Clinical significance of ghrelin expression in the gastric mucosa of morbidly obese patients

World Journal of Surgery

Volumn 37, Issue 12, 2013, Pages 2883-2890

  Miyazaki, Yasuhiro ^a   Takiguchi, Shuji ^a   Seki, Yosuke ^b   Kasama, Kazunori ^b   Takahashi, Tsuyoshi ^a   Kurokawa, Yukinori ^a   Yamasaki, Makoto ^a   Miyata, Hiroshi ^a   Nakajima, Kiyokazu ^a   Mori, Masaki ^a   Doki, Yuichiro ^a  

^a OSAKA UNIVERSITY   (Japan)

^b Yotsuya Medical Cube   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GHRELIN;

ADULT; AGED; CASE CONTROL STUDY; CLINICAL TRIAL; FEMALE; FOLLOW UP; GASTRECTOMY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; OBESITY, MORBID; PROCEDURES; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA; TREATMENT OUTCOME; WEIGHT REDUCTION;

ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; GASTRECTOMY; GASTRIC MUCOSA; GHRELIN; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; OBESITY, MORBID; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84890382877     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-013-2209-0     Document Type: Article

References (35)

1. Buchwald H, Avidor Y, Braunwald E et al (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724-1737
2. Sjostrom L, Narbro K, Sjostrom CD et al (2007) Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741-752
3. Christou NV, Sampalis JS, Liberman M et al (2004) Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients. Ann Surg 240:416-423 (discussion 423-414)
4. Perry CD, Hutter MM, Smith DB et al (2008) Survival and changes in comorbidities after bariatric surgery. Ann Surg 247:21-27
5. Marceau P, Biron S, Bourque RA et al (1993) Biliopancreatic diversion with a new type of gastrectomy. Obes Surg 3:29-35
6. Cottam D, Qureshi FG, Mattar SG et al (2006) Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc 20:859-863
7. Menenakos E, Stamou KM, Albanopoulos K et al (2010) Laparoscopic sleeve gastrectomy performed with intent to treat morbid obesity: a prospective single-center study of 261 patients with a median follow-up of 1 year. Obes Surg 20:276-282
8. Uglioni B, Wolnerhanssen B, Peters T et al (2009) Midterm results of primary vs. secondary laparoscopic sleeve gastrectomy (LSG) as an isolated operation. Obes Surg 19:401-406
9. Gagner M, Deitel M, Kalberer TL et al (2009) The Second International Consensus Summit for Sleeve Gastrectomy, March 19-21, 2009. Surg Obes Relat Dis 5:476-485
10. Akkary E, Duffy A, Bell R (2008) Deciphering the sleeve: technique, indications, efficacy, and safety of sleeve gastrectomy. Obes Surg 18:1323-1329
11. Bohdjalian A, Langer FB, Shakeri-Leidenmuhler S et al (2010) Sleeve gastrectomy as sole and definitive bariatric procedure: 5-year results for weight loss and ghrelin. Obes Surg 20:535-540
12. Langer FB, Reza Hoda MA, Bohdjalian A et al (2005) Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg 15:1024-1029
13. Tschop M, Weyer C, Tataranni PA et al (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
14. Ueno H, Yamaguchi H, Kangawa K et al (2005) Ghrelin: a gastric peptide that regulates food intake and energy homeostasis. Regul Pept 126:11-19
15. Takiguchi S, Adachi S, Yamamoto K et al (2012) Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers. Dig Dis Sci 57:1238-1246
16. Regan JP, Inabnet WB, Gagner M et al (2003) Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg 13:861-864
17. Kasama K, Tagaya N, Kanehira E et al (2009) Laparoscopic sleeve gastrectomy with duodenojejunal bypass: technique and preliminary results. Obes Surg 19:1341-1345
18. Akamizu T, Shinomiya T, Irako T et al (2005) Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab 90:6-9
19. Hosoda H, Kojima M, Matsuo H et al (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913
20. Nagaya N, Kojima M, Uematsu M et al (2001) Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol 280:R1483-R1487
21. Kojima M, Hosoda H, Date Y et al (1999) Ghrelin is a growth-hormone- releasing acylated peptide from stomach. Nature 402:656-660
22. Akamizu T, Kangawa K (2006) Translational research on the clinical applications of ghrelin. Endocr J 53:585-591
23. Fujitsuka N, Asakawa A, Amitani H et al (2012) Ghrelin and gastrointestinal movement. Methods Enzymol 514:289-301
24. Nagaya N, Uematsu M, Kojima M et al (2001) Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104:1430-1435
25. Miki K, Maekura R, Nagaya N et al (2012) Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial. PLoS One 7:e35708
26. Li WG, Gavrila D, Liu X et al (2004) Ghrelin inhibits proinflammatory responses and nuclear factor-kappaβ activation in human endothelial cells. Circulation 109:2221-2226
27. Cummings DE, Weigle DS, Frayo RS et al (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
28. Goitein D, Lederfein D, Tzioni R et al (2012) Mapping of ghrelin gene expression and cell distribution in the stomach of morbidly obese patients: a possible guide for efficient sleeve gastrectomy construction. Obes Surg 22:617-622
29. Maksud FA, Alves JS, Diniz MT et al (2011) Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients. Eur J Endocrinol 165:57-62
30. Akamizu T, Kangawa K (2011) Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect. Peptides 32:2295-2300
31. Zub-Pokrowiecka A, Rembiasz K, Konturek SJ et al (2010) Ghrelin in diseases of the gastric mucosa associated with Helicobacter pylori infection. Med Sci Monit 16:CR493-CR500
32. Natalucci G, Riedl S, Gleiss A et al (2005) Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol 152:845-850
33. Spiegel K, Tasali E, Leproult R et al (2011) Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J Clin Endocrinol Metab 6:486-493
34. Goel N, Stunkard AJ, Rogers NL et al (2009) Circadian rhythm profiles in women with night eating syndrome. J Biol Rhythms 24:85-94
35. Deitel M (2003) Overweight and obesity worldwide now estimated to involve 1.7 billion people. Obes Surg 13:329-330