Riot Control Agents in Military Operations, Civil Disturbance Control and Potential Terrorist Activities, with Particular Reference to Peripheral Chemosensory Irritants

Chemical Warfare Agents: Toxicology and Treatment, Second Edition

Volumn , Issue , 2007, Pages 543-612

  Ballantyne, Bryan ^a  

^a NONE   (United States)

Author keywords

Aerosolization by thermal volatilization; Chemical agent use in peacekeeping operations; Metabolism and toxicokinetics; Peripheral chemosensory irritant (PCSI) chemicals; Riot control agents (RCAs)

Indexed keywords

EID: 84890180569     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470060032.ch26     Document Type: Chapter

References (355)

1. Aalphen CCK-v, Visset R, van der Linden JE et al. (1985). Protection of the police against tear gas with soft lenses. Mil Med, 150, 451-454.
2. ACGIH (2006). 2006 TLVsr® and BEIsr®. Cincinnati, OH, USA: American Conference of Governmental Industrial Hygienists.
3. Adams JP, Fee N and Kenmore PI (1966). Tear gas injuries. J Bone Joint Surg 48A, 436-442.
4. Akagi A, Sano N, Uehara H et al. (1998). Noncarcinogenicity of capsaicinoids in B6C3F1 mice. Food Chem Toxicol, 31, 1065-1071.
5. Allinson G and McLeod CW (1997a). Characterization of lachrymators by ambient temperature ion mobility spectrometry. J Forens Sci, 42, 312-315.
6. Allinson G and McLeod CW (1997b). Characterization of tear gas residues by ion mobility spectrometry. Appl Spectrom, 51, 1880-1889.
7. Allinson G, Saul C, McLeod CW et al. (1998). Identification of tear gases in suspect spray cans and cloth samples by ion mobility spectrometry. J Forens Sci, 43, 845-849.
8. Anderson D and Conning DM (1993). Experimental Toxicology, Second Edition. Cambridge, UK: Royal Society of Chemistry.
9. Anderson PJ, Lau GSN, Taylor WRJ et al. (1996). Acute effects of the potent lacrimator o-chlorobenzylidene malononitrile (CS) tear gas. Human Exp Toxicol, 15, 461-465.
10. Arceo SDB, Madrigal-Bujaidor E, Montellano EC et al. (1995). Genotoxic effects produced by capsaicin in mouse during subchronic treatment. Mut Res, 345, 105-109.
11. Ashton I, Cotes JE and Holland P (1977). Acute effect of dibenz(b.f)-1,4-oxazepine aerosol upon lung function of healthy young men. J Physiol London 275, 85P.
12. Ayers KM and Stahl CJ (1972). Ballistic characteristics of wounding effects of tear gas gun loaded with ortho-chlorobenzalmalononitrile. J Forens Sci, 17, 292-297.
13. Azizan A and Blevins RD (1995). Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay. Arch Environ Contamin Toxicol, 28, 248-258.
14. Baker DJ (1999). The pre-hospital management of injury following mass toxic release: a comparison of military and civil approaches. Resuscitation, 42, 155-159.
15. Baker D (2004). Civilian exposure to toxic agents: emergency medical response. Prehosp Disast Med, 19, 174-178.
16. Ballantyne B (1977a). Riot control agents. Biomedical and health aspects of the use of chemicals in civil disturbances. In: Medical Annual, (RB. Scott and J Frazer eds.) 1977, pp. 7-41. Bristol, UK: Wright.
17. Ballantyne B (1977b). The acute mammalian toxicology of dibenz(b.f)-1,4-oxazepine. Toxicology, 8, 347-379.
18. Ballantyne B. (1979). Evaluation of ophthalmic hazards from an aerosol generator of ochlorobenzylidene malononitrile (CS). Mil Med, 144, 691-694.
19. Ballantyne B (1982). Dosage levels associated with the induction of respiratory tract inflammation by acute exposure to titanium tetrachloride smokes. Toxicologist, 2, 45.
20. Ballantyne B (1983). The cyanogenic potential of 2-chlorobenzylidene malononitrile. Toxicologist, 3, 64.
21. Ballantyne B (1984). Toxicology. In: Kirk-Othmer: Encyclopedia of Chemical Technology, Supplemental Volume, Third Edition (M Grayson, ed), pp. 894-924. New York, NY, USA: John Wiley & Sons, Inc.
22. Ballantyne B (1987). Clinical toxicology and forensic aspects of riot control chemicals. In: Abstracts of the 24th International Meeting, International Association of Forensic Toxicologists, Banff. (GR Jones and PP Singer eds.) pp. 484-504. Alberta, Canada: University of Alberta Printing Services.
23. Ballantyne B (1998). Acute inhalation toxicity of phosphorus pentoxide smoke. Toxic Sub Mech, 17, 251-266.
24. Ballantyne B (1999)a). Peripheral sensory irritation: basics and applications. In: General and Applied Toxicology, Volume 2, Second Edition. (B Ballantyne, TC Marrs and T Syversen, eds), pp. 611-630. London, UK: MacMillan Reference.
25. Ballantyne B (1999b). Toxicology related to the eye. In: General and Applied Toxicology, Volume 2, Second Edition edited by (B Ballantyne, TC Marrs and T Syversen, eds), pp. 737-774. London, UK: MacMillan Reference.
26. Ballantyne B. (1999c). Repeated exposure toxicity. In: General and Applied Toxicology, Volume 1, Second Edition (B Ballantyne, TC Marrs and T Syversen, eds.), pp. 55-66. London, UK: Macmillan Reference.
27. Ballantyne B (2005)a). Peripheral chemosensory irritation with particular reference to the respiratory tract. In: Inhalation Toxicology, Second Edition. (H Salem and A Katz, eds), pp. 269-306. Boca Raton, FL, USA: CRC Press.
28. Ballantyne B (2005b). The occupational toxicologist: professionalism, morality and ethical standards in the context of legal and non-litigation issues. J Appl Toxicol, 25, 496-513.
29. Ballantyne B (2006). Medical management of the traumatic consequences of civil unrest incidents: causation, clinical approaches, needs, and advance planning criteria. Toxicol Rev, in press.
30. Ballantye B and Beswick F (1972). On the possible relationship between diarrhea and ochlorobenzylidene malononitrile (CS). Med Sci Law, 12, 121-128.
31. Ballantyne B and Callaway S (1972). Inhalation toxicology and pathology of animals exposed to ochlorobenzylidene malononitrile (CS). Med Sci Law, 12, 43-65.
32. Ballantyne B and Clifford EC (1978). Short term inhalation toxicology of cinnamic acid smoke. J Combust Toxicol, 5, 253-260.
33. BallantyneBand JohnsonWG (1974a). Safety aspects of the rubber bursting grenade. Med Sci Law, 14, 144-150.
34. Ballantyne B and Johnson WG (1974b). o-Chlorobenzylidene malononitrile (CS) and the healing of cutaneous injuries. Med Sci Law, 14, 93-97.
35. Ballantyne B and Salem H (2004). Forensic aspects of riot control agents. In: Riot Control Agents. Issues in Toxicology, Safety, and Health (EJ Olajos and W Stopford, eds), pp. 231-258. Boca Raton, FL, USA: CRC Press.
36. Ballantyne B and Salem H (2006). Screening smokes; applications, toxicology, clinical considerations, and medical management. In: Chemical Warfare Agents: chemistry, pharmacology and therapeutics. Second edition (H Salem and BJ Lukey, eds). Boca Raton, FL, USA: CRC Press, in press.
37. Ballantyne B and Swanston DW (1973). The irritant potential of dilute solutions of orthochlorobenzylidene malononitrile (CS) on the eye and tongue. Acta Pharmacol Toxicol, 32, 266-277.
38. Ballantyne B and Swanston DW (1974). The irritant effects of dilute solutions of dibenzoxazepine (CR) on the eye and tongue. Acta Pharmacol Toxicol, 35, 412-423.
