Dose-dependent intestinal and hepatic glucuronidation and sulfatation of p-nitrophenol in the rat

Acta Physiologica Hungarica

Volumn 84, Issue 3, 1996, Pages 333-335

  Rafiei, A ^a   Bojcsev, S ^a   Fischer, E ^a,b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Glucuronidation; P nitrophenol; Rat; Sulfatation

Indexed keywords

4 NITROPHENOL; 4-NITROPHENOL; GLUCURONIC ACID; NITROPHENOL; SULFATE;

ANIMAL; ARTICLE; BILE; DOSE RESPONSE; JEJUNUM; LIVER; MALE; METABOLISM; OSMOLARITY; RAT; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; BILE; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCURONATES; JEJUNUM; LIVER; MALE; NITROPHENOLS; OSMOLAR CONCENTRATION; RATS; RATS, WISTAR; SULFATES;

EID: 0030322926     PISSN: 0231424X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Fischer, E., Lauterbach, F.: Intestinal metabolism and metabolite transport of p-nitrophenol in the guinea pig in vivo after luminal and blood side administration Z. Gastroenterol, 30, 224 (1992)
2. George, C. F.: Drug metabolism by gastrointestinal mucosa. Clin. Pharmacokinet. 6, 259-271 (1981)
3. Goon, D., Klaassen, C. D.: Dose-dependent intestinal glucuronidation and sulfatation of acetaminophen in the rat in situ. J. Pharm. Exp. Ther. 252, 201-207 (1990)
4. Hänninen, O., Lindström-Seppä, P., Pelkonen, K.: Role of gut in xenobiotic metabolism. Arch. Toxicol. 60, 34-36 (1987)
5. Lauterbach, F., Schorn, M., Sprakties, G., Sund, R. B.: Compartmentalization of intestinal conjugation reactions and conjugate transport: studies with phenols and p-aminobenzoic acid Progr. in Pharmacol. and Clin. Pharmacol. 712, 231-242 (1982)
6. Schwenk, M.: Glucuronidation and sulfatation in the gastrointestinal tract Progr. in Pharmacol. 712, 155-169 (1989)