Metabolic enzyme activities and drug excretion in the small intestine and in the liver in the rat

Acta Physiologica Hungarica

Volumn 100, Issue 4, 2013, Pages 478-488

  Almasi A ^a   Bojcsev, Sz ^b   Fischer, T ^b   Simon, H ^b   Perjesi P ^a   Fischer, Emil ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

drug excretion; liver; metabolic enzymes; p nitrophenol; rat; small intestine

Indexed keywords

4 NITROPHENOL; ARYLSULFATASE; BETA GLUCURONIDASE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; SULFOTRANSFERASE; 4-NITROPHENOL; GLUCURONIC ACID; NITROPHENOL; P-NITROPHENOL GLUCURONIDE; SULFATE;

ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONCENTRATION (PARAMETERS); DRUG EXCRETION; ENZYME ACTIVITY; JEJUNUM; LIVER; NONHUMAN; RAT; SMALL INTESTINE; ANIMAL; BILE; DRUG INACTIVATION; ENZYME ACTIVATION; ENZYMOLOGY; HEPATOBILIARY SYSTEM; MALE; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ARYLSULFATASES; BILE; BILIARY TRACT; ENZYME ACTIVATION; GLUCURONATES; GLUCURONIC ACID; GLUCURONIDASE; GLUCURONOSYLTRANSFERASE; INACTIVATION, METABOLIC; JEJUNUM; LIVER; MALE; NITROPHENOLS; RATS; RATS, WISTAR; SULFATES; SULFOTRANSFERASES;

EID: 84890334672     PISSN: 0231424X     EISSN: 15882683     Source Type: Journal    
DOI: 10.1556/APhysiol.100.2013.015     Document Type: Article

References (35)

