2BC3cXhslKnsLs%3D
    • Yang Z, Song L, Huang C (2009) Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades. Curr Cancer Drug Targets 9:915-930
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 915-930
    • Yang, Z.1    Song, L.2    Huang, C.3
  • 10
    • 0036324977 scopus 로고    scopus 로고
    • GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
    • 12124778 10.1002/jcp.10140 1:CAS:528:DC%2BD38XlvFertbY%3D
    • Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol 192:327-338
    • (2002) J Cell Physiol , vol.192 , pp. 327-338
    • Vairapandi, M.1    Balliet, A.G.2    Hoffman, B.3    Liebermann, D.A.4
  • 12
    • 0242322012 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
    • 12933797 10.1074/jbc.M307869200 1:CAS:528:DC%2BD3sXosFSktL8%3D
    • Yoo J, Ghiassi M, Jirmanova L, Balliet AG, Hoffman B, Fornace AJ Jr, Liebermann DA, Bottinger EP, Roberts AB (2003) Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J Biol Chem 278:43001-43007
    • (2003) J Biol Chem , vol.278 , pp. 43001-43007
    • Yoo, J.1    Ghiassi, M.2    Jirmanova, L.3    Balliet, A.G.4    Hoffman, B.5    Fornace, Jr.A.J.6    Liebermann, D.A.7    Bottinger, E.P.8    Roberts, A.B.9
  • 13
    • 25144510121 scopus 로고    scopus 로고
    • The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors
    • 16166418 10.1158/1078-0432.CCR-05-0267 1:CAS:528:DC%2BD2MXhtVShsLfF
    • Ying J, Srivastava G, Hsieh WS, Gao Z, Murray P, Liao SK, Ambinder R, Tao Q (2005) The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clin Cancer Res 11:6442-6449
    • (2005) Clin Cancer Res , vol.11 , pp. 6442-6449
    • Ying, J.1    Srivastava, G.2    Hsieh, W.S.3    Gao, Z.4    Murray, P.5    Liao, S.K.6    Ambinder, R.7    Tao, Q.8
  • 14
    • 77955036478 scopus 로고    scopus 로고
    • Hypermethylation of growth arrest DNA-damage-inducible gene 45 in non-small cell lung cancer and its relationship with clinicopathologic features
    • 20652500 10.1007/s10059-010-0092-1 1:CAS:528:DC%2BC3cXptFGmur8%3D
    • Na YK, Lee SM, Hong HS, Kim JB, Park JY, Kim DS (2010) Hypermethylation of growth arrest DNA-damage-inducible gene 45 in non-small cell lung cancer and its relationship with clinicopathologic features. Mol Cells 30:89-92
    • (2010) Mol Cells , vol.30 , pp. 89-92
    • Na, Y.K.1    Lee, S.M.2    Hong, H.S.3    Kim, J.B.4    Park, J.Y.5    Kim, D.S.6
  • 15
    • 60549108922 scopus 로고    scopus 로고
    • Methylation-mediated repression of GADD45alpha in prostate cancer and its role as a potential therapeutic target
    • 19190346 10.1158/0008-5472.CAN-08-3609 1:CAS:528:DC%2BD1MXhslynsLk%3D
    • Ramachandran K, Gopisetty G, Gordian E, Navarro L, Hader C, Reis IM, Schulz WA, Singal R (2009) Methylation-mediated repression of GADD45alpha in prostate cancer and its role as a potential therapeutic target. Cancer Res 69:1527-1535
    • (2009) Cancer Res , vol.69 , pp. 1527-1535
    • Ramachandran, K.1    Gopisetty, G.2    Gordian, E.3    Navarro, L.4    Hader, C.5    Reis, I.M.6    Schulz, W.A.7    Singal, R.8
  • 16
    • 7244239107 scopus 로고    scopus 로고
    • Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma
    • 15509538 10.1016/S0002-9440(10)63425-6 1:CAS:528:DC%2BD2cXhtVCgsbzE
    • Qiu W, Zhou B, Zou H, Liu X, Chu PG, Lopez R, Shih J, Chung C, Yen Y (2004) Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. Am J Pathol 165:1689-1699