39. Ballantyne B and Swanston DW (1978). The comparative acute mammalian toxicity of 1-chloroacetophenone (CN) and 2-chlorobenzylidene malononitrile (CS). Arch Toxciol, 40, 75-95.
40. Ballantyne B, Gazzard MF and Swanston DW (1972). Effects of solvents and irritants on intraocular pressure in the rabbit. J Physiol London, 266, 12P-14P.
41. Ballantyne B, Gazzard MF and Swanston DW (1973a). Eye damage caused by crystal violet. Br J Pharmacol, 49, 181-182.
42. Ballantyne B, Beswick W and Price Thomas D (1973b). The presentation and management of individuals contaminated with solutions of dibenzoxazepine (CR). Med Sci Law, 13, 265-268.
43. Ballantyne B, Gazzard MF, Swanston DW et al. (1974). The ophthalmic toxicology of o-chlorobenzylidene malononitrile (CS). Arch Toxicol, 32, 149-168.
44. Ballantyne B, Gazzard MF, Swanston DW et al. (1975). The comparative ophthalmic toxicology of 1-chloroacetophenone (CN) and dibenz(b.f)-1,4-oxazepine (CR). Arch Toxicol, 34, 183-201.
45. Ballantyne B, Gall D and Robson DC (1976a). Effects on man of drenching with dilute solutions of o-chlorobenzylidene malononitrile (CS) and dibenz(b.f)-1,4-oxazepine (CR). Med Sci Law, 6, 159-170.
46. Ballantyne B, Gazzard MF and Swanston DW (1976b). The ophthalmic toxicology of dichloromethane. Toxicology, 6, 173-187.
47. Ballantyne B, Gazzard MF and Swanston D (1977a). Applanation tonometry in ophthalmic toxicology. In: Current Approaches in Toxicology edited by (B Ballantyne, ed.), pp. 158-192. Bristol, UK: John Wright.
48. Ballantyne B, Gazzard MF and Swanston DW (1977b). Irritancy testing by respiratory exposure. In: Current Approaches in Toxicology (B Ballantyne, ed.), pp. 129-138. Bristol, UK: John Wright.
49. Ballantyne B, Marrs TC and Syversen T (1999a). Fundamentals of Toxicology. In: General and Applied Toxicology, Volume 1, Second Edition (B Ballantyne, TC Marrs and T Syversen, eds), pp. 1-32. London, UK: MacMillan Reference.
50. Ballantyne B, Marrs TC and Syversen T (eds) (1999b). General and Applied Toxicology, Volume 2, Part 2, Second Edition. London, UK: MacMillan Reference.
51. Barlow N (2000). Letter to the Editor. Resuscitation, 47, 91-92.
52. Bauchinger M and Schmid E (1992). Clastogenicity of 2-chlorobenzylidene malononitrile (CS) in V79 Chinese hamster cells. Mutat Res, 282, 231-234.
53. Bayeaux-Dunglas M-C, Depars P, Touati M-A et al. (1999). Occupational asthma in a teacher after repeated exposure to tear gas. Rev Mal Resp, 16, 558-559.
54. BBC (1997). CS spray used to subdue pensioner. British Broadcasting Corporation News, UK Edition, dated 5 December 1997 (http://new.bbc.co.uk/1/hi/uk/37188.stm).
55. BBC (1998a). CS gas 'unprovoked', say campaigners. British Broadcasting Corporaton News, UK Edition, dated 29 June 1998 (http://news.bbc.co.uk/1/hi/uk/122548.stm).
56. BBC (1998b). Inquest into pensioner's death after CS spray. British Broadcasting Corporation News, UK Edition, dated 25 September 1998 (http://nwes.bbc.co.uk/1/hi/uk/180389.stm).
57. BBC (1999). CS gas used on psychiatric patients. British Broadcasting Corporation News, UK Edition, dated 3 August 1999 (http://news.bbc.co.uk/1/hi/health/41890.stm).
58. BBC (2001a). Police use pepper spray. British Broadcasting Corporation News, UK Edition, dated 16 March 2001 (http://new.bbc.co.k/1/hi/uk/1223786.stm).
59. BBC (2001b). Police defend use of CS spray. British Broadcasting Corporation News, UK Edition, dated 29 May 2001 (http://news.bbc.co.uk/1/i/scotland/1357325.htm).
60. BBC (2002a). First Welsh force adopts pepper spray. British Broadcasting Corporation News, UK Edition, dated 5 August 2002 (http://news.bbc.co.uk/1/hi/wales/2173434.stm)
61. BBC (2002b). Police called to noisy party. British Broadcasting News, UK Edition, dated 25 November 2002 (http://news.bbc.co.uk/1/hi/england/2512045.stm)
62. BBC (2002c). 45 hurt in nightclub gas incident. British Broadcasting Corporation News, UK Edition, dated 16 November 2002 (http://news.bc.co.uk/1/hi/england/2484407.stm)
63. BBC (2003a). Inquest told police used CS gas. British Broadcasting Corporation News, UK Edition, dated 20 January 2003 (http://new.bbc.co.uk/1/hi/england/2678423.stm)
64. BBC (2003b). Open verdict in 'CS gas death'. British Broadcasting Corporation News, UK Edition, dated 31 January 2003 (http://news.bbc.co.uk/1/hi/england/2714675.stm)
65. BBC (2003c). Schizophrenic sprayed with CS gas. British Broadcasting Corporation News, UK Edition, dated 18 February 2003 (http://news.bbc.co.uk/1/hi/england/2776637.stm)
66. BBC (2003d). Violence erupts at boxing match. British Broadcasting Corporation News, UK Edition, dated 24 November 2003 (http://news.bc.c.uk/1/hi/england/southyorkshire/3233064.stm)
67. BBC (2003e). CS gas in school-3 suspended. British Broadcasting Corporation News, UK Edition, dated 23 September 2003 (http://news.bbc.uk.co/1/hi/wales/northeast/3131668.stm)
68. BBC (2003f). Boy charged after gas incident. British Broadcasting Corporation News, UK Edition, dated 7 October 2003 (http://news.bbc.co.k/1/hi/scotland/3170912.stm)
69. BBC (2003g) Police defend use of gas. British Broadcasting Corporation News, UK Edition, dated 6 October 2003 (http://news.bbc.co.uk/1/hi/england/derbyshire/3169548.stm).
70. BBC (2003h). Baton rounds 'more dangerous'/Doctors urge rubber bullet ban. British Broadcasting Corporation News, World Edition (http://new.bbc.co.uk/2/hi/uk.new/northern.ireland/2926225stm&health/20033999.stm)
71. BBC (2004a). Concern over effects of CS spray. British Broadcasting Corporation News, UK Edition, dated 23 August, 2004 (http://news.bbc.co.uk/hi/health/3584560.stm)
72. BBC (2004b). Man sought after CS gas incident. British Broadcasting Corporation News, UK Edition, dated 28 May 2004 (http://news.bbc.co.uk/1/hi/scotland/3756049.stm)
73. BBC (2004c). Jail term for nightclubCSattack. British Broadcastng Corporation News, UK Edition, dated 5 October 2004 (http://news.bbc.co.uk/1/hi/derbyshire/3717490.stm).
