Laser speckle contrast imaging: Theoretical and practical limitations

Journal of Biomedical Optics

Volumn 18, Issue 6, 2013, Pages

  Briers, David ^a   Duncan, Donald D ^b   Hirst, Evan ^c   Kirkpatrick, Sean J ^d   Larsson, Marcus ^e   Steenbergen, Wiendelt ^f   Stromberg, Tomas ^e   Thompson, Oliver B ^c  

^a KINGSTON UNIVERSITY   (United Kingdom)

^b PORTLAND STATE UNIVERSITY   (United States)

^c CALLAGHAN INNOVATION   (New Zealand)

^d Michigan Technological University   (United States)

^e LINKÖPING UNIVERSITY   (Sweden)

^f UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

blood flow; laser Doppler; laser speckle; medical imaging; perfusion; time varying speckle

Indexed keywords

BLOOD FLOW; LASER DOPPLER; LASER SPECKLE; PERFUSION; TIME-VARYING SPECKLE;

DOPPLER EFFECT; HEMODYNAMICS; MEDICAL IMAGING;

SPECKLE;

CONTRAST MEDIUM;

ALGORITHM; BLOOD FLOW; BLOOD FLOW VELOCITY; DOPPLER FLOWMETRY; ERYTHROCYTE; HUMAN; LASER; METHODOLOGY; MICROCIRCULATION; OPTICS; PATHOLOGY; PERFUSION; PHYSIOLOGY; RETINA BLOOD VESSEL; REVIEW; PROCEDURES;

ALGORITHMS; BLOOD FLOW VELOCITY; CONTRAST MEDIA; ERYTHROCYTES; HUMANS; LASERS; MICROCIRCULATION; OPTICS AND PHOTONICS; PERFUSION; REGIONAL BLOOD FLOW; RETINAL VESSELS; ULTRASONOGRAPHY, DOPPLER;

EID: 84890391961     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.18.6.066018     Document Type: Article

References (66)