    • (2004) Am J Pathol , vol.165 , pp. 1689-1699
    • Qiu, W.1    Zhou, B.2    Zou, H.3    Liu, X.4    Chu, P.G.5    Lopez, R.6    Shih, J.7    Chung, C.8    Yen, Y.9
  • 17
    • 1342322685 scopus 로고    scopus 로고
    • Loss of expression of the growth inhibitory gene GADD45gamma, in human pituitary adenomas, is associated with CpG island methylation
    • 14647444 10.1038/sj.onc.1207193 1:CAS:528:DC%2BD2cXntlemsQ%3D%3D
    • Bahar A, Bicknell JE, Simpson DJ, Clayton RN, Farrell WE (2004) Loss of expression of the growth inhibitory gene GADD45gamma, in human pituitary adenomas, is associated with CpG island methylation. Oncogene 23:936-944
    • (2004) Oncogene , vol.23 , pp. 936-944
    • Bahar, A.1    Bicknell, J.E.2    Simpson, D.J.3    Clayton, R.N.4    Farrell, W.E.5
  • 18
    • 0035839058 scopus 로고    scopus 로고
    • Genes, genetics, and epigenetics: A correspondence
    • 10.1126/science.293.5532.1103
    • Ct Wu, Morris JR (2001) Genes, genetics, and epigenetics: a correspondence. Science 293:1103-1105
    • (2001) Science , vol.293 , pp. 1103-1105
    • Ct, W.1    Morris, J.R.2
  • 19
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • 12042769 10.1038/nrg962 1:CAS:528:DC%2BD38XksFOmsrw%3D
    • Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415-428
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 20
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • 10729832 10.1016/S0168-9525(99)01971-X 1:CAS:528:DC%2BD3cXit1Sqsbg%3D
    • Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168-174
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 21
    • 4544250024 scopus 로고    scopus 로고
    • Gene-promoter hypermethylation as a biomarker in lung cancer
    • 15343277 10.1038/nrc1432 1:CAS:528:DC%2BD2cXntFCmsbY%3D
    • Belinsky SA (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 4:707-717
    • (2004) Nat Rev Cancer , vol.4 , pp. 707-717
    • Belinsky, S.A.1
  • 22
    • 17844395749 scopus 로고    scopus 로고
    • Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer
    • 15735726 10.1038/sj.onc.1208464 1:CAS:528:DC%2BD2MXjtFOku7g%3D
    • Wang W, Huper G, Guo Y, Murphy SK, Olson JA Jr, Marks JR (2005) Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene 24:2705-2714
    • (2005) Oncogene , vol.24 , pp. 2705-2714
    • Wang, W.1    Huper, G.2    Guo, Y.3    Murphy, S.K.4    Olson, Jr.J.A.5    Marks, J.R.6
  • 24
    • 77954567928 scopus 로고    scopus 로고
    • Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis
    • 20111973 10.1007/s00432-010-0777-z 1:CAS:528:DC%2BC3cXns1ylsbs%3D
    • Zhang W, Li T, Shao Y, Zhang C, Wu Q, Yang H, Zhang J, Guan M, Yu B, Wan J (2010) Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. J Cancer Res Clin Oncol 136:1267-1273
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1267-1273
    • Zhang, W.1    Li, T.2    Shao, Y.3    Zhang, C.4    Wu, Q.5    Yang, H.6    Zhang, J.7    Guan, M.8    Yu, B.9    Wan, J.10
  • 25
    • 0036959841 scopus 로고    scopus 로고
    • Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: Implications for tumorigenesis
    • 11889197 10.1210/jc.87.3.1262 1:CAS:528:DC%2BD38XitlWns78%3D
    • Zhang X, Sun H, Danila DC, Johnson SR, Zhou Y, Swearingen B, Klibanski A (2002) Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. J Clin Endocrinol Metab 87:1262-1267
