Metabolism of mequindox and its metabolites identification in chickens using LC-LTQ-Orbitrap mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 881-882, Issue , 2012, Pages 96-106

  Shan, Qi ^a   Liu, Yiming ^a,b   He, Limin ^a   Ding, Huanzhong ^a   Huang, Xianhui ^a   Yang, Fan ^a   Li, Yafei ^a   Zeng, Zhenling ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Chicken; LC LTQ Orbitrap; Mequindox; Metabolism; Metabolites

Indexed keywords

CARBONYL REDUCTION; CHICKEN; CHICKEN PLASMA; DEACETYLATION; FEED ADDITIVES; IN-VITRO; IN-VIVO; LC-LTQ-ORBITRAP; MEQUINDOX; METABOLIC PATHWAYS; ORBITRAP; QUADRUPOLES;

ACETYLATION; ANIMALS; BIOMOLECULES; ELECTROSPRAY IONIZATION; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHYSIOLOGY; TISSUE; VETERINARY MEDICINE;

METABOLISM;

DRUG METABOLITE; MEQUINDOX; QUINOXALINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; CHICKEN; DEACETYLATION; DRUG METABOLISM; ELECTROSPRAY; FECES; FEMALE; HYDROXYLATION; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MICROSOME; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BILE; CHICKENS; CHROMATOGRAPHY, LIQUID; FECES; FEMALE; MALE; METABOLOME; QUINOXALINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TISSUE DISTRIBUTION; VETERINARY DRUGS;

GALLUS GALLUS;

EID: 84855350761     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.008     Document Type: Article

References (15)

1. Yuan Z.H. Veterinary Medicine Guide 1998, China Agricultural Press, Beijing, China. 1st ed.
2. Chen Z.L. Veterinary Pharmacology 2006, China Agricultural Press, Beijing, China. 3rd ed.
3. Zhang X.Y., Li Y.Q., Xie W.Y., Tian Z.H., Hao C.J. Afr. J. Biotechnol. 2010, 9:8472.
4. Huang X.J., Ihsan A., Wang X., Dai M.H., Wang Y.L., Su S.J., Xue X.J., Yuan Z.H. Toxicol. Lett. 2009, 191:167.
5. Ihsan A., Wang X., Liu Z., Wang Y., Huang X., Liu Y., Yu H., Zhang H., Li T., Yang C., Yuan Z. Toxicol. Appl. Pharmacol. 2011, 252:281.
6. Yuan Z.H., Huang X.J., Wang X., Ihsan A., Liu Q., Xue X.J., Su S.J., Yang C.H., Zhou W. Toxicol. Lett. 2010, 198:112.
7. Yuan Z.H., Liu Z.Y., Huang L.L., Chen D.M. Rapid. Commun. Mass Spectrom. 2010, 24:909.
8. Zeng Z.L., Liu Y.C., Si H.B., He L.M., Ding H.Z., Huang X.H., Chen J.X., Chen Z.L. Chin. J. Anal. Chem. 2010, 38:82.
9. Herebian D., Lamshoft M., Mayatepek E., Spiekerkoetter U. Rapid. Commun. Mass Spectrom. 2010, 24:791.
10. Kalgutkar A.S., Peterman S.M., Duczak N., Lame M.E., Soglia J.R. J. Am. Soc. Mass Spectrom. 2006, 17:363.
11. Lim H.K., Chen J., Sensenhauser C., Cook K., Subrahmanyam V. Rapid. Commun. Mass Spectrom. 2007, 21:1821.
12. Makarov A., Denisov E., Kholomeev A., Baischun W., Lange O., Strupat K., Horning S. Anal. Chem. 2006, 78:2113.
13. Dunn W.B., Broadhurst D., Brown M., Baker P.N., Redman C.W.G., Kenny L.C., Kell D.B. J. Chromatogr. B 2008, 871:288.
14. Xiao X.L., Bi Y.F., Wang X., Xu S.X., Sun L., Zhang L., Zhong F., Wang S.H., Ding S.Y. Rapid. Commun. Mass Spectrom. 2011, 25:889.
15. Zhang S.X., Shen J.Z., Yang C.Y., Wu C.M., Feng P.S., Wang Z.H., Li Y., Li Y.S. Rapid. Commun. Mass Spectrom. 2010, 24:375.