Poly-proline motif in HIV-2 Vpx is critical for its efficient translation

Journal of General Virology

Volumn 95, Issue PART 1, 2014, Pages 179-189

  Miyake, Ariko ^a   Fujita, Mikako ^b   Fujino, Haruna ^b   Koga, Ryoko ^b   Kawamura, Sogo ^b   Otsuka, Masami ^b   Ode, Hirotaka ^c,d   Iwatani, Yasumasa ^c   Sakai, Yosuke ^a   Doi, Naoya ^a,d   Nomaguchi, Masako ^a   Adachi, Akio ^a   Miyazaki, Yasuyuki ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^d The Japan Foundation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROLINE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VPR PROTEIN; VPX PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; IN VIVO STUDY; MUTATIONAL ANALYSIS; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY; RNA TRANSLATION; SIMIAN IMMUNODEFICIENCY VIRUS; VIROGENESIS; VIRUS REPLICATION;

EID: 84890275460     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.057364-0     Document Type: Article

References (32)

1. Accola, M. A., Bukovsky, A. A., Jones, M. S. & Göttlinger, H. G. (1999). A conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm). J Virol 73, 9992-9999.
2. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A. & Martin, M. A. (1986). Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59, 284-291.
3. Anraku, K., Fukuda, R., Takamune, N., Misumi, S., Okamoto, Y., Otsuka, M. & Fujita, M. (2010). Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry 49, 5109-5116.
4. Berger, G., Durand, S., Fargier, G., Nguyen, X.-N., Cordeil, S., Bouaziz, S., Muriaux, D., Darlix, J.-L. & Cimarelli, A. (2011). APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. PLoS Pathog 7, e1002221.
5. Blanco-Melo, D., Venkatesh, S. & Bieniasz, P. D. (2012). Intrinsic cellular defenses against human immunodeficiency viruses. Immunity 37, 399-411.
6. Doerfel, L. K., Wohlgemuth, I., Kothe, C., Peske, F., Urlaub, H. & Rodnina, M. V. (2013). EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science 339, 85-88.
7. Fujita, M., Otsuka, M., Miyoshi, M., Khamsri, B., Nomaguchi, M. & Adachi, A. (2008a). Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages. J Virol 82, 7752-7756.
8. Fujita, M., Otsuka, M., Nomaguchi, M. & Adachi, A. (2008b). Functional region mapping of HIV-2 Vpx protein. Microbes Infect 10, 1387-1392.
9. Fujita, M., Otsuka, M., Nomaguchi, M. & Adachi, A. (2010). Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions. Rev Med Virol 20, 68-76.
10. Goujon, C., Arfi, V., Pertel, T., Luban, J., Lienard, J., Rigal, D., Darlix, J.-L. & Cimarelli, A. (2008). Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. J Virol 82, 12335-12345.
11. Gramberg, T., Sunseri, N. & Landau, N. R. (2010). Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx. J Virol 84, 1387-1396.
12. Gutierrez, E., Shin, B.-S., Woolstenhulme, C. J., Kim, J.-R., Saini, P., Buskirk, A. R. & Dever, T. E. (2013). eIF5A promotes translation of polyproline motifs. Mol Cell 51, 35-45.
13. Harris, R. S., Hultquist, J. F. & Evans, D. T. (2012). The restriction factors of human immunodeficiency virus. J Biol Chem 287, 40875-40883.
14. Hrecka, K., Hao, C., Gierszewska, M., Swanson, S. K., Kesik-Brodacka, M., Srivastava, S., Florens, L., Washburn, M. P. & Skowronski, J. (2011). Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474, 658-661.
15. Jeanmougin, F., Thompson, J. D., Gouy, M., Higgins, D. G. & Gibson, T. J. (1998). Multiple sequence alignment with CLUSTAL_X. Trends Biochem Sci 23, 403-405.
16. Jin, L., Zhou, Y. & Ratner, L. (2001). HIV type 2 Vpx interaction with Gag and incorporation into virus-like particles. AIDS Res Hum Retroviruses 17, 105-111.
17. Kawamura, M., Sakai, H. & Adachi, A. (1994). Human immunodeficiency virus Vpx is required for the early phase of replication in peripheral blood mononuclear cells. Microbiol Immunol 38, 871-878.
18. Khamsri, B., Murao, F., Yoshida, A., Sakurai, A., Uchiyama, T., Shirai, H., Matsuo, Y., Fujita, M. & Adachi, A. (2006). Comparative study on the structure and cytopathogenic activity of HIV Vpr/Vpx proteins. Microbes Infect 8, 10-15.
19. Laguette, N., Sobhian, B., Casartelli, N., Ringeard, M., Chable-Bessia, C., Ségéral, E., Yatim, A., Emiliani, S., Schwartz, O. & Benkirane, M. (2011). SAMHD1 is the dendritic-and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474, 654-657.
20. Lebkowski, J. S., Clancy, S. & Calos, M. P. (1985). Simian virus 40 replication in adenovirus-transformed human cells antagonizes gene expression. Nature 317, 169-171.
21. Mahnke, L. A., Belshan, M. & Ratner, L. (2006). Analysis of HIV-2 Vpx by modeling and insertional mutagenesis. Virology 348, 165-174.
22. Malim, M. H. & Bieniasz, P. D. (2012). HIV restriction factors and mechanisms of evasion. Cold Spring Harb Perspect Med 2, a006940.
23. Page, R. D. (1996). TreeView: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12, 357-358.
24. Pancio, H. A. & Ratner, L. (1998). Human immunodeficiency virus type 2 Vpx-Gag interaction. J Virol 72, 5271-5275.
25. Park, I.-W. & Sodroski, J. (1995). Amino acid sequence requirements for the incorporation of the Vpx protein of simian immunodeficiency virus into virion particles. J Acquir Immune Defic Syndr Hum Retrovirol 10, 506-510.
26. Sharp, P. M., Bailes, E., Stevenson, M., Emerman, M. & Hahn, B. H. (1996). Gene acquisition in HIV and SIV. Nature 383, 586-587.
27. Shibata, R., Kawamura, M., Sakai, H., Hayami, M., Ishimoto, A. & Adachi, A. (1991). Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J Virol 65, 3514-3520.
28. Singh, S. P., Lai, D., Cartas, M., Serio, D., Murali, R., Kalyanaraman, V. S. & Srinivasan, A. (2000). Epitope-tagging approach to determine the stoichiometry of the structural and nonstructural proteins in the virus particles: amount of Vpr in relation to Gag in HIV-1. Virology 268, 364-371.
29. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F. & Higgins, D. G. (1997). The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25, 4876-4882.
30. Ude, S., Lassak, J., Starosta, A. L., Kraxenberger, T., Wilson, D. N. & Jung, K. (2013). Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches. Science 339, 82-85.
31. Ueno, F., Shiota, H., Miyaura, M., Yoshida, A., Sakurai, A., Tatsuki, J., Koyama, A. H., Akari, H., Adachi, A. & Fujita, M. (2003). Vpx and Vpr proteins of HIV-2 up-regulate the viral infectivity by a distinct mechanism in lymphocytic cells. Microbes Infect 5, 387-395.
32. Zheng, Y.-H., Jeang, K.-T. & Tokunaga, K. (2012). Host restriction factors in retroviral infection: promises in virus-host interaction. Retrovirology 9, 112.