74. BBC (2004d). CS replaced with 'safer option'. British Broadcasting Corporation News, UK Edition, dated 21 December 2004 (http://bbc.news.uk.co/1/hi/england/leicestershire/4114761.stm)
75. BBC (2004e). Two shops in CS attacks. British Broadcasting Corporation News, UK Edition, Dated 13 February 2004 (http://news.bbc.co.uk/1/hi/england/derbyshire/3486649.stm)
76. BBC (2004f). CS spay 'used on teenage boys'. British Broadcasting Corporation News, UK Edition, dated 16 October 2004 (http://news.bbc.co.uk/1/hi/england/manchester/3749510.stm)
77. BBC (2005a). CS gas released in tube station. British Broadcasting Corporation News, UK Edition, dated 18 May 2005 (http://new.bbc.co.uk/1/hi/uk/4560591.stm)
78. BBC (2005b). Police acused in CS spray claim. British Broadcasting Corporation News, UK Edition, dated 2 May 2005 (http://news.bbc.co.uk/1/hi/england/lincolnshire/4504069.stm)
79. BBC (2005c). 'Chilli' spray to replace CS gas. British Broadcasting Corporation News, UK Edition, dated 27 June 2005 (http://news.bbc.co.uk/1/hi/england/beds/bucks/herts/4626779.stm)
80. BBC (2005d). Police accused of CS spray claim. British Broadcasting Corporation News, UK Edition, dated 2 May 2005 (http://news.bbc.co.uk/1/hi/england/lincolnshire/4504069.stm)
81. BBC (2005e). Man, 23, held overCS gas attack. British Broadcasting Corporation News, UK Edition, dated 7 February 2005 (http://news.bbc.co.uk/1/hi/england/manchester/4243299.stm).
82. BBC (2005f). CS spray hits four in nightclub. British Broadcasting Corporation News, UK Edition, dated 10 April 2005 (http://news.bbc.co.uk/1/hi/england/southerncounties/4429769.stm)
83. BBC (2005g). CS spray used at student's union. British Broadcasting Corporation News, UK Edition, dated 4 May 2005 (http://news.bbc.co.uk/1/hi/wales/mid/4514243.stm)
84. Bell MD, Rao VJ, Wetli CV et al. (1992). Positional asphyxia in adults: a series of 30 cases from the Dade and Broward County Florida Medical Examiners Offices from 1982 to 1990. Am J Forens Med Pathol, 13, 101-107.
85. Beswick FW, Holland P and Kemp KH (1972). Acute effects of exposure to o-chlorobenzylidene malononitrile (CS) and the development of tolerance. Br J Indust Med, 29, 298-306.
86. Bhattacharya ST and Haywood AW (1993). CS gas-implications for the anaesthetist. Anaesthesia, 48, 896-897.
87. Billmere DF, Vinicur C, GindaMet al. (1996). Pepperspray-induced respiratory treated with extracorporeal membrane oxygenation. Pediatrics, 96, 961-963.
88. Blaho K and Stark MM (2000). CS is a particulate spray, not a gas. Br Med J, 321, 46.
89. Blanc P, Lui D, Juarez C et al. (1991). Cough in hot pepper workers. Chest, 99, 27-32.
90. Blumenfeld R and Meselson M (1971). The military value and political implications of the use of riot control agents in chemical warfare. In: The Control of Chemical and Biological Weapons, pp. 64-93. New York, NY, USA: Carnegie Endowment.
91. Boulton ML, Abellera J, Lemmings J et al. (2005). Brief report: terrorism and emergency preparedness in State and territorial public health departments-United States, 2004. Morbid Mortal Week Rep, 54, 459-460.
92. Brekell A and Bodiwala GG (1998). CS-gas exposure in a crowded night club: the consequences for an accident and emergency department. J Accid Emerg Med, 15, 56-64.
93. Brimblecombe RW, Green DM and Muir AW (1972). Pharmacology of o-chlorobenzylidene malononitrile. Br J Pharmacol, 29, 298-306.
94. Brooks SM, Weiss MA and Bernstein L (1985). Reactive airways dysfunction syndrome. Case reports of persistent airways hyper-reactivity following high-level irritant exposures J Occup Med, 27, 473-476.
95. Brown I, Takeuchi D and Challoner K (2000). Corneal abrasions associated with pepper spray exposure. Am J Emerg Med, 18, 271-272.
96. Burton EG, Clarke MI, Miller RA et al. (1982). Generalizations and characteristics of red phosphorus smoke aerosols for inhalation exposure of laboratory animals. Am Indust Hyg Assoc J, 43, 767-772.
97. Busker RWand van Helden HPM (1998). Toxicological evaluation of pepper spray as a possible weapon for the Dutch police force. Risk assessment and efficacy. Am J Forens Med Pathol, 19, 309-316.
98. Caterina MJ and Julius D (2001). The vanilloid receptor: a molecular gateway to the pain pathway. Ann Rev Neurosci, 24, 487-517.
99. Chan OY, Lee CS, Tan TK et al. (1990). Health problems among spice grinders. Jpn Soc Occup Med, 40, 111-115.
100. Chapman AJ and White C (1978). Death resulting from lachrymatory agents. J Forens Sci, 23, 247-256.
101. Chung CW and Giles AL Jr (1972). Sensitization of guinea pigs to alpha-chloroacetophenone (CN) and ortho-chlorobenzylidene malononitrile (CS) tear gas chemicals. J Immunol, 109, 284-293.
102. Cole TJ, Cotes JE, Johnson GR et al. (1975). Comparison of effects of ammonia and CS aerosol upon exercise ventilation and cardiac frequency in healthy men. J Physiol London, 252, 28P-29P.
103. Colgrave HF, Lee C, Marrs TC et al. (1983). Repeated dose inhalation toxicity and mutagenicity-status of CR (dibenz(b.f)-1,4-oxazepine). Br J Pharmacol, 78, 169.
104. Conner WC (1967). Human violence stopped by dartshooting tranquilizer gun. J Amer Med Assoc, 201, 34-35.
105. Constant HL and Cordell GA (1996). Nonivamide, a constituent of capsicum oleoresin. J Nat Prod, 59, 425-429.
106. Cooper TH, Guzinski JA and Fisher C (1991). Improved high performance liquid chromatography method for the determination of major capsaicinoids in capsicum oleoresins. J Agr Food Chem, 39, 2253-2256.
107. Cotes JE, Dabbs JM, Evans MR et al. (1972a). Effect of CS aerosol upon lung transfer and alveolar volume in healthy men. QJ Expt Physiol, 57, 199-206.
108. Cotes JE, Evans RL, Johnson GR et al. (1972b). The effect of CS aerosol upon exercise ventilation and cardiac frequency in healthy men. J Physiol London, 222, 77P-78P.
109. Cucinell SA, Swentzel K, Biskup R (1971). Biochemical interactions and metabolic fate of riot control agents. Fed Proc, 30, 86-91.
110. D'Agostino PA and Provost LR (1985). Gas chromatographic retention indices of chemical warfare agents and simulants. J Chromatogr, 331, 47-54.
111. D'Agostino PA and Provost LR (1995). Analysis of irritants by capillary column gas chromatography tandem mass spectrometry. J Chromatogr Anal, 695, 65-73.
112. Damhoeri A, Hosono A, Itoh T et al. (1985). In vitro mutagenicity tests on capsicum pepper, shallot and nutmeg oleoresins. Agr Biol Chem, 49, 1519-1520.
113. Dean-Drummond A (1975). Riot Control. London, UK: Royal United Services Institute for Defence Studies.
114. DitterDMand Heal CS (2004). Application and use of riot control agents. In: Riot Control Agents. Issues in Toxicology, Safety, and Health (EJ Olajos andW Stopford, eds), pp. 17-24. Boca Raton, FL, USA: CRC Press.
115. Duenas A, Filipe S, Ruz-Mambrilla M et al. (2000). CO poisoning caused by inhalation of CH3Cl contained in personal defense sprays. AmJ Emerg Med, 18, 120-121.
116. Durnford JM (2004). Genetic toxicity of riot control agents. In: Riot Control Agents. Issues in Toxicology, Safety, and Health (EJ Olajos andWStopford, eds), pp. 183-200. Boca Raton, FL, USA: CRC Press.
117. Euripidou E, MacLehose R and Fletcher A (2004). An investigation into the short term and medium term health impacts of personal incapacitant sprays. A follow up of patients reported to the National Poisons Information Service (London). Emerg Med J, 21, 548-552.
