Leptin enhances NMDA-induced spinal excitation in rats: A functional link between adipocytokine and neuropathic pain

Pain

Volumn 152, Issue 6, 2011, Pages 1263-1271

  Tian, Yinghong ^a,b   Wang, Shuxing ^a   Ma, Yuxin ^a   Lim, Grewo ^a   Kim, Hyangin ^a   Mao, Jianren ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Allodynia; Hyperalgesia; JAK2 STAT3; Leptin; Neuropathic pain; NMDA receptor; Patch clamp recording

Indexed keywords

ADIPOCYTOKINE; DIZOCILPINE; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; STAT3 PROTEIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HYPERALGESIA; MALE; MOUSE; NERVE EXCITABILITY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TISSUE SLICE; UPREGULATION; WHOLE CELL;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DIZOCILPINE MALEATE; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HYPERALGESIA; LEPTIN; MALE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; N-METHYLASPARTATE; NEURALGIA; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; RECEPTORS, N-METHYL-D-ASPARTATE; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; SPINAL CORD; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 79956065269     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.01.054     Document Type: Article

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