Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis

Neuroscience

Volumn 258, Issue , 2014, Pages 111-120

  Alvarez, P ^a,b   Bogen, O ^a,b   Chen, X ^a,b   Giudice, L C ^a,b   Levine, J D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chronic pelvic pain; Endometriosis; Leptin; Mechanical hyperalgesia; Nociceptor; Ob gene

Indexed keywords

ANALGESIC AGENT; ESTRADIOL; ESTROGEN; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTAGONIST; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PEGYLATED LEPTIN ANTAGONIST; RECOMBINANT LEPTIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOMETRIOSIS; ENDOMETRIUM; ESTROGEN BLOOD LEVEL; ESTROGEN SYNTHESIS; FEMALE; GASTROCNEMIUS MUSCLE; HYPERALGESIA; MECHANICAL HYPERALGESIA; MECHANICAL STIMULATION; NOCICEPTION; NONHUMAN; OVARIECTOMY; PAIN; PAIN RECEPTOR; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; UPREGULATION;

BOVINE SERUM ALBUMIN; BSA; CHRONIC PELVIC PAIN; D-PBS; DORSAL ROOT GANGLION; DRG; DULBECCO'S PHOSPHATE-BUFFERED SALINE; ENDOMETRIOSIS; JAK2; JANUS KINASE2; LEPTIN; LEPTIN RECEPTOR; MECHANICAL HYPERALGESIA; NOCICEPTOR; OB GENE; OB-R; RECOMBINANT RAT LEPTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RRLEPTIN; RT-PCR; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3; STAT3;

ANIMALS; CHRONIC PAIN; DISEASE MODELS, ANIMAL; ENDOMETRIOSIS; ENDOMETRIUM; ENZYME INHIBITORS; ESTRADIOL; ESTROGENS; FEMALE; HYPERALGESIA; JANUS KINASE 2; LEPTIN; MUSCLE, SKELETAL; NOCICEPTORS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; RNA, MESSENGER; TOUCH; UTERUS;

EID: 84890234087     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.11.008     Document Type: Article

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