118. Evans EH (1945). Casualties following exposure to zinc chloride smoke. Lancet, ii, 368-370.
119. Feinsilver L, Chambers HA, Vocci FJ et al. (1971). Some metabolites of CS from rats. Edgewood Arsenal Technical Report Series, Number 4521, dated May 1971. Edgewood Arsenal, MD, USA: Department of the Army.
120. Ferslew KE, Orcutt RH and Hagardorn AH (1986). Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile. J Forens Sci, 31, 658-665.
121. FisherAA (1970). Dermatitis due to tear gases (lachrymators). Br J Dermatol, 9, 91-95.
122. Fitzgerald M (1983). Capsaicin and sensory neurons-a review. Pain, 15, 109-130.
123. Forrester AB and Stanley SK (2003) The epidemiology of pepper spray exposures reported in Texas in 1998-2002. Vet. Human Toxicol, 45, 27-33.
124. Foster RW and Weston KM (1986). Chemical irritant algesia assessed using the human blister base. Pain, 25, 269-278.
125. Frankenberg L and Sörbo B (1973). Formation of cyanide from o-chlorobenzylidene malononitrile and its toxicological significance. Arch Toxicol, 31, 99-108.
126. Frazer RM (1971). The cost of commotion: an analysis of the psychiatric sequelae of the 1969 Belfast riots. Br J Psychiat, 118, 257-264.
127. Frazier CA (1976). Contact allergy to mace. J Am Med Assoc, 236, 25-26.
128. French MC, Harrison JM, Inch TD et al. (1983a). The fate of dibenz(b,f)-1,4-oazepine (CR) in the rat, rhesus monkey, and guinea pig, part 1, metabolism in vivo. Xenobiotica, 13, 345-359.
129. French MC, Harrison JM, Newman J et al. (1983b). The fate of dibenz(b.f)-1,4-oxazepine (CR) in the rat, part iii, the intermediary metabolites. Xenobiotica, 13, 373-381.
130. Fuchs T and in der Wiesche M (1990). Contact dermatitis from CN and CS (tear gas) among demonstrators. Z Haut, 65, 25-28.
131. Fujimura M, Kamio Y, Sakamoto S et al. (1992). Tachyphylaxis to capsaicin-induced cough and its reversal by indomethacin, in patients with the sinobronchial syndrome. Clin Autonomic Res, 2, 397-401.
132. Fuller RW (1990). The human pharmacology of capsaicin. Arch Int Pharmacodyn, 303, 147-155.
133. Fuller RW, Dixon CM and Barnes PJ (1985). Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol, 58, 1080-1084.
134. FungT, Jeffery W and BeveridgeAD (1982) The identification of capsaicinoids in tear gas spray. J Forens Sci,, 27, 812-821.
135. Furnival B, Harrson JM, Newman J et al. (1983). The fate of dibenz(b.f)-1,4-oxazepine in the rat: part II, metabolism in vitro. Xenobiotica, 13, 361-372.
136. Gaskins JR, Hehir RM, McCaulley DF et al. (1972). Lachrimating agents (CS and CN) in rats and rabbits. Arch Environ Health, 24, 449-454.
137. Georgopoulas PG, Fedele P, Shade P et al. (2004). Hospital response to chemical terrorism: personal protective equipment, training, and operations planning. Am J Indust Med, 46, 432-445.
138. Gonzales TA, Vance M, Helpern M, et al. (1954). Legal Medicine. New York, NY, USA: Appleton-Century Crofts.
139. Govindarajan VS and Sathyanaravana MN (1991). Capsicum-production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism: structure, pungency, pain and desensitizing sequences. Crit Rev Food Sci Nutrit, 23, 207-288.
140. Granfield G, Onnen J and Petty CS (1994). Pepper spray and in-custody deaths. Executive Brief, March 1994. Alexandria, VA, USA: International Association of Chiefs of Police.
141. Grant WM (1986). Toxicology of the Eye, Third Edition, pp. 207-208. Springfield, IL, USA: Charles C. Thomas.
142. Grawe J, Nusse M and Adler I-D (1997). Quantitative and qualitative studies of micronucleus induction in mouse erythrocytes using flow cytometry. 1. Measurement of micronucleus induction in peripheral blood polychromatic erythrocytes by chemicals with known or suspected genotoxicity. Mutagenesis, 12, 1-8.
143. Gray PJ (1995). Treating CS gas injuries of the eye. Br Med J, 311, 871.
144. Gray PJ (2004). Formulation affects toxicity. Br Med J, 321, 46.
145. Greaves JA(2 (2000) The automobile as a confined space for toxic chemical hazards. Am J Indust Med,, 38, 481-482.
146. Gutentag PL, Hart J, Owens EJ et al. (1960). The evaluation of CS aerosols as a riot control agent. US Army Chemical Warfare Laboratories Technical Report, CWLR 2365. Bethesda, MD, USA: Army Chemical Center.
147. Hass JS, Whipple RE, Grant PM et al. (1997). Chemical and elemental comparison of two formulations of oleoresin capsicum. Sci Justice, 37, 15-24.
148. Hayes AW (2001). Principles and Methods of Toxicology, Fourth Edition. Philadelphia, PA, USA: Taylor & Francis.
149. Hayes AG, Skingle M and Tyers MB (1980). The antinociceptive effects of single doses of capsaicin in the rodent. Br J Pharmacol, 70, 96P-97P.
150. HayesAG, SkingleMand TyersMB (1981) Effects of single doses of capsaicin on nociceptive thresholds in the rodent. Neuropharmacology,, 20, 505-511.
151. Hayman CR and Berkely MJ (1971). Health care for war demonstrators in Washington, April-May, 1971. Med Ann Distr Columbia, 40, 633-637.
152. Hellreich A, Goldman RH, Bottiglieri NG et al. (1967). The effect of thermally-generated CS aerosols on Human skin. Edgewood Arsenal Technical Report Series, Number 4075, dated January 1967. Edgewood Arsenal, MD, USA: Department of the Army.
153. Hill AR, Silverberg NB, Mayorga D et al. (2000). Medical hazards of the tear gas CS. A case of persistent, multisystem, hypersensitivity reaction and a review of the literature. Medicine, 79, 234-240.
154. HMSO (1969). Report of the enquiry into the Medical and Toxicological aspects of CS (Orthochlorobenzylidene malononitrile). Part 1-Enquiry into the Medical Situation following the use of CS in Londonderry on 13th and 14th August, 1969. Cmnd 4173. London, UK: Her Majesty's Stationary Office.
155. HMSO (1971). Report of the enquiry into the Medical and Toxicological aspects of CS (Orthochlorobenzylidene malononitrile). Part 2. Enquiry into Toxicological Aspects ofCSand its use for Civil Purposes. Cmnd 4775. London, UK: Her Majesty's Stationary Office. Part 2
156. Hoffmann DH (1967). Eye burns caused by tear gas. Br J Ophthalmol, 51, 265-268.
157. Holland P (1974). The cutaneous reactions produced by dibenzoxazepine (CR). Br J Dermatol, 90, 657-665.
158. Holland P and Seabright M (1971). Effects of CS on lymphocyte chromosome structur. In: Clinical and Preclinical Studies on Ortho Chlorobenzylidene Malononitrile (CS), Technical Note Number 82. Porton Down, Salisbury, UK: Chemical Defence Establishment.
159. Holland P and White RG (1972). The cutaneous reactions produced by o-chlorobenzylidene malononitrile and ω-chloroacetophenone when applied directly to the skin of human subjects. Br J Dermatol, 86, 150-154.
160. Holopainen JM, Molnen JAO, Hack T et al. (2003). Toxic carriers in pepper sprays may cause corneal erosion. Toxicol Appl Pharmacol, 186, 155-162.
161. Hopping W (1969). Lesions caused by close-range shots from from gas pistols. Klin Monatsbl Augenheilkd, 135, 270-272.
