Contrast-Enhanced Nanofocus X-Ray Computed Tomography Allows Virtual Three-Dimensional Histopathology and Morphometric Analysis of Osteoarthritis in Small Animal Models

Cartilage

Volumn 5, Issue 1, 2014, Pages 55-65

  Kerckhofs, Greet ^a,b   Sainz, Julie ^c   Maréchal, Marina ^b   Wevers, Martine ^b   Van de Putte, Tom ^c   Geris, Liesbet ^a,b   Schrooten, Jan ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c TiGenix   (Belgium)

Author keywords

3D cartilage quantification; contrast enhanced nanofocus computed tomography (CE nanoCT); modified Mankin scoring; osteoarthritis; virtual histopathology

Indexed keywords

CONTRAST MEDIUM; GLYCOSAMINOGLYCAN; MEGLUMINE IOXAGLATE PLUS SODIUM IOXAGLATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE INJURY; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCED NANOFOCUS X RAY COMPUTED TOMOGRAPHY; CONTROLLED STUDY; HISTOLOGY; HISTOPATHOLOGY; MANKIN SCORING; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOARTHRITIS; SCORING SYSTEM; THREE DIMENSIONAL IMAGING; ADULT; ARTICULAR CARTILAGE; BONE MASS; BONE STRUCTURE; CARTILAGE THICKNESS; IMAGE QUALITY; JOINT FUNCTION; JOINT STABILITY; MEDIAL MENISCUS DESTABILIZATION; MODIFIED MANKIN SCORING; MUSCULOSKELETAL SYSTEM PARAMETERS;

EID: 84890383158     PISSN: 19476035     EISSN: 19476043     Source Type: Journal    
DOI: 10.1177/1947603513501175     Document Type: Article

References (28)

1. Bijlsma JW,Berenbaum F,Lafeber FP.Osteoarthritis: an update with relevance for clinical practice.Lancet. 2011;377:2115-26.
2. Gelber AC,Hochberg MC,Mead LA,Wang NY,Wigley FM,Klag MJ.Joint injury in young adults and risk for subsequent knee and hip osteoarthritis.Ann Intern Med. 2000;133:321-8.
3. Messner K,Maletius W.The long-term prognosis for severe damage to weight-bearing cartilage in the knee: a 14-year clinical and radiographic follow-up in 28 young athletes.Acta Orthop Scand. 1996;67:165-8.
4. Maréchal M,Van Hauwermeiren H,Neys J,Vanderlinden G,Van de,Putte T.In vivo evaluation of different surgical procedures for autologous chondrocyte implantation.Cartilage. 2013;4:83-90.
5. Christiansen BA,Anderson MJ,Lee CA,Williams JC,Yik JH,Haudenschild DR.Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis.Osteoarthritis Cartilage. 2012;20:773-82.
6. Kozawa E,Nishida Y,Cheng XW,Urakawa H,Arai E,Futamura N, et al.Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis. Arthritis Rheum. 2012;64:454-64.
7. Botter SM,Glasson SS,Hopkins B,Clockaerts S,Weinans H,van Leeuwen JP.ADAMTS5-/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes.Osteoarthritis Cartilage. 2009;17:636-45.
8. Furman BD,Strand J,Hembree WC,Ward BD,Guilak F,Olson SA.Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis.J Orthop Res. 2007;25:578-92.
9. Mankin HJ,Dorfman H,Lippiello L,Zarins A.Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.J Bone Joint Surg Am. 1971;53:523-37.
10. Glasson SS,Chambers MG,Van Den Berg WB,Little CB.The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse.Osteoarthritis Cartilage. 2010;18:S17-23.
11. Marenzana M,Hagen CK,Das Neves Borges P,Endrizzi M,Szafraniec MB,Ignatyev K, et al.Visualization of small lesions in rat cartilage by means of laboratory-based x-ray phase contrast imaging. Phys Med Biol. 2012;57:8173-84.
12. Xie L,Lin ASP,Levenston ME,Guldberg RE.Quantitative assessment of articular cartilage morphology via EPIC-microCT.Osteoarthritis Cartilage. 2009;17:313-20.
13. Piscaer TM,Waarsing JH,Kops N,Pavljasevic P,Verhaar JA,van Osch GJ, et al.In vivo imaging of cartilage degeneration using microCT-arthrography. Osteoarthritis Cartilage. 2008;16:1011-7.
14. Palmer AW,Guldberg RE,Levenston ME.Analysis of cartilage matrix fixed charge density and three-dimensional morphology via contrast-enhanced microcomputed tomography.Proc Natl Acad Sci U S A. 2006;103:19255-60.
15. Kotwal N,Li J,Sandy J,Plaas A,Sumner DR.Initial application of EPIC-μCT to assess mouse articular cartilage morphology and composition: effects of aging and treadmill running.Osteoarthritis Cartilage. 2012;20:887-95.
16. Silvast TS,Jurvelin JS,Tiitu V,Quinn TM,Töyräs J.Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro.Cartilage. 2013;4:42-51.
17. Bansal PN,Stewart RC,Entezari V,Snyder BD,Grinstaff MW.Contrast agent electrostatic attraction rather than repulsion to glycosaminoglycans affords a greater contrast uptake ratio and improved quantitative CT imaging in cartilage.Osteoarthritis Cartilage. 2011;19:970-6.
18. Gu XI,Palacio-Mancheno PE,Leong DJ,Borisov YA,Williams E,Maldonado N, et al.High resolution micro arthrography of hard and soft tissues in a murine model. Osteoarthritis Cartilage. 2012;20:1011-9.
19. Xie L,Lin ASP,Guldberg RE,Levenston ME.Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-mu CT.Osteoarthritis Cartilage. 2010;18:65-72.
20. Kerckhofs G,Sainz J,Wevers M,Van de,Putte T,Schrooten J.Contrast-enhanced nanofocus computed tomography images the cartilage subtissue architecture in three dimensions.Eur Cell Mater. 2013;25:179-89.
21. Glasson SS,Blanchet TJ,Morris EA.The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse.Osteoarthritis Cartilage. 2007;15:1061-9.
22. Stewart RC,Bansal PN,Entezari V,Lusic H,Nazarian RM,Snyder BD, et al.Contrast-enhanced CT with a high-affinity cationic contrast agent for imaging ex vivo bovine, intact ex vivo rabbit, and in vivo rabbit cartilage.Radiology. 2013;266:141-50.
23. Otsu N.Threshold selection method from gray-level histograms.IEEE Trans Syst Man Cybern. 1979;9:62-6.
24. Hildebrand T,Rüegsegger P.A new method for the model-independent assessment of thickness in three-dimensional images.J Microsc Oxford. 1997;185:67-75.
25. Janes KA,Albeck JG,Gaudet S,Sorger PK,Lauffenburger DA,Yaffe MB.A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.Science. 2005;310:1646-53.
26. Miller-Jensen K,Janes KA,Brugge JS,Lauffenburger DA.Common effector processing mediates cell-specific responses to stimuli.Nature. 2007;448:604-8.
27. Platt MO,Wilder CL,Wells A,Griffith LG,Lauffenburger DA.Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.Stem Cells. 2009;27:2804-14.
28. Janes KA,Kelly JR,Gaudet S,Albeck JG,Sorger PK,Lauffenburger DA.Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data.J Comput Biol. 2004;11:544-61.