MicroRNA-142-3p inhibits cell proliferation in human acute lymphoblastic leukemia by targeting the MLL-AF4 oncogene

Molecular Biology Reports

Volumn 40, Issue 12, 2013, Pages 6811-6819

  Dou, Liping ^a   Li, Jingxin ^a   Zheng, Dehua ^b   Li, Yonghui ^a   Gao, Xiaoning ^a   Xu, Chengwang ^a   Gao, Li ^a   Wang, Lili ^a   Yu, Li ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b 309TH HOSPITAL OF PLA   (China)

Author keywords

Acute lymphoblastic leukemia; MicroRNA; miR 142 3p; MLL AF4

Indexed keywords

HYBRID PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 142 3P; MIXED LINEAGE LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR HOXA9; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TARGETING; FEMALE; FUSION GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TARGETING; HOXA10 GENE; HOXA7 GENE; HOXA9 GENE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALE; MIDDLE AGED; MLL AF4 GENE; ONCOGENE; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; ONCOGENES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROMOTER REGIONS, GENETIC; YOUNG ADULT;

EID: 84890329596     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2798-6     Document Type: Article

References (18)

1. Dou L, Zheng D, Li J, Li Y, Gao L, Wang L, Yu L (2012) Methylation mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression. Oncogene 31:507-517
2. Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O (2005) Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood 106:3559-3566
3. Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228-234
4. Coskuna E, von der Heidea EK, Schleea C, Kühnla A, Gbugetb N, Hoelzerb D, Hofmannc WK, Thiela E, Baldusa CD (2011) The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia. Leuk Res 35:208-213
5. Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Gel C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X (2010) Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol 12:390-399
6. Li Y, Guessous F, Zhang Y, DiPierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B, Abounader R (2009) MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69:7569-7576
7. Lopez-Serra P, Esteller M (2012) DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene 31:1609-1622
8. Kotani A, Ha D, Hsieh J, Rao PK, Schotte D, den Boer ML, Armstrong SA, Lodish HF (2009) miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. Blood 114:4169-4178
9. Kotani A, Ha D, Schotte D, den Boer ML, Armstrong SA, Lodish HF (2010) A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. Cell Cycle 9:1037-1042
10. Wang XS, Gong JN, Yu J, Wang F, Zhang XH, Yin XL, Tan ZQ, Luo ZM, Yang GH, Shen C, Zhang JW (2012) MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood 119:4992-5004
11. REG cells by targeting AC9 mRNA. EMBO Rep 10:180-185
12. Lv M, Zhang X, Jia H, Li D, Zhang B, Zhang H, Hong M, Jiang T, Jiang Q, Lu J, Huang X, Huang B (2012) An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways. Leukemia 26:769-777
13. Lin RJ, Xiao DW, Liao LD, Chen T, Xie ZF, Huang WZ, Wang WS, Jiang TF, Wu BL, Li EM, Xu LY (2012) MiR-142-3p as a potential prognostic biomarker for esophageal squamous cell carcinoma. J Surg Oncol 105:165-182
14. Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S, Cole CN (2007) Altered microRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res 67:11612-11620
15. Chen A, Luo M, Yuan G, Yu J, Deng T, Zhang L, Zhou Y, Mitchelson K, Cheng J (2008) Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells. Biotechnol Lett 30:2045-2052
16. Merkerova M, Belickova M, Bruchova H (2008) Differential expression of microRNAs in hematopoietic cell lineages. Eur J Haematol 81:304-310
17. Ju X, Li X, Shi Q, Hou H, Sun N, Shen B (2009) Differential microRNA expression in childhood B-cell precursor acute lymphoblastic leukemia. Pediatr Hematol Oncol 26:1-10
18. Kim D, Song J, Kim S, Kang SS, Jin EJ (2011) MicroRNA-142-3p regulates TGF-b3-mediated region-dependent chondrogenesis by regulating ADAM9. Biochem Biophys Res Commun 414:653-659