162. Horowitz BZ (1986). Carboxyhemoglobinemia caused by inhalation of methylene chloride. Am J Emerg Med, 18, 691-695.
163. Hu H and Cristani D (1992). Reactive airways dysfunction after exposure to tear gas. Lancet, 339, 1535.
164. Hu H, Fine J, Epstein P et al. (1989). Tear gas-harassing agent or toxic chemical weapon? J AmMed Assoc, 262, 660-663.
165. Jane I and Wheals BB (1972). Chromatographic characterization of lachrymatory agents in tear gas aerosols. J Chromatogr Anal, 70, 151-153.
166. Jang JJ, Cho KJ, Lee YS et al. (1991). Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat. J Korean Med Sci, 6, 31-36.
167. Jansco G, Kiraly E and Jansco-Gabor A (1977). Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature, 270, 741-743.
168. Jansco G, Karcsu S, KiralyEet al. (1984). Neurotoxininduced nerve cell degeneration: possible involvement of calcium. Brain Res, 295, 211-216.
169. Johnson FA and Stonehill RB (1961). Chemical pneumonitis from inhalation of zinc chloride. Dis Chest, 40, 619-624.
170. Jolly HA and Carpenter CL (1968). Tear gas dermatitis. J Am Med Assoc, 203, 808.
171. Jones JRN and Israel MS (1970). Mechanism of toxicity of injected CS gas. Nature (London), 228, 315-317.
172. Kales SN and Cristiani DC (2004). Acute chemical emergencies. New England J Med, 350, 800-808.
173. Karagama YG, Newton JR and Newbegin CJR (2003). Short-term and long-term physical effects of exposure to CS spray. J R Soc Med, 96, 172-174.
174. Kawada T and Iwai K (1985). In vitro and in vivo metabolism of dihydrocapsaicin, a pungent principle of hot pepper in rats. Agr Biol Chem, 49, 441-448.
175. Kawada T, Suzuki T, Takahashi M et al. (1984). Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin. Toxicol Appl Pharmacol, 72, 449-456.
176. Kemp KH and Weatherell A (1975). The subjective detection of CR contamination in drinking water. CDE Technical Note, Number 238, dated June 1975. Porton Down, Salisbury, UK: Ministry of Defence, Chemical Defence Establishment.
177. Kemp KH and Wilder WB (1972). Taste perception and palatability following CR exposure. Med Sci Law, 12, 113.
178. Kim JP, Park JG, Lee MD et al. Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N-nitrosoguanidine in rats. Jpn J Surg, 15, 427-437.
179. Kimber I and Dearman RJ (1999). Evaluation of respiratory sensitization potential of chemicals. In: General and Applied Toxicology, Volume 2, Second Edition. (B Ballantyne, TC Marrs and T Syversen, eds), pp. 701-720. London, UK: Macmillan Reference.
180. King K, Tunget CI, Turche B et al. (1995). Severe contact dermatitis from chemical mace containing 1-chloroaetophenone. J Toxicol Cut Ocul Toxicol, 14, 57-62.
181. Kirby ML, Gale TF and Mattio TG (1982). Effects of prenatal capsaicin treatment on fetal spontaneous activity, opiate receptor binding, and acid phosphatase in in spinal cord. Exp Neurol, 76, 298-308.
182. Kling RP (1969). Chemical mace-a controversy. Eye Ear Nose Throat Monthly, 48, 13.
183. Kluchinsky TA Jr, Savage PB, SheelyMVet al. (2001). Identification of CS-derived compounds formed during heat-dispersion of CS riot control agent. J Microcol Sep, 13, 186-190.
184. Kluchinsky TAJr, Savage PB, Fitz R et al. (2002). Liberation of hydrogen cyanide and hydrogen chloride during high-temperature dispersion of CS riot control agent. Am Ind Hyg Assoc J, 63, 493-496.
185. Krapf R (1981). Acute exposure to CS tear gas and clinical observations. Schweiz Med Wschr, 111, 2056-2060.
186. Krebs J, Prime RJ and Leung K (1982). Rapid determination of capsaicin, CN and CS in tear gas by HPLC. Can Soc Forens Sci J, 15, 29-33.
187. Kumar P, Flora SJ, Pant SC et al. (1994). Toxicological evaluation of 1-chloroacetophenone and dibenz[b.f]-1,4-oxazepine after repeated inhalation exposure in mice. J Appl Toxicol, 14, 411-416.
188. LaHann TR (1986). Effect of capsaicin on croton oil and TPAinduced carcinogenesis and inflammation. J West Pharmacol Soc, 29, 145-149.
189. Laibson PR and Oconor J (1979). Explosive tear gas injuries of the eye. Trans Am Acad Ophthalmol Otolaryng, (July-August), 811-819.
190. Lancet (1971). Leading Article. Toxicity of CS. Lancet, 2, 698.
191. Laurent JF, Richetr F and Michel A (1999). Management of victims of urban chemical attack: the French approach. Resuscitation, 42, 141-149.
192. Leadbeater L (1973). The absorption of ochlorobenzylidene malononitrile (CS) by the respiratory tract. Toxicol Appl Pharmacol, 25, 101-110.
193. Leadbeater L, Sainsbury GL and Utley D (1973). ortho-Chlorobenzylmalononitrile: a metabolite formed from ortho-chorobenzylidene malononitrile (CS). Toxicol Appl Pharmacol, 25, 111-116.
194. Lee SS and Kumar S (1980). Metabolism in vitro of capsaicin, a pungent principle of red pepper, with rat liver homogenates. In: Microsomes, Drug Oxidation, and Chemical Carcinogenesis, Volume 2. (MJ Coon, AH Conney, RW Estabrook, eds), pp. 1009-1012. NewYork,NY, USA: Academic Press.
195. Lee RJ, Yolton RL, Schnider C et al. (1996). Personal defense sprays: effects and management of exposure. Am Optomet Assoc, 67, 548-560.
196. Leenutaphong V and Goerz G (1989). Allergic contact dermatitis from chloroacetophenone (tear gas). Contact Derm, 20, 316.
197. Leopald IH and Lieberman TW (1971). Chemical injuries of the cornea. Fed Proc, 30, 92-95.
198. Levine RA and Stahl CJ (1968). Eye injury caused by tear gas weapons. Am J Ophthlmol, 65, 497-508.
199. Lewer N and Schofield S (1997). Non-Lethal Weapons: A Fatal Attraction? London, UK: Zed Books Ltd.
200. Lifschultz BD and Donoghue ER (1991). Deaths in custody. In: Legal Medicine, pp. 45-71. Philadelphia, PA, USA: Saunders.
201. Loriot J and Tourte J (1990). Hazards of contact lenses used by workers. Int Arch Occup Environ Health, 62, 105-108.
202. Luke JL and Reay DT (1992). The perils of investigating and certifying deaths in police custody. Am J Forens Med Pathol, 13, 98-100.
203. Lundberg JM and Saria A (1982). Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons. Acta Physiol Scand, 116, 473-476.
204. Lundberg L and Lundberg JM (1984). Capsaicin sensitive sensory neurons mediate the response to nasal irritation induced by the vapor phase of cigarette smoke. Toxicology, 33, 1-7.
205. Lyons HA (1971). Psychiatric sequelae of the Belfast riots. Br J Psychiat, 118, 265-273.
206. MacLeod IF (1969). Chemical mace: ocular affects in rabbits and monkeys. J Forens Sci, 14, 34-37.
207. Macrae WG, Willinsky MD and Basu PK (1970). Corneal injury caused by aerosol irritant projectors. Can J Ophthalmol, 5, 3-11.
208. Makles Z, Sliwakowski M and Nousiainen P (1999). Detection of dibenzo[b,f][1,4]oxazepine in the presence of other lacrimators with thin layer chromatography. Chem Anal, 44, 257-262.
209. Mankes RF and Mankes KM (2004). Reproductive and developmental toxicology of riot control agents. In: Riot Control Agents. Issues in Toxicology, Safety, and Health (EJ Olajos and W Stopford, eds), pp. 161-181. Boca Raton, FL, USA: CRC Press.