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1262-1267
    • Zhang, X.1    Sun, H.2    Danila, D.C.3    Johnson, S.R.4    Zhou, Y.5    Swearingen, B.6    Klibanski, A.7
  • 26
    • 0344874654 scopus 로고    scopus 로고
    • Esophageal cancer
    • 14657432 10.1056/NEJMra035010 1:CAS:528:DC%2BD3sXps1WhsL8%3D
    • Enzinger PC, Mayer RJ (2003) Esophageal cancer. N Engl J Med 349:2241-2252
    • (2003) N Engl J Med , vol.349 , pp. 2241-2252
    • Enzinger, P.C.1    Mayer, R.J.2
  • 28
    • 36849094404 scopus 로고    scopus 로고
    • Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China
    • 17653764 10.1007/s00432-007-0283-0 1:CAS:528:DC%2BD2sXhsVSls7fF
    • Guo W, Zhou RM, Wan LL, Wang N, Li Y, Zhang XJ, Dong XJ (2008) Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China. J Cancer Res Clin Oncol 134:263-270
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 263-270
    • Guo, W.1    Zhou, R.M.2    Wan, L.L.3    Wang, N.4    Li, Y.5    Zhang, X.J.6    Dong, X.J.7
  • 29
    • 84862798509 scopus 로고    scopus 로고
    • Concordant promoter methylation of transforming growth factor-beta receptor types i and II occurs early in esophageal squamous cell carcinoma
    • 22314103 10.1097/MAJ.0b013e3182253430
    • Dong Z, Guo W, Guo Y, Kuang G, Yang Z (2012) Concordant promoter methylation of transforming growth factor-beta receptor types I and II occurs early in esophageal squamous cell carcinoma. Am J Med Sci 343:375-381
    • (2012) Am J Med Sci , vol.343 , pp. 375-381
    • Dong, Z.1    Guo, W.2    Guo, Y.3    Kuang, G.4    Yang, Z.5
  • 33
    • 0035964625 scopus 로고    scopus 로고
    • Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer
    • 11592776 10.1054/bjoc.2001.2034 1:STN:280:DC%2BD3Mrks1SgsQ%3D%3D
    • Umemoto M, Yokoyama Y, Sato S, Tsuchida S, Al-Mulla F, Saito Y (2001) Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer. Br J Cancer 85:1032-1036
    • (2001) Br J Cancer , vol.85 , pp. 1032-1036
    • Umemoto, M.1    Yokoyama, Y.2    Sato, S.3    Tsuchida, S.4    Al-Mulla, F.5    Saito, Y.6
  • 34
    • 65249156653 scopus 로고    scopus 로고
    • Aberrant CpG Island hypermethylation of RASSF1A in gastric cardia adenocarcinoma
    • 19160099 10.1080/07357900802620828 1:CAS:528:DC%2BD1MXkt1yisrk%3D
    • Guo W, Dong Z, Chen Z, Yang Z, Wen D, Kuang G, Guo Y, Shan B (2009) Aberrant CpG Island hypermethylation of RASSF1A in gastric cardia adenocarcinoma. Cancer Invest 27:459-465
    • (2009) Cancer Invest , vol.27 , pp. 459-465
    • Guo, W.1    Dong, Z.2    Chen, Z.3    Yang, Z.4    Wen, D.5    Kuang, G.6    Guo, Y.7    Shan, B.8
  • 35
    • 0041422481 scopus 로고    scopus 로고
    • Bisulfite conversion-specific and methylation-specific PCR: A sensitive technique for accurate evaluation of CpG methylation
    • 12951050 10.1016/j.bbrc.2003.08.005 1:CAS:528:DC%2BD3sXmvVKnur8%3D
    • Sasaki M, Anast J, Bassett W, Kawakami T, Sakuragi N, Dahiya R (2003) Bisulfite conversion-specific and methylation-specific PCR: a sensitive technique for accurate evaluation of CpG methylation. Biochem Biophys Res Commun 309:305-309
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 305-309
    • Sasaki, M.1    Anast, J.2    Bassett, W.3    Kawakami, T.4    Sakuragi, N.5    Dahiya, R.6
  • 36
    • 0036856355 scopus 로고    scopus 로고