1. J. W. Goodman, "Statistical properties of laser speckle patterns," in Laser Speckle and Related Phenomena, J. C. Dainty, Ed., Vol. 9 in series Topics in Applied Physics, pp. 9-75, Springer, Berlin, Heidelberg (1975).
2. M. D. Stern, "In vivo evaluation of microcirculation by coherent light scattering," Nature 254, 50-58 (1975).
3. A. F. Fercher and J. D. Briers, "Flow visualization by means of singleexposure speckle photography," Opt. Commun. 37(5), 326-330 (1981). (Pubitemid 11419443)
4. J. D. Briers and S. Webster, "Laser speckle contrast analysis (LASCA): a non-scanning, full-field technique for monitoring capillary blood flow," J. Biomed. Opt. 1(2), 174-179 (1996). (Pubitemid 126649851)
5. R. Bonner and R. Nossal, "Model for laser Doppler measurements of blood-flow in tissue," Appl. Opt. 20(12), 2097-2107 (1981). (Pubitemid 11521007)
6. J. D. Briers, "Laser Doppler and time-varying speckle: a reconciliation," J. Opt. Soc. Am. A 13(2), 345-350 (1996). (Pubitemid 126548531)
7. H. Fujii et al., "Evaluation of blood flow by laser speckle image sensing: part 1," Appl. Opt. 26(24), 5321-5325 (1987).
8. H. Fujii, "Visualization of retinal blood flow by laser speckle flowgraphy," Med. Biol. Eng. Comput. 32(3), 302-304 (1994). (Pubitemid 24198519)
9. Y. Tamaki et al., "Non-contact, two-dimensional measurement of retinal microcirculation using laser speckle phenomenon," Inv. Ophthalmol. Vis. Sci. 35(11), 3825-3834 (1994). (Pubitemid 24334539)
10. N. Konishi and H. Fujii, "Real-time visualization of retinal microcirculation by laser flowgraphy," Opt. Eng. 34(3), 753-757 (1995).
11. T. J. H. Essex and P. O. Byrne, "A laser Doppler scanner for imaging blood flow in skin," J. Biomed. Eng. 13(3), 189-194 (1991).
12. K. Wårdell, A. Jakobsson, and G. E. Nilsson, "Laser Doppler perfusion imaging by dynamic light scattering," IEEE Trans. Biomed. Eng. 40(4), 309-316 (1993). (Pubitemid 24060697)
13. K. Forrester,M. Doschak, and R. Bray, "In vivo comparison of scanning technique and wavelength in laser Doppler perfusion imaging: measurement in knee ligaments in adult rabbits," Med. Biol. Eng. Comput. 35(6), 581-586 (1997). (Pubitemid 27519182)
14. I. Fredriksson, M. Larsson, and T. Strömberg, "Model-based quantitative laser Doppler flowmetry in skin," J. Biomed. Opt. 15(5), 057002 (2010).
15. J. O'Doherty et al., "Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration," J. Biomed. Opt. 14(3), 034025 (2009).
16. E. M. C. Hillman, "Optical brain imaging in vivo: techniques and applications from animal to man," J. Biomed. Opt. 12(5), 051402 (2007).
17. J. D. Briers and A. F. Fercher, "Retinal blood-flow visualization by means of laser speckle photography," Inv. Ophthalmol. Vis. Sci. 22(2), 255-259 (1982). (Pubitemid 12123840)
18. S. Yuan et al., "Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging," Appl. Opt. 44(10), 1823-1830 (2005). (Pubitemid 40479532)
19. A. C. Völker et al., "Laser speckle imaging with an active noise reduction scheme," Opt. Express 13(24), 9782-9787 (2005). (Pubitemid 41692749)
20. A. Serov,W. Steenbergen, and F. de Mul, "Prediction of the photodetector signal generated by Doppler-induced speckle fluctuations: theory and some validations," J. Opt. Soc. A 18(3), 622-630 (2001).
21. R. Bandyopadhyay et al., "Speckle-visibility spectroscopy: a tool to study time-varying dynamics," Rev. Sci. Instrum. 76, 093110 (2005).
22. O. Thompson, M. Andrews, and E. Hirst, "Correction for spatial averaging in laser speckle contrast analysis," Biomed. Opt. Express 2(4), 1021-1029 (2011).
23. A. K. Dunn et al., "Dynamic imaging of cerebral blood flow using laser speckle," J. Cereb. Blood Flow Metab. 21(3), 195-201 (2001). (Pubitemid 32207418)
24. T. Durduran et al., "Spatiotemporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laserspeckle flowmetry," J. Cereb. Blood Flow Metab. 24(5), 518-525 (2004). (Pubitemid 38608283)
25. H. K. Shin et al., "Vasoconstrictive neurovascular coupling during focal ischemic depolarizations," J. Cereb. Blood Flow Metab. 25(1), 1-13 (2005).
26. A. K. Dunn et al., "Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex," Neuroimage 27(2), 279-290 (2005). (Pubitemid 41074831)
27. J. S. Paul et al., "Imaging the development of an ischemic core following photochemically induced cortical infarction in rats using laser speckle contrast analysis (LASCA)," Neuroimage 29(1), 38-45 (2006). (Pubitemid 41828028)
28. P. Zakharov et al., "Dynamic laser speckle imaging of cerebral blood flow," Opt. Express 17(16), 13904-13917 (2009).
29. H. Bolay et al., "Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model," Nat. Med. 8(2), 136-142 (2002). (Pubitemid 34155124)
30. H. Cheng et al., "Laser speckle imaging of blood flow in microcirculation," Phys. Med. Biol. 49(7), 1347-1357 (2004). (Pubitemid 38514796)
31. M. M. Gonik, A. B. Mishkin, and D. A. Zimnyakov, "Visualization of blood microcirculation parameters in human tissues by time-integrated dynamic speckles analysis," Ann. NY Acad. Sci. 972, 325 (2002).
32. F. Domoki et al., "Evaluation of laser-speckle contrast image analysis techniques in the cortical microcirculation of piglets," Microvasc. Res. 83(3), 311-317 (2012).
33. C. Stoianovici, P. Wilder-Smith, and B. Choi, "Assessment of pulpal vitality using laser speckle imaging," Lasers Surg. Med. 43(8), 833-837 (2011).