210. Marrs TC, Gray MI, Colgrave HF et al. (1982). A repeated dose study of the toxicity of CR applied to the skin of mice. Toxicol Lett, 13, 259-265.
211. Marrs TC, Clifford EC and Colgrave HF (1983a). Pathological changes produced by exposure of rabbits and rats to smokes from mixtures of hexachloroethane and zinc oxide. Toxicol Lett, 19, 247-252.
212. Marrs TC, Clifford E and Colgrave HF (1983b). Late inhalation toxicology and pathology produced by exposure to a single dose of 2-chlorobenzylidene malononitrile (CS) aerosol in rats and hamsters. Med Sci Law, 23, 257-265.
213. Marrs TC, Colgrave HF, Cross NL et al. (1983c). A repeated dose study of the toxicity of inhaled 2-chlorobenzylidene malononitrile (CS) aerosol in three species of laboratory animal. Arch Toxicol, 52, 183-198.
214. Marrs TC, Colgrave HF and Cross NL (1983d). A repeated dose study of the toxicity of technical grade dibenz(b.f)-1,4-oxazepne in mice and hamsters. Toxicol Lett, 17, 13-21.
215. Marrs TC, Colgrave HF, Gazzard MF et al. (1984). Inhalation toxicology of a smoke containing Solvent Yellow 33, Disperse Red 9 and Solvent Green 3 in laboratory animals. Human Toxicol, 3, 298-308.
216. Marrs TC, Colgrave HF, Edginton JAG et al. (1988). The repeated dose toxicity of zinc oxide/hexachloroethane smoke. Arch Toxicol, 62, 123-132.
217. Marrs TC, Colgrave HF, Edginton JAG et al. (1989). Repeated dose inhalation toxicity of cinnamic acid smoke. J Hazard Mater, 21, 1-15.
218. Marrs TC, Allen IV, Colgrave HF et al. (1991). Neurotoxicity of 1-methoxycycloheptatriene-a Purkinje cell toxicant. Human Exp Toxicol, 10, 93-101.
219. Marrs TC, Maynard RL and Sidell ER (1996). Chemical Warfare Agents: Toxicology and Treatment, pp. 221-230. Chichester, UK: JohnWiley & Sons, Ltd.
220. Marsh SJ, Stansfeld CE, Brown DA et al. (1987). The mechanism of action of capsaicin on sensory c-type neurones and their actions in vitro. Neuroscience, 23, 275-289.
221. Marshall TK (1976). Wounds and trauma. In: Gradwohl's Legal Medicine, Third Edition (FE Camps, AE Robinson and BGB Lucas, eds), pp. 294-296. Bristol, UK: John Wright.
222. Martling CR (1987). Sensory nerves containing tachykinins and CGRP in the lower airways. Acta Physiol Scand, 130, Supplement 563, 1-57.
223. MarzulliFN and Maibach HI (1974). The use of graded concentrations in studying skin sensitizers: experimental contact sensitization in man. Food Cosmet Toxicol, 2, 219-227.
224. Maynard RL (1999). Toxicology of chemical warfare agents. In: General and Applied Toxicology, Volume 3, Second Edition (B Ballantyne, TC Marrs and T Syversen, eds), pp. 2079-2109. London, UK: Macmillan Reference.
225. McDonald DM (1992). Infections intensify neurogenic plasma extravasation in the airway mucosa. Am Rev Resp Dis, 146, S40-S44.
226. McElhatton PR, Sidhu S and Thomas SHL (2004). Exposure to CS gas in pregnancy. J Toxicol Clin Toxicol, 42, 547.
227. McGregor DB, Brown A, Cattanach P et al. (1988). Responses of the L5178K tk+/tk-mouse lymphoma cell forward mutation assay II. 18 coded chemicals. Environ Mol Mutagen, 11, 91-118.
228. McLaughlin V and Siddle B (1998). Law enforcement and custody deaths. The Police Chief (August), 38-41.
229. McNamara BP, Vocci FJ and Owens EJ (1968). The toxicology of CN. Edgewood Arsenal Technical Report Series, Number 4207, dated December 1968. Edgewood Arsenal, MD, USA: Department of the Army.
230. McNamara BP, Owens EJ, Weimer JT et al. (1969). Toxicology of riot control chemicals-CS, CN, and DM. Edgewood Arsenal Technical Report Series, Number 4309, dated March 1969. Edgewood Arsenal, Bethesda, MD, USA: Department of the Army.
231. Meshram GP, Malini RP and Rao KM (1992). Mutagenicity evaluation of riot control agent o-chlorobenzylidene malononitrile (CS) in the Ames/microsome test. J Appl Toxicol, 12, 377-384.
232. Mesilaakso M (1996). Analysis of the 1H and 13C[1H] NMR spectral parameters of tear gases, α-chloroacetophenone, bibenz[b,f][1,4]oxazepine and 2-chlorobenzylidene malononitrile. Mag Reson Chem, 34, 989-994.
233. Miller BM and Nusse N (1993). Analysis of micronuclei induced by 2-chlorobenzylidene malononitrile (CS) using fluorescence in situ hybridization with telemetric and centrometric DNA probes and flow cytometry. Mutagenesis, 8, 35-41.
234. Miller MS, Buck SH, Brendel K et al. (1980). Dihydrocapsaicin-induced hypothermia and substance P depletion in rats. Pharmacologist, 22, 206.
235. Miller MS, Buck SH, Schnellmann R et al. (1981). Substance P depletion and analgesia induced by capsaicin analogs in guinea pigs. Fed Proc, 40, 274.
236. Ministry of Defence (1972). Medical Manual of Defence Against Chemical Agents. London, UK: Her Majesty's Stationary Office.
237. MishraPK (1984). Role of smokes inwarfare. Defence Sci J, 44, 173-179.
238. Monsereenusorn Y (1983). Subchronic toxicity studies of capsaicin and capsicum in rats. Res Commun Chem Path Pharmacol, 41, 95-110.
239. Montell C, Birnbaumer L, Flockerzi V et al. (2002). A unified nomenclature for the superfamily of TRP cation-channels. Mol Cell, 9, 229-231.
240. Morby P, Murray V, Cummins A et al. (2000). The capability of accident and emergency departments to safely decontaminate victims of chemical incidents. J Accid Emerg Med, 17, 344-347.
241. Morice AH, Higgns KS and Yeo WW (1992). Adaptation of cough reflex with different types of stimulation. Eur Resp J, 5, 841-847.
242. Nagabhushan M and Bhide SV (1985). Mutagenicity of chilli extract and capsaicin in short term tests. Environ Mutagen, 7, 881-888.
243. Narasimhamurthy M and Narasimhamurthy K (1988). Non-mutagencity of capsaicin in albino mice. Food Chem Toxicol, 26, 955-958.
244. National Institute of Justice (1994). Oleoresin capsicum: pepper spray as a force alternative. NIJ, Technology Assessment Program. Washington, DC, USA: US Department of Justice, Office of Justice Programs, National Institute of Justice.
245. Niesink RJM, De Vries J and Holliger MA (1996). Toxicology. Principles and Applications. Boca Raton, FL, USA: CRC Press.
246. Noeller TP (2001). Biological and chemical terrorism: recognition and management. Cleveland Clinic J Med, 68, 1001-1006.
247. NRC (1999). Chemical and Biological Terrorism. Washington DC, USA: National Research Council, National Academy Press.
248. NTP (1990a). Toxicology and carcinogenesis studies of 2-chloroacetophenone (CAS No. 532-27-4) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program, Technical Report 379. Research Triangle Park, NC, USA: National Toxicology Program.
249. NTP (1990b). Toxicology and carcinogenesis studies of CS2 (4% o-chlorobenzalmalononitrile) (CAS No. 2698-41-1) in F334/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program, Technical Report 377. Research Triangle Park, NC, USA: National Toxicology Program.
