MicroRNA-125b inhibitor sensitizes human primary glioblastoma cells to chemotherapeutic drug temozolomide on invasion

In Vitro Cellular and Developmental Biology - Animal

Volumn 49, Issue 8, 2013, Pages 599-607

  Wan, Yi ^a   Sun, Guan ^b   Zhang, Shuguang ^c   Wang, Zhimin ^a   Shi, Lei ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANTONG UNIVERSITY   (China)

^c JIANGSU UNIVERSITY   (China)

Author keywords

Invasion; MicroRNA; Temozolomide

Indexed keywords

DACARBAZINE; DRUG DERIVATIVE; MICRORNA; MIRN125 MICRORNA, HUMAN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; TEMOZOLOMIDE;

ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; GLIOBLASTOMA; HUMAN; IN VITRO STUDY; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; DACARBAZINE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; RECEPTOR, NOTCH1;

EID: 84890316990     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-013-9644-y     Document Type: Article

References (33)

1. Athanassiou H.; Synodinou M.; Maragoudakis E.; Paraskevaidis M.; Verigos C.; Misailidou D.; Antonadou D.; Saris G.; Beroukas K.; Karageorgis P. Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J. Clin. Oncol. 23: 2372-2377; 2005.
2. Bin Hafeez B.; Adhami V. M.; Asim M.; Siddiqui I. A.; Bhat K. M.; Zhong W.; Saleem M.; Din M.; Setaluri V.; Mukhtar H. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin. Cancer Res. 15: 452-459; 2009.
3. Cairo S.; Wang Y.; de Reyniès A.; Duroure K.; Dahan J.; Redon M.-J.; Fabre M.; McClelland M.; Wang X. W.; Croce C. M.; Buendia M.-A. Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. PNAS 107: 20471-20476; 2010.
4. Chan J. A.; Krichevsky A. M.; Kosik K. S. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65: 6029-6033; 2005.
5. Clarke M. J.; Mulligan E. A.; Grogan P. T.; Mladek A. C.; Carlson B. L.; Schroeder M. A.; Curtin N. J.; Lou Z.; Decker P. A.; Wu W.; Plummer E. R.; Sarkaria J. N. Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol. Cancer Ther. 8: 407-414; 2009.
6. Darling J. L. The in vitro biology of human brain tumors, p. 1-25. In: Thomas D. G. T. (ed) Neuro-oncology: primary malignant brain tumors. Johns Hopkins University Press, Baltimore; 1990.
7. Gilbert C. A.; Daou M.; Moser R. P.; Ross A. H. Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res. 70: 6870-6879; 2010.
8. Guo J.; He L.; Yuan P.; Wang P.; Lu Y.; Tong F.; Wang Y.; Yin Y.; Tian J.; Sun J. ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway. Oncol. Rep. 28(5): 1709-1718; 2012.
9. Hirose Y.; Berger M. S.; Pieper R. O. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res. 61: 1957-1963; 2001.
10. Jiang L.; Wu J.; Chen Q.; Hu X.; Li W.; Hu G. Notch1 expression is upregulated in glioma and is associated with tumor progression. J. Clin. Neurosci. 18(3): 387-390; 2011.
11. Johnson C. D.; Esquela-Kerscher A.; Stefani G.; Byrom M.; Kelnar K.; Ovcharenko D.; Wilson M.; Wang X.; Shelton J.; Shingara J.; Chin L.; Brown D.; Slack F. J. The let-7 microrna represses cell proliferation pathways in human cells. Cancer Res. 67: 7713-7722; 2007.
12. Kim J. T.; Kim J. S.; Ko K. W. et al. Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas. Oncol. Rep. 16: 33-39; 2006.
13. Li J.; Cui Y.; Gao G.; Zhao Z.; Zhang H.; Wang X. Notch1 is an independent prognostic factor for patients with glioma. J. Surg. Oncol. 103(8): 813-817; 2011.