34. C. J. Stewart et al., "A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging," Burns 31(6), 744-752 (2005). (Pubitemid 41208229)
35. C. J. Stewart et al., "Kinetics of blood flow during healing of excisional full-thickness skin wounds in pigs as monitored by laser speckle perfusion imaging," Skin Res. Technol. 12(4), 247-253 (2006). (Pubitemid 44515671)
36. J. Qin et al., "Hemodynamic and morphological vasculature response to a burn monitored using a combined dual-wavelength laser speckle and optical microangiography imaging system," Biomed. Opt. Express 3(3), 455-466 (2012).
37. M. Nagahara et al., "The acute effects of stellate ganglion block on circulation in human ocular fundus," Acta Ophthalmol. Scand. 79(1), 45-48 (2001). (Pubitemid 32061034)
38. J. Flammer et al., "The impact of ocular blood flow in glaucoma," Prog. Retin. Eye Res. 21(4), 359-393 (2002). (Pubitemid 34879080)
39. A. I. Srienc, Z. L. Kurth-Nelson, and E. A. Newman, "Imaging retinal blood flow with laser speckle flowmetry," Front Neuroenergetics 2, 128 (2010).
40. W. Zhang et al., "Use of the laser speckle flowgraphy in posterior fundus circulation research," Chin. Med. J. (Engl) 124(24), 4339-4344 (2011).
41. A. Aliverdiev, M. Caponero, and C. Moriconi, "Speckle velocimeter for a self-powered vehicle," Tech. Phys. 47(8), 1044-1048 (2002).
42. D. Francis et al., "Objective speckle velocimetry for autonomous vehicle odometer," Appl. Opt. 51(16), 3478-3490 (2012).
43. G. G. Romero, E. E. Alanis, and H. J. Rabal, "Statistics of the dynamic speckle produced by a rotating diffuser and its application to the assessment of paint drying," Opt. Eng. 39(6), 1652-1658 (2000).
44. J. D. Briers, "Laser Doppler, speckle and related techniques for blood perfusionmapping and imaging," Physiol. Meas. 22(4), R35-R66 (2001). (Pubitemid 33104651)
45. J. D. Briers, "Laser speckle contrast imaging for measuring blood flow," Optica Applicata 37(1-2), 139-152 (2007).
46. M. Draijer et al., "Review of laser speckle contrast techniques for visualizing tissue perfusion," Lasers Med. Sci. 24(4), 639-651 (2009).
47. D. A. Boas and A. K. Dunn, "Laser speckle contrast imaging in biomedical optics," J. Biomed. Opt. 15(1), 011109 (2010).
48. K. Basak, M. Manjunatha, and P. K. Dutta, "Review of laser specklebased analysis in medical imaging," Med. Biol. Eng. Comput. 50(6), 547-558 (2012).
49. K. R. Forrester et al., "Comparison of laser speckle and laser Doppler perfusion imaging: measurement in human skin and rabbit articular tissue," Med. Biol. Eng. Comput. 40(6), 687-697 (2002). (Pubitemid 35469958)
50. C. Millet et al., "Comparison between laser speckle contrast imaging and laser Doppler imaging to assess skin blood flow in humans," Microvasc. Res. 82(2), 147-151 (2011).
51. G. A. Tew et al., "Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function," Microvasc. Res. 82(3), 326-332 (2011).
52. D. D. Duncan and S. J. Kirkpatrick, "Can laser speckle flowmetry be made a quantitative tool?," J. Opt. Soc. Am. A 25(8), 2088-2094 (2008).
53. J.W. Goodman, "Some effects of target-induced scintillations on optical radar performance," Proc. IEEE 53(11), 1688-1700 (1965).
54. J. W. Goodman, Statistical Optics, Wiley & Sons, New York (1985).
55. P. A. Lemieux and D. J. Durian, "Investigating non-Gaussian scattering processes by using nth-order intensity correlation functions," J. Opt. Soc. Am. A 16(7), 1651-1654 (1999).
56. D. D. Duncan, S. J. Kirkpatrick, and R. K. Wang, "Statistics of local speckle contrast," J. Opt. Soc. Am. A 25(1), 9-15 (2008). (Pubitemid 351325092)
57. J. D. Briers, "Statistics of fluctuation speckle patterns produced by a mixture of moving and stationary scatterers," Opt. Quant. Electron. 10(4), 364-366 (1978).
58. H. J. Rabal et al., "Numerical model for dynamic speckle: an approach using the movement of the scatterers," J. Opt. A: Pure & Appl. Opt. 5(5), S381-385 (2003).
59. P. Zakharov et al., "Quantitative modelling of laser speckle imaging," Opt. Lett. 31(23), 3465-3467 (2006). (Pubitemid 46034608)
60. P. Zakharov and F. Scheffold, "Advances in dynamic light scattering techniques," in Light Scattering Reviews 4, A. A. Kokhanovsky, Ed., pp. 433-467, Springer, Heidelberg (2009).
61. S. J. Kirkpatrick, D. D. Duncan, and E. M. Wells-Gray, "Detrimental effects of speckle-pixel size matching in laser speckle contrast imaging," Opt. Lett. 33(24), 2886-2888 (2008).
62. O. B. Thompson and M. K. Andrews, "Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler-like spectra," J. Biomed. Opt. 15(2), 027015 (2010).
63. A. B. Parthasarathy et al., "Robust flow measurement with multiexposure speckle imaging," Opt. Express 16(3), 1975-1989 (2008). (Pubitemid 351240039)
64. D. J. Cuccia et al., "Quantitation and mapping of tissue optical properties using modulated imaging," J. Biomed. Opt. 14(2), 024012 (2009).
65. M. J. Draijer et al., "Relation between the contrast in time integrated dynamic speckle patterns and the power spectral density of their temporal intensity fluctuations," Opt. Express 18(2), 21883-21891 (2010).
66. M. Draijer et al., "Twente optical perfusion camera: system overview and performance for video rate laser Doppler perfusion imaging," Opt. Express 17(5), 3211-3225 (2009).