250. Nusse M, Recknagel S and Beisker W (1992). Micronuclei induced by 2-chlorobenzylidene malononitrile contain single chromosomes as demonstrated by the combined use of flow cytometry and immunofluorescent staining with anti-kinetochore antibodies. Mutagenesis, 7, 57-67.
251. Oaks IW, Dorman JE and Petty RW (1969). Tear gas burns of the eye. Arch Opthalmol, 63, 698-706.
252. OiY, Kawada T,Watanabe T et al. (1992). Induction of capsaicin-hydrolyzing enzyme activity in rat liver by continuous oral administration of capsaicin. J Agr Food Chem, 40, 467-470.
253. Oksala A and Salminen I (1975). Eye injuries caused by tear-gas hand weapons. Arch Ophthalmol, 63, 908-913.
254. Okumura T, Suzuki K, Fukuda A et al. (1998). The Tokyo subway sarin attack: Disaster management, Part 2: Hospital response. Acad EmergMed, 5, 618-624.
255. Olajos EJ (2004). Biochemistry, biological interactions, and pharmacokinetics of riot control agents. In: Riot Control Agents. Issues in Toxicology, Safety and Health (EJ Olajos and W Stopford, eds), pp. 37-63. Boca Raton, FL, USA: CRC Press.
256. Olajos EJ and Lakoski JM (2004). Pharmacology/toxicology of oleoresin capsicum, capsaicin, and capsaicinoids. In: Riot Control Agents. Issues in Toxicology, Safety and Health (EJ Olajos and W Stopford, eds), pp. 123-143. Boca Raton, FL, USA: CRC Press.
257. Olajos EJ and Salem H (2001). Riot control agents: pharmacology, toxicology, biochemistry and chemistry. J Appl Toxicol, 21, 355-391.
258. Olajos EJ and Stopford W (2004). Introduction and historical perspective. In: Riot Control Agents. Issues in Toxicology, Safety and Health (EJ Olajos and W Stopford, eds), pp. 1-24. Boca Raton, FL, USA: CRC Press.
259. Osborne JS, Adamek S and Hobbs ME (1956). Some components of gas phase of cigarette smoke. Anal Chem, 28, 211-215.
260. Owens EJ and Punte CL (1963). Human respiratory and ocular irritation studies utilizing o-chlorobenzylidene malononitrile aerosols. Am Indust Hyg Assoc J, 24, 262-264.
261. Park S and Giammona ST (1972). Toxic effects of tear gas on an infant following prolonged exposure. Am J Dis Childhood, 123, 245-246.
262. Pearlman AI (1969). Nonlethal weapons for use by law enforcement agencies. New Physic, (August), 625-628.
263. Penneys NS (1971). Contact dermatitis due to chloroacetophenone. Fed Proc, 30, 96-99.
264. Penneys NS, IsrealRMand IndginSM (1969) Contact dermatitis due to 1-choroacetophenone and chemical mace. New England J Med,, 281, 413-415.
265. Pfeiff B (1984). Allergic contact dermatitis to chloroacetophenone (mace). Z Hautkr, 60, 178-184.
266. Philip G, Baroody FM, Proud D et al. (1994). The human nasal response to capsaicin. J Allergy Clin Immunol, 94, 1035-1045.
267. Punte CL, Ballard TA andWeimer JT (1962a). Inhalation studies with chloroacetophenone, diphenylaminochloroarsine and pelargonic morpholide. 1. Animal exposures. Ind Hyg J, 23, 194-198.
268. Punte CL,Weimer JT, Ballard TA et al. (1962b). Toxicologic studies on o-chlorobenzylidene malononitrile. Toxicol Appl Pharmacol, 4, 656-662.
269. Punte CL, Owens EJ and Gutentag PJ (1963). Exposure to ortho-chlorobenzylidene malononitrile. Arch Environ Health, 6, 366-374.
270. Queen FB and Stander T (1941). Allergic contact dermatitis following exposure to tear gas (chloroacetophenone, CN). J Am Med Assoc, 117, 1879.
271. Rappert B (2003). Health and safety in policing: lessons from the regulation of CS sprays in the UK. Soc Sci Med, 56, 1269-1278.
272. Reay DT, Fligner CI, Stilwell AD et al. (1992). Positional asphyxia during law enforcement transport. Am J Forens Med Pathol, 13, 90-97.
273. Reilly CA, Crouch DJ, Yost GS et al. (2001). Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. J Chromatogr A, 912, 259-267.
274. Reilly CA, Crouch DJ, Yost GS et al. (2002a). Detection of pepper spray residues on fabrics using liquid chromatography-mass spectrometry. J Forens Sci, 47, 37-43.
275. Reilly CA, Crouch DJ, Yost GS et al. (2002b). Determination of capsaicin, nonivamide and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry. J Anal Toxicol, 26, 313-319.
276. Reilly CA, Ehlhardt WJ, Jackson DA et al. (2003). Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol, 16, 336-349.
277. Reitveld EC, Delbressine LPC,Waegemaekers THJM et al. (1983). 2-Chlorobenzylmercapturic acid, a metabolite of the riot control agent 2-chlorobenzylidene malononitrile (CS) in the rat. Arch Toxicol, 54, 139-144.
278. Rengstorff RH (1969a). Tear gas and riot control agents: a review of eye effects. Optomet Weekly, 60, 25-28.
279. Rengstorff RH (1969b). The effect of the riot control agent CS on visual acuity. Mil Med, 134, 219-221.
280. Rengstorff RH and Mershon MM (1969). CS in water: effects on human eyes. Edgewood Arsenal Technical Report Series, Number 4377, dated December 1969. Edgewood Arsenal, MD, USA: Department of the Army.
281. Rengstorff RH and MershonMM (1971) CS in water. II. Effects on human eyes. Mil Med,, 136, 149-151.
282. Rengstorff RH, Petrali JP, MershonMMet al. (1975). The effect of the riot control agent dibenz(b.f)-1,4-oxazepine (CR) in the rabbit eye. Toxicol Appl Pharmacol, 34, 45-48.
283. Rioux JP and Myers RA (1988). Methylene chloride poisoning: a pragmatic review. J Emerg Med, 6, 227-238.
284. Rioux JP and Myers RA (1989). Hyperbaric oxygen for methylene chloride poisoning: report of two cases. Annu Emerg Med, 18, 691-695.
285. Rose I (1969). Mace-a dangerous police weapon. Ophthalmologia, 158, 448-454.
286. Rothberg S (1970). Skin sensitizing potential of the riot control control agents BBC, DM, CN and CS in guinea pigs. Mil Med, 135, 552-556.
287. Salem H, Olajos EJ and Katz SA (2001). Riot control agents. In: Chemical Warfare Agents: Toxicity at Low Levels (SM Somani and JA Romano Jr, eds), pp. 321-372. Boca Raton, FL, USA: CRC Press.
288. Salem H, Ballantyne B and Katz SA (2005a). Riot control agents. In: Encyclopedia of Toxicology, Second Edition (PWexler, ed.), pp. 706-723. Oxford, UK: Elsevier.
289. Salem H, Ballantyne B and Katz SA (2005b). Arsenical vomiting agents. In: Encyclopedia of Toxicology, Second Edition (P Wexler, ed.) pp.171-173. Oxford, UK: Elsevier.
290. Salem H, Ballantyne B and Katz SA (2005c). Inhalation toxicology of riot control agents. In: Inhalation Toxicology, Second Edition. (H Salem and SA Katz, eds), pp. 485-528. Boca Raton, FL, USA: CRC Press.
291. Salem H, Ballantyne B and Katz SA (2005d). CN. In: Encyclopedia of Toxicology, Second Edition. (P Wexler, ed.), pp. 626-628. Oxford, UK: Elsevier.