14. Livak K. J.; Schmittgen T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) Method. Methods 25: 402-408; 2001.
15. Mei J.; Bachoo R.; Zhang C.-L. MicroRNA-146a inhibits glioma development by targeting Notch1. Mol. Cell Biol. 31: 3584-3592; 2011.
16. Pang R. T. K.; Leung C. O. N.; Ye T.-M.; Liu W.; Chiu P. C. N.; Lam K. K. W.; Lee K.-F.; Yeung W. S. B. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 31: 1037-1044; 2010.
17. Ren Y.; Kang C. S.; Yuan X. B.; Zhou X.; Xu P.; Han L.; Wang G. X.; Jia Z.; Zhong Y.; Yu S.; Sheng J.; Pu P. Y. Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro. J. Biomater. Sci. Polym. Ed. 21: 303-314; 2010.
18. Shi L.; Wan Y.; Sun G.; Gu X.; Qian C.; Yan W.; Zhang S.; Pan T.; Wang Z.; You Y. Functional differences of miR-125b on the invasion of primary glioblastoma CD133-negative cells and CD133-positive cells. Neuromolecular Med. 14(4): 303-316; 2012b.
19. Shi L.; Zhang J.; Pan T.; Zhou J. et al. MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation. Brain Res. 1312: 120-126; 2010.
20. Shi L.; Zhang S.; Feng K.; Wu F.; Wan Y.; Wang Z.; Zhang J.; Wang Y.; Yan W.; Fu Z.; You Y. MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis. Int. J. Oncol. 40(1): 119-129; 2012a.
21. Stupp R.; Tonn J. C.; Brada M.; Pentheroudakis G. High-grade malignant glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 21: v190-v193; 2010.
22. Tan G.; Niu J.; Shi Y.; Ouyang H.; Wu Z. NF-B-dependent MicroRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiation. J. Biol. Chem. 287: 33036-33047; 2012.
23. Vescovi A. L.; Galli R.; Reynolds B. A. Brain tumour stem cells. Nat. Rev. Cancer 6: 425-436; 2006.
24. Wan Y.; Fei X. F.; Wang Z. M.; Jiang D. Y.; Chen H. C.; Yang J.; Shi L.; Huang Q. Expression of miR-125b in the new, highly invasive glioma stem cell and progenitor cell line SU3. Chin. J. Cancer 31(4): 207-214; 2012.
25. Wick W.; Wick A.; Schulz J. B.; Dichgans J.; Rodemann H. P.; Weller M. Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase1. Cancer Res. 62: 1915-1919; 2002.
26. Xia H. F.; He T. Z.; Liu C. M. et al. MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf. Cell. Physiol. Biochem. 23: 347-358; 2009.
27. Xu N.; Zhang L.; Meisgen F.; Harada M.; Heilborn J.; Homey B.; Grandér D.; Ståhle M.; Sonkoly E.; Pivarcsi A. MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion. J. Biol. Chem. 287: 29899-29908; 2012.
28. Yu B.; Wei J.; Qian X.; Lei D.; Ma Q.; Liu Y. Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma. Oncol. Rep. 27(2): 547-552; 2012.
29. Zhang C.; Yao Z.; Zhu M.; Ma X.; Shi T.; Li H.; Wang B.; Ouyang J.; Zhang X. Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting Notch1. J. Huazhong Univ. Sci. Technolog. Med. Sci. 32(3): 375-382; 2012c.
30. Zhang D.; Jing Z.; Qiu B.; Wu A.; Wang Y. Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2. Oncol. Rep. 26(4): 901-908; 2011a.
31. Zhang S.; Wan Y.; Pan T.; Gu X.; Qian C.; Sun G.; Sun L.; Xiang Y.; Wang Z.; Shi L. MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide. J. Mol. Neurosci. 47(2): 346-356; 2012a.
32. Zhang X.; Chen T.; Zhang J.; Mao Q.; Li S.; Xiong W.; Qiu Y.; Xie Q.; Ge J. Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation. Cancer Sci. 103(2): 181-190; 2012b.
33. Zhang Y.; Yan L.; Wu Q.; Du Z.; Chen J.; Liao D.; Huang M.; Hou J.; Wu Q.; Zeng M.; Huang W.; Zeng Y.; Shao J. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res. 71: 3552-3562; 2011b.