Hypoglycaemic events in patients with type 2 diabetes in the United Kingdom: Associations with patient-reported outcomes and self-reported HbA1c

BMC Endocrine Disorders

Volumn 13, Issue , 2013, Pages

  Mitchell, Beth D ^a   Vietri, Jeffrey ^b   Zagar, Anthony ^a   Curtis, Bradley ^a   Reaney, Matthew ^a  

^a ELI LILLY AND COMPANY   (United States)

^b KANTAR HEALTH   (United States)

Author keywords

Health related quality of life; Hypoglycaemia; Hypoglycaemia fear; Hypoglycaemic events; Treatment satisfaction

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; ARTICLE; COMPARATIVE STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DIZZINESS; EATING HABIT; EXERCISE; FEAR; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEALTH CARE UTILIZATION; HEALTH STATUS; HOSPITALIZATION; HUMAN; HYPOGLYCEMIA; LEISURE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PATIENT SATISFACTION; PERSONAL EXPERIENCE; QUALITY OF LIFE; SELF REPORT; SHOPPING; STRESS; SWEATING; UNITED KINGDOM; WEAKNESS;

EID: 84890361226     PISSN: None     EISSN: 14726823     Source Type: Journal    
DOI: 10.1186/1472-6823-13-59     Document Type: Article

References (41)

1. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008, 358:2560-2572.
2. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993, 329:977-986.
3. Durante AJ, Selwyn PA, O'Connor PG. Risk factors for and knowledge of Mycobacterium tuberculosis infection among drug users in substance abuse treatment. Addiction 1998, 93:1393-1401. 10.1046/j.1360-0443.1998.939139310.x, 9926545.
4. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003, 348:383-393. 10.1056/NEJMoa021778, 12556541.
5. Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 2000, 23(Suppl 2):B21-B29.
6. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995, 28:103-117. 10.1016/0168-8227(95)01064-K, 7587918.
7. Gerstein HC, Miller ME, Byington RP, Goff DC, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008, 358:2545-2559.
8. Kelly TN, Bazzano LA, Fonseca VA, Thethi TK, Reynolds K, He J. Systematic review: glucose control and cardiovascular disease in type 2 diabetes. Ann Intern Med 2009, 151:394. 10.7326/0003-4819-151-6-200909150-00137, 19620144.
9. Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009, 360:129-139. 10.1056/NEJMoa0808431, 19092145.
10. Currie CJ, Peters JR, Tynan A, Evans M, Heine RJ, Bracco OL, Zagar T, Poole CD. Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. Lancet 2010, 375:481-489. 10.1016/S0140-6736(09)61969-3, 20110121.
11. Harris MI. Health care and health status and outcomes for patients with type 2 diabetes. Diabetes Care 2000, 23:754. 10.2337/diacare.23.6.754, 10840991.
12. Saaddine JB, Engelgau MM, Beckles GL, Gregg EW, Thompson TJ, Narayan K. A diabetes report card for the United States: quality of care in the 1990s. Ann Intern Med 2002, 136:565. 10.7326/0003-4819-136-8-200204160-00005, 11955024.
13. Blak BT, Smith HT, Hards M, Maguire A, Gimeno V. A retrospective database study of insulin initiation in patients with Type 2 diabetes in UK primary care. Diabet Med 2012, 29:e191-e198. 10.1111/j.1464-5491.2012.03694.x, 22507537.
14. Holman RR, Farmer AJ, Davies MJ, Levy JC, Darbyshire JL, Keenan JF, Paul SK. Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 2009, 361:1736-1747. 10.1056/NEJMoa0905479, 19850703.
15. Alvarez Guisasola F, Tofe Povedano S, Krishnarajah G, Lyu R, Mavros P, Yin D. Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study. Diabetes Obes Metab 2008, 10(Suppl 1):25-32.
16. Ross SA, Tildesley HD, Ashkenas J. Barriers to effective insulin treatment: the persistence of poor glycemic control in type 2 diabetes. Curr Med Res Opin 2011, 27(Suppl 3):13-20.
17. Leiter LA, Yale J, Chiasson J, Harris SB, Kleinstiver P, Sauriol L. Assessment of the impact of fear of hypoglycemic episodes on glycemic and hypoglycemia management. Can J Diabetes 2005, 29:186-192.
18. Wild D, von Maltzahn R, Brohan E, Christensen T, Clauson P, Gonder-Frederick L. A critical review of the literature on fear of hypoglycemia in diabetes: Implications for diabetes management and patient education. Patient Educ Couns 2007, 68:10-15. 10.1016/j.pec.2007.05.003, 17582726.
19. Peyrot M, Barnett A, Meneghini L, Schumm-Draeger PM. Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study. Diabet Med 2012, 29:682-689. 10.1111/j.1464-5491.2012.03605.x, 3433794, 22313123.
20. Williams SA, Pollack MF, DiBonaventura M. Effects of hypoglycemia on health-related quality of life, treatment satisfaction and healthcare resource utilization in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 2011, 91:363-370. 10.1016/j.diabres.2010.12.027, 21251725.
21. Brod M, Skovlund SE, Wittrup-Jensen KU. Measuring the impact of diabetes through patient report of treatment satisfaction, productivity and symptom experience. Qual Life Res 2006, 15:481-491. 10.1007/s11136-005-1624-6, 16547787.
22. Marrett E, Radican L, Davies MJ, Zhang Q. Assessment of severity and frequency of self-reported hypoglycemia on quality of life in patients with type 2 diabetes treated with oral antihyperglycemic agents: a survey study. BMC Res Notes 2011, 4:251. 10.1186/1756-0500-4-251, 3148563, 21777428.
23. Williams SA, Shi L, Brenneman SK, Johnson JC, Wegner JC, Fonseca V. The burden of hypoglycemia on healthcare utilization, costs, and quality of life among type 2 diabetes mellitus patients. J Diabetes Complications 2012, 26:399-406. 10.1016/j.jdiacomp.2012.05.002, 22699113.
24. Sheu WH, Ji LN, Nitiyanant W, Baik SH, Yin D, Mavros P, Chan SP. Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region. Diabetes Res Clin Pract 2012, 96:141-148. 10.1016/j.diabres.2011.12.027, 22265956.
25. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994, 47:1245-1251. 10.1016/0895-4356(94)90129-5, 7722560.
26. Rabin R, Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001, 33:337-343. 10.3109/07853890109002087, 11491192.
27. Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993, 4:353. 10.2165/00019053-199304050-00006, 10146874.
28. Anderson RT, Girman CJ, Pawaskar MD, Camacho FT, Calles J, Kelly WS, DeMuro C, Balkrishnan R. Diabetes Medication Satisfaction Tool: a focus on treatment regimens. Diabetes Care 2009, 32:51-53. 10.2337/dc08-0856, 2606829, 18931098.
29. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986, 24:67-74. 10.1097/00005650-198601000-00007, 3945130.
30. Morisky DE, Malotte CK, Choi P, Davidson P, Rigler S, Sugland B, Langer M. A patient education program to improve adherence rates with antituberculosis drug regimens. Health Educ Behav 1990, 17:253.
31. Cox DJ, Irvine A, Gonder-Frederick L, Nowacek G, Butterfield J. Fear of hypoglycemia: quantification, validation, and utilization. Diabetes Care 1987, 10:617-621. 10.2337/diacare.10.5.617, 3677982.
32. Walters SJ, Brazier JE. Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res 2005, 14:1523-1532. 10.1007/s11136-004-7713-0, 16110932.
33. McEwen LN, Kim C, Haan MN, Ghosh D, Lantz PM, Thompson TJ, Herman WH. Are health-related quality-of-life and self-rated health associated with mortality? Insights from Translating Research Into Action for Diabetes (TRIAD). Prim Care Diabetes 2009, 3:37-42. 10.1016/j.pcd.2009.01.001, 19269911.
34. Norman GR, Sloan JA, Wyrwich KW. The truly remarkable universality of half a standard deviation: confirmation through another look. Expert Rev Pharmacoecon Outcomes Res 2004, 4:581-585. 10.1586/14737167.4.5.581, 19807551.
35. Clarke PM, Hayes AJ, Glasziou PG, Scott R, Simes J, Keech AC. Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. Med Care 2009, 47:61-68. 10.1097/MLR.0b013e3181844855, 19106732.
36. Cohen J. Statistical power analysis for the behavioral sciences 1988, Hillsdale, NJ: Lawrence Erlbaum, 2.
37. Lipska KJ, Warton EM, Huang ES, Moffet HH, Inzucchi SE, Krumholz HM, Karter AJ. HbA1c and risk of severe hypoglycemia in type 2 diabetes: the diabetes and aging study. Diabetes Care 2013, 36:3535-3542. 10.2337/dc13-0610, 23900589.
38. Mancia G, Grassi G. Protection of patients with diabetes, with or without hypertension: implications of ADVANCE for clinical practice. J Hypertens Suppl 2009, 27:S19-S23.
39. Ritholtz MD, Jacobson AM. Living with hypoglycemia. J Gen Intern Med 1998, 13:799-804. 10.1046/j.1525-1497.1998.00243.x, 1497041, 9844077.
40. Richmond J. Effects of hypoglycaemia: patient's perceptions and experiences. Br J Nurs 1996, 5:1054-1059.
41. Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, Heller SR, Rodriguez H, Rosenzweig J, Vigersky R. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and The Endocrine Society. Diabetes Care 2013, 36:1384-1395. 10.2337/dc12-2480, 23589542.