292. Salem H, Ballantyne B and Katz SA (2005e). CS. In: Encyclopedia of Toxicology, Second Edition (P Wexler, ed.), pp. 686-690. Oxford, UK: Elsevier.
293. Sallasidis K, Schmid E and Bauchinger M (1991). Mitotic spindle damage induced by 2-chlorobenzylidene malononitrile (CS) in V79 Chinese hamster cells examined by different staining of the spindle apparatus and chromosomes. Mutat Res, 262, 263-266.
294. Sanico AM, Atsuta S, Proud D et al. (1997). Dosedependent effects of capsaicin nasal challenge: in vivo evidence of human airway neurogenic inflammation. J Allery Clin Immunol, 100, 632-641.
295. Sanford, J.P. (1976). Medical aspects of riot control (harassing) agents. Ann Rev Med, 77, 412-429.
296. Sasajimi K, Willey JC, Banks-Schlegel SP et al. (1987). Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured cells of human esophageal epithelial cells. J Nat Cancer Inst, 78, 419-458.
297. Schmid E and Bauchinger M (1991). Analysis of the aneuploidy inducing capacity of 2-chlorobenzylidene malononitrile (CS) and metabolites in V79 Chinese hamster cells. Mutagenesis, 6, 303-305.
298. Schmid E, Bauchiner M, Ziegler-Skylakakis K et al. (1989). 2-Chlorobenzylidene malononitrile (CS) causes spindle disturbances in V79 Chinese hamster cells. Mut Res, 226, 133-136.
299. Schmunes E and Taylor JS (1973). Industrial contact dermatitis. Effect of the riot control agent orthochlorobenzylidene malononitrile. Arch Dermatol, 107, 212-216.
300. Schwartz L, Tulipan L and Birmingham DJ (1957). Occupational Diseases of the Skin. Philadelphia, PA, USA: Lea and Febiger.
301. Security Planning Corporation (1972). Nonlethal weapons for law enforcement, research needs and priorities. A Report to the National Science Foundation, Washington, DC, USA.
302. Shreenivason V and Boese BA (1970). Identification of lachrymators. J Forens Sci, 15, 433-442.
303. Sidell FR (1997). Riot control agents. In: Textbook of Military Medicine. Medical Aspects of Chemical and Biological warfare (FR Sidell, ET Takefuji and DR Frantz, eds), Chapter 12, pp. 307-324. Washington, DC, USA: Office of the Surgeon General, US Army. TMM Publications, Borden Institute.
304. SIPRI (1971). Stockholm International Peace Research Institute. Problems of Chemical and Biological Warfare. A Study of Historical, Technical, Military and Legal and Political Aspects of CBW, Volume 1, The Rise of CB Weapons; Volume 10, Humanities. Stockholm, Sweden: SIPRI.
305. Smialek JE, Ratanoproeska O and Spitz WV (1975). Accidental death with a tear-gas pen gun: a case report. J Forens Sci, 20, 709-713.
306. Smith CG and Stopford W (1999). Health hazards of pepper spray. N Carolina Med J, 60, 268-274.
307. Smith PA, Kluchinsky TA, Savage PB et al. (2002). Traditional sampling with laboratory analysis and solid phase microextraction sampling with field gas chromatograph/mass spectrometry by military industrial hygienists. Am Ind Hyg Assoc J, 63, 284-292.
308. Stahl CJ and Davis JH (1969). Missile wounds caused by tear gas Pen guns. Am J Clin Pathol, 52, 270-276.
309. Stahl CJ, Young BC, Brown RJ et al. (1968). Forensic aspects of tear-gas pen guns. J Forens Sci, 13, 442-469.
310. Stefee CH, Lantz PA, Flannagan LM et al. (1995). Oleoresin capsicum (pepper) spray and 'in custody deaths'. Am J Forens Med Pathol, 16, 185-192.
311. Stein AA and Kirwin WE (1964). Chloroacetophenone (tear gas) poisoning: a clinico-pathological report. J Forens Sci, 9, 374-382.
312. Stjarne P (1991). Sensory and reflex control of nasal mucosal blood flow and secretion: clinical implications in non-allergenic nasal hyperreactivity. Acta Physiol Scand, 142 (Supplement 600), 1-64.
313. Sun JD, Henderson RF, Marshall TC et al. (1987). The inhalation toxicity of two commercial dyes: solvent yellow 33 and solvent green 3. Fund Appl Toxicol, 8, 358-371.
314. Surh Y-J and Lee SS (1995). Capsaicin, a doubleedged sword: toxicity, metabolism and chemopreventive potential. Life Sci, 56, 1845-1855.
315. SurhY-H, Ahn SH, Kim K-C et al. (1995). Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications. Life Sci, 56, 305-311.
316. Swearengen TR (1966). Tear-Gas Munitions. Springfield, VA: USA: Thomas.
317. Swentzel KC, Merkey RP, Cucinell SA et al. (1970). Unchanged thiocyanate levels in human subjects following exposure to CS aerosol. Edgewood Arsenal Technical Memorandum, Number 100-8, dated June 1970. Edgewood Arsenal, MA, USA: Department of the Army.
318. SzallasiAand Blumberg PM(1990a). Specific binding resiniferatoxin, an ultra-potent capsaicin analog by dorsal root ganglion membranes. Brain Res, 524, 106-111.
319. SzallasiAand Blumberg PM(1990b). Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci, 47, 1399-1408.
320. Szallasi A and Blumberg PM (1999). Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev, 51, 159-212.
321. Szallasi A, Szolcsanyi J, Szallasi Z et al. (1991). Inhibtion of [3H] resiniferatoxin binding to dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity. Naunyn-Schmiedeberg's Arch Pharmacol, 344, 551-556.
322. Takafuji ET and Kok AB (1997). The chemical warfare threat and the military health care provider. In: Textbook of Military Medicine. Medical Aspects of Chemical and Biological Warfare. (FR Sidell, ET Takefuji and DR Frantz, eds), Chapter 4, pp. 86-94. Washington, DC, USA: Office of the Surgeon Generral, US Army. TMM Publications, Borden Institute.
323. The Observer (1969). 60 babies ill from riot gas. The Observer (London), dated 24 August, p. 1.
324. The Times (1969). Defence ministry concern at Ulster riot gas. The Times (London), dated 26 August, p. 1.
325. Thornburn KM (1982). Injuries after the use of the lachrymatory agent chloroacetophenone in a confined space. Arch Environ Health, 37, 182-186.
326. Toth B, Rogan E and Walker B (1984). Tumorigenicity and mutagenicity studies with capsaicin of hot peppers. Anticancer Res, 4, 117-119.
327. Trigwell P (1997). CS gas has been used as a chemical restraint in a mentally ill person. Br Med J, 314, 444.
328. United Nations (1969). Chemical and Bacteriological (Biological) Weapons and the Effects of their Possible Use, Report of the Secretary General, Annexe 111. New York, NY, USA: United Nations.
329. Upshall DG (1973). Effects of o-chlorobenzylidene malononitrile (CS) and the stress of aerosol inhalation upon rat and rabbit embryonic development. Toxicol Appl Pharmacol, 24, 45-59.
330. Upshall DG (1974). The effects of dibenz(b.f)-1:4-oxazepine (CR) upon rat and rabbit embryonic development. Toxicol Appl Pharmacol, 24, 301-311.
331. Upshall DG (1977a). Embryonic development and inhalation stress. In: Current Approaches in Toxicology (B Ballantyne, ed.), pp. 79-85. Bristol, UK: John Wright.
332. Upshall DG (1977b). Riot control smokes: lung absorption and metabolism of peripheral sensory irritants. In: Clinical Toxicology (W Duncan and BJ Leonard, eds), pp. 121-129. Amsterdam, The Netherlands: Excerpta Medica.
333. USA Today (2003). Chicago club may loose its licenses. USA Today, dated 20 February, Section A, p. 4.
334. Vaca FE, Myers JH and Langdorf M (1996). Delayed pulmonary