1. Almási A, Fischer E, Perjési P: A simple and rapid ion-pair HPLC method for simultaneous quantitation of 4-nitrophenol and its glucuronide and sulfate conjugates. J. Biochem. Biophys. Methods 69, 43-50 (2006)
2. Almási A, Fischer E, Perjési P: Isocratic ion-pair HPLC method for quantitation of 4-nitrophenol and it's conjugated metabolites from bile. Sci. Pharm. 79, 837-847 (2011)
3. Ayrton A, Morgan P: Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31, 469-497 (2001)
4. Baldwin MK, Selby MA, Bloomberg H: Measurement of phenol in urine by the method of van Haaften and Sie: a critical appraisal. Analyst, 106, 763-767 (1981)
5. Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB: Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence and kinetic properties. J. Lipid Res. 30, 429-440 (1989)
6. Beaumont K (2004): The importance of gut wall metabolism in determining drug bioavailibility. In: Drug Bioavailibility: Estimation of Solubility, Permeability, Absorption and Bioavailibility, eds van de Waterbeemd, Lenneraus H, Artursson P, Willey-VCH Verlag GmbH and Co. KgaA, Weinheim, FRG, Ch. 13, pp. 311-328
7. Capiello M, Franchi M, Giuliani L, Pacifici GM: Distribution of 2-naphthol sulfotransferase and its substrate adenosine 3-phosphate 5-phosphosulfate in human tissues. Eur. J. Clin. Pharmacol. 37, 317.320 (1989)
8. Capiello M, Giuliani L, Pacifici GM: Distribution of UDP- glucuronyltransferase and its endogenous substrate uridine 5-diphosphoglucuronic acid in human tissues. Eur. J. Pharmacol. 41, 345.350 (1991)
9. Chen G, Battaglia E, Senay C, Falany CN, Radominska-Pandya A: Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase (SULT1A1): 7-Azido-4-methylcoumarin. Protein Sci. 8, 2151. 2157 (1999)
10. Danovitch SH, Laster R: The development of arylsulfatase in the small intestine of the rat. Biochem. J. 114, 343-350 (1969)
11. Eadsforth CV, Coveney DC: Measurement of phenol in urine using a high-performance liquid chromatographic method. Analyst 109, 175-176 (1984)
12. Falany CN: Molecular enzymology of human cytosolic sulfortransferases. Trends Pharmacol. Sci. 12, 255-259 (1991)
13. Fischer E, Rafiei A, Bojcsev S: Intestinal elimination of p-nitrophenol in the rat. Acta Physiol. Hung. 83, 355-362 (1995)
14. Fishman WH. (1974): ß-Glucuronidase. In: Methods of Enzymatic Analysis, ed Bergmeyer HU, Academic Press, New York, pp. 929-943
15. George CF: Drug metabolism by gastrointestinal mucosa. Clin. Pharmacokinet. 6, 259-274 (1981)
16. Hartiala KJW: Metabolism of hormones, drugs and other substances by the gut. Physiol. Rev. 53, 496-534 (1973)
17. Hänninen O, Lindström-Seppä P, Pelkonen K: Role of the gut in xenobiotic metabolism. Arch. Toxicol. 60, 34-36 (1987)
18. Inoue H, Yokota H, Taniyama H, Kuwahara H, Ogawa H, Kato S, Yuasa A: 1-Naphthol-ß-o-glucuronides formed intraluminally in rat small intestine mucosa and absorbed into the colon. Life Sci. 65, 1579-1588 (1999)
19. Koster AS, Noordhoek J: Glucuronidation in the rat intestinal wall. Comparison of isolated mucosal cells, latent microsomes and activated microsomes. Biochem. Pharmacol. 32, 895-900 (1983)
20. Kothare AP, Zimmerman CL: Intestinal metabolism: The role of enzyme localization in phenol metabolite kinetics. Drug Metab. Dispos. 30, 586-594 (2002)
21. Kuhn MD, Rost M, Müller D: Para-nitrophenol glucuronidation and sulphatation in rat and human slices. Exp. Toxic. Pathol. 53, 81-87 (2001)
22. Laitinen M, Watkins JB (1986): Mucosal biotransformations. In: Gastrointestinal Toxicology, eds Rozman K, Hänninen O Elsevier Press, Amsterdam, pp. 169-192
23. Linn LH, Chiba M, Baillie TA: Is the role of the small intestine in first-pass metabolism overemphasized? Pharm. Rev. 51, 135-157 (1999)
24. Liu H, Wu B, Pan G, He L, Li Z, Fan M, Jian L, Chen M, Wang K, Huang C: Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats. Drug Metab. Dispos. 40, 2109-2118 (2012)
25. Maiti S, Grant S, Baker SM, Karanth S, Pope CN, Chen G: Stress regulation of sulfotransferases in male rat liver. Biochem. Biophys. Res. Commun. 323, 235-241 (2004)
26. Mojarrabi B, Mackenzie PI: Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon. Biochem. Biophys. Res. Commun. 247, 704-709 (1998)
27. Pang KS, Maeng HJ, Fan J: Interplay of transporters and enzymes in drug and metabolite processing. Mol. Pharm. 6, 1734-1755 (2009)
28. Preuksaritonont T, Gorham LM, Hochman JH, Tran LO, Vyas KP: Comparative studies of drug metabolising enzymes in dog, monkey and human small intestines and in Caco-2-cells. Drug Metab. Disp. 24, 634-642 (1996)
29. Rafiei A, Bojcsev S, Fischer E: Dose-dependent intestinal and hepatic glucuronidation and sulfatation of p-nitrophenol in the rat. Acta Physiol. Hung. 84, 333-335 (1996)
30. Schwenk M: Glucuronidation and sulphatation in gastrointestinal tract. Progr. Pharmacol. Clin. Pharmacol. 7, 155-169 (1989)
31. Shiratani H, Katoh M, Nakijama M, Yokoi T: Species differences in UDP-glucuronyltransferase activities in mice and rats. Drug Metab. Disp. 36, 1745-1752 (2008)
32. Teubner W, Meinl W, Florian S, Kretzschmar M, Glatt H: Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem. J. 404, 207-215 (2007)
33. Tukey RH, Strassburg CP: Human UDP-glucuronosyltransferases: metabolism, expression and disease. Ann. Rev. Pharmacol. Toxicol. 40, 581-616 (2000)
34. van Norman KH: The biuret reaction and the cold nitric acid test in the recognition of protein. Biochem. J. 4, 127-135 (1909)
35. Wu B, Kulkarni K, Basu S, Zhang S, Hu M: First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J. Pharm. Sci. 100, 3655-3681 (2011)