In vitro assessment of cytotoxicity and carcinogenic potential of chemicals: Evaluation of the cytotoxicity induced by 58 metal compounds in the Balb/3T3 cell line

Alternatives to Laboratory Animals

Volumn 29, Issue 5, 2001, Pages 601-611

  Mazzotti, F ^a   Sabbioni, E ^a   Ghiani, M ^a   Cocco, B ^a   Ceccatelli, R ^a   Fortaner, S ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

Balb c 3T3 assay; Carcinogenic potential; In vitro cytotoxicity; Trace metals

Indexed keywords

METAL DERIVATIVE; TRACE METAL;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; CYTOTOXICITY; FIBROBLAST; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT; SPECIES DIFFERENTIATION;

EID: 0034764179     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290102900509     Document Type: Article

References (29)

1. Carcinogenicity, mutagenicity and teratogenicity of industrially used metals
2. Carcinogenic effects of metals
3. IARC monographs on the evaluation of carcinogenic risks to humans and their supplements: A complete list
4. Interaction and distinction of genotoxic and nongenotoxic events in carcinogenesis
5. Cell transformation assays as predictors of human carcinogenicity. The conclusions and recommendations of ECVAM Workshop 39
6. Transformation of Balb/c 3T3 cells. IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure
7. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts
8. Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation
9. Cellular retention, cytotoxicity and morphological transformation by vanadium(IV) in Balb/3T3 cell lines
10. The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals
11. Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds
12. The IMETOX project (In Vitro MEtal TOXicology)
13. Application of the Three Rs in toxicology
14. Practical aspects of the validation of toxicity test procedures. The conclusions and recommendations of ECVAM Workshop 5
15. Quantitation of chemically induced neoplastic transformation of Balb/3T3 cloned cell lines
16. Chemical-induced transformation in Balb/c-3T3 cells: Relationship between in vitro transformation and cytotoxicity, carcinogenesis, and genotoxicity
17. An interlaboratory validation study of the improved transformation assay employing Balb/c 3T3 cells: Results of a collaborative study on the two-stage cell transformation assay by the Nongenotoxic Carcinogen Study Group
18. The intensity of vanadium (V)-induced cytotoxicity and morphological transformation in Balb/3T3 cells is dependent on glutathione-mediated bioreduction to vanadium(IV)
19. Quantitative studies on cytotoxicity and neoplastic transformation of Balb/3T3 cells by trace metals
20. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts
21. Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo(α)pyrene
22. Cytotoxic and neoplastic transforming effects of industrial hexavalent chromium pigments in Syrian hamster embryo cells
23. Vanadium compounds promote the induction of morphological transformation of hamster embryo cells with no effect on gap junctional cell communication
24. Assessment of two alternative methods for predicting the in vivo toxicities of metallic compounds
25. Trace metal speciation in environmental toxicology research
26. Effects of fungizone on the in vitro cytotoxicity of other chemicals
27. Cellular and molecular mechanisms of cell transformation and standardisation of transformation assays of established cell lines for the prediction of carcinogenic chemicals: Overview and recommended protocols