Kinetics of blood flow during healing of excisional full-thickness skin wounds in pigs as monitored by laser speckle perfusion imaging

Skin Research and Technology

Volumn 12, Issue 4, 2006, Pages 247-253

  Stewart, C J ^a   Gallant Behm, C L ^a   Forrester, K ^a   Tulip, J ^a   Hart, D A ^a   Bray, R C ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Blood flow; Laser speckle perfusion imaging (LSPI); Porcine model; Wound healing

Indexed keywords

BLOOD FLOW; LASER DOPPLER IMAGING; LASER SPECKLE PERFUSION IMAGING (LSPI); WOUND HEALING;

BIOMEDICAL ENGINEERING; DERMATOLOGY; LASER APPLICATIONS; MATHEMATICAL MODELS; SKIN;

HEMODYNAMICS;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPITHELIZATION; EXPERIMENTAL MODEL; FEMALE; FLOW KINETICS; HELIUM NEON LASER; LASER DOPPLER FLOWMETRY; NON INVASIVE MEASUREMENT; NONHUMAN; PHOTOGRAPHY; REPRODUCIBILITY; SKIN BLOOD FLOW; SKIN INJURY; SWINE; TISSUE PERFUSION; WOUND HEALING;

ANIMALS; EQUIPMENT DESIGN; FEMALE; KINETICS; LASERS; REGIONAL BLOOD FLOW; RHEOLOGY; SKIN; SWINE; TIME FACTORS; WOUND HEALING; WOUNDS, PENETRATING;

EID: 33749466716     PISSN: 0909752X     EISSN: 16000846     Source Type: Journal    
DOI: 10.1111/j.0909-752X.2006.00157.x     Document Type: Article

References (27)

1. Silverstein P, Goodwin M, Raulston G, Pruitt B. Hypertrophic scar in the experimental animal. In: Longacre JJ, ed. The Ultrastructure of Collagen. 1973: 213-236.
2. Matsumura H, Engrav L, Yunusov M, Reichenbach D, Gibran N, Maser B. Cones, fat domes and hypertrophic scarring in the female, red Duroc pig. Burn Care Rehab 1999; 20: S214.
3. Gallant CL, Olson ME, Hart DA. Molecular, histologic, and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring. Wound Repair Regen 2004; 12: 305-319.
4. Gallant-Behm CL, Olsen ME, Hart DA. Cytokine and growth factor mRNA expression patterns associated with the hypercontracted, hyperpigmented scarring phenotype of red Duroc pigs: A model of human abnormal scar development? J Cutaneous Med Surg 2005; 9: 165-177.
5. Gallant-Behm CL, Hart DA. Genetic analysis of skin wound healing and scarring in a porcine model. Wound Repair Regen 2006; 14: 46-54.
6. Marneros AG, Norris JE, Olsen BR et al. Clinical genetics of familial keloids. Arch Dermatol 2001; 137: 1429-1434.
7. Eskild-Jensen A, Koff J, Kjolseth D et al. Endogenous TGF-beta 1 and TGF-beta 2 are not essential for epithelialization and neovascularization in the hairless mouse ear wound model. Ann Chir Gynaecol 1997; 86: 248-254.
8. Forrester KR, Stewart C, Tulip J et al. Comparison of laser speckle and laser Doppler perfusion imaging: Measurement in human skin and rabbit articular tissue. Med Biol Eng Comput 2002; 40: 687-697.
9. Forrester KR, Tulip J, Leonard C, Stewart C, Bray RC. A laser speckle imaging technique for measuring tissue perfusion. IEEE Trans Biomed Eng 2004; 51: 1994-2005.
10. Essex TJH, Byrne P. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng 1991; 14: 189-194.
11. Wardell K, Jakobsson A, Nilsson GE. Laser Doppler perfusion imaging by dynamic light scattering. IEEE Trans Biomed Eng 1993; 40: 309-316.
12. Fercher AF, Briers JD. Flow visualization by means of single-exposure photography. Opt Commun 1991; 37: 326-330.
13. Briers JD, Fercher AF. Retinal blood-flow visualization by means of laser speckle photography. Invest Ophthalmol Vis Sci 1982; 22: 255-259.
14. Briers JD, Webster S. Quasi real-time digital version of single-exposure speckle photography for full-field monitoring of velocity or flow fields. Opt Commun 1995; 116: 36-42.
15. Briers JD, Richards GR, He XW. Capillary blood flow monitoring using laser speckle contrast analysis (LASCA). J Biomed Opt 1999; 4: 164-175.
16. Ruth B. Measuring the steady-state value and the dynamics of the skin blood flow using the non-contact laser speckle method. Med Eng Phys 1994; 16: 105-111.
17. Dunn AK, Bolay H, Moskowitz MA, Boas DA. Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 2001; 21: 195-201.
18. Cheng H, Luo Q, Liu Q, Lu Q, Gong H, Zeng S. Laser speckle imaging of blood flow in microcirculation. Phys Med Biol 2004; 49: 1347-1357.
19. Choi B, Kang NM, Nelson JS. Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model. Microvasc Res 2004; 68: 143-146.
20. Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H. Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res 1995; 60: 373-383.
21. Yaoeda K, Shirakashi M, Funaki S, Funaki H, Nakatsue T, Fukushima A, Abe H. Measurement of microcirculation in optic nerve head by laser speckle flowgraphy in normal volunteers. Am J Ophthalmol 2000; 130: 606-610.
22. Forrester KR, Stewart C, Leonard C, Tulip J, Bray RC. Endoscopic laser imaging of tissue perfusion: New instrumentation and technique. Lasers Surg Med 2003; 33: 151-157.
23. Kischer CW. The microvessels in hypertrophic scars, keloids and related lesions: A review. J Submicrosc Cytol Pathol 1992; 24: 281-296.
24. Bray R, Forrester K, Leonard C, McArthur R, Tulip J, Lindsay R. Laser Doppler imaging of burn scars: A comparison of wavelength and scanning methods. Burns 2003; 29: 199-206.
25. Stewart C, Frank R, Forrester K, Tulip J, Lindsay R, Bray RC. A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging. Burns 2004; in press.
26. Wang JF, Olson ME, Reno CR et al. Molecular and cell biology of skin wound healing in a pig model. Connect Tissue Res 2000; 41: 195-211.
27. Wang JF, Olson ME, Reno CR et al. The pig as a model for excisional skin wound healing: Characterization of the molecular and cellular biology, and bacteriology of the healing process. Comp Med 2001; 51: 341-348.