    • MethPrimer: Designing primers for methylation PCRs
    • 12424112 10.1093/bioinformatics/18.11.1427 1:CAS:528:DC%2BD38XosFOhtb0%3D
    • Li LC, Dahiya R (2002) MethPrimer: designing primers for methylation PCRs. Bioinformatics 18:1427-1431
    • (2002) Bioinformatics , vol.18 , pp. 1427-1431
    • Li, L.C.1    Dahiya, R.2
  • 37
    • 0345603004 scopus 로고    scopus 로고
    • The CpG island searcher: A new WWW resource
    • 12954087 1:CAS:528:DC%2BD3sXovFCqtbc%3D
    • Takai D, Jones PA (2003) The CpG island searcher: a new WWW resource. In Silico Biol 3:235-240
    • (2003) In Silico Biol , vol.3 , pp. 235-240
    • Takai, D.1    Jones, P.A.2
  • 38
    • 0036275374 scopus 로고    scopus 로고
    • Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding
    • 12052864 10.1128/MCB.22.13.4544-4555.2002 1:CAS:528:DC%2BD38Xks1yrsLs%3D
    • Mita H, TsutsuiJ Takekawa M, Witten E, Saito H (2002) Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 22:4544-4555
    • (2002) Mol Cell Biol , vol.22 , pp. 4544-4555
    • Mita, H.1    Tsutsuij, T.M.2    Witten, E.3    Saito, H.4
  • 40
    • 33646437519 scopus 로고    scopus 로고
    • GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability
    • 16353139 10.1002/ijc.21637 1:CAS:528:DC%2BD28XktlGitbc%3D
    • Schneider G, Weber A, Zechner U, Oswald F, Friess HM, Schmid RM, Liptay S (2006) GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. Int J Cancer 118:2405-2411
    • (2006) Int J Cancer , vol.118 , pp. 2405-2411
    • Schneider, G.1    Weber, A.2    Zechner, U.3    Oswald, F.4    Friess, H.M.5    Schmid, R.M.6    Liptay, S.7
  • 42
    • 84862823204 scopus 로고    scopus 로고
    • Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation
    • 10.1186/1756-9966-31-11 10.1186/1756-9966-31-11
    • Bx Wang, Yin BL, He B, Chen C, Zhao M, Wx Zhang, Xia ZK, Yz Pan, Jq Tang, Xm Zhou, Yin N (2012) Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation. J Exp Clin Cancer Res 31:11. doi: 10.1186/1756-9966-31-11
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 11
    • Bx, W.1    Yin, B.L.2    He, B.3    Chen, C.4    Zhao, M.5    Wx, Z.6    Xia, Z.K.7    Yz, P.8    Jq, T.9    Xm, Z.10    Yin, N.11
  • 43
    • 15744392470 scopus 로고    scopus 로고
    • B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest
    • 15644315 10.1074/jbc.M412720200 1:CAS:528:DC%2BD2MXisVOqur4%3D
    • Gao H, Jin S, Song Y, Fu M, Wang M, Liu Z, Wu M, Zhan Q (2005) B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest. J Biol Chem 280:10988-10996
    • (2005) J Biol Chem , vol.280 , pp. 10988-10996
    • Gao, H.1    Jin, S.2    Song, Y.3    Fu, M.4    Wang, M.5    Liu, Z.6    Wu, M.7    Zhan, Q.8
  • 45
    • 37549018861 scopus 로고    scopus 로고
    • A sequential treatment of depsipeptide followed by 5-azacytidine enhances Gadd45beta expression in hepatocellular carcinoma cells
    • 18225533 1:CAS:528:DC%2BD1cXlslaltw%3D%3D
    • Jiang C, Zhou B, Fan K, Heung E, Xue L, Liu X, Kirschbaum M, Yen Y (2007) A sequential treatment of depsipeptide followed by 5-azacytidine enhances Gadd45beta expression in hepatocellular carcinoma cells. Anticancer Res 27:3783-3789
    • (2007) Anticancer Res , vol.27 , pp. 3783-3789
    • Jiang, C.1    Zhou, B.2    Fan, K.3    Heung, E.4    Xue, L.5    Liu, X.6    Kirschbaum, M.7    Yen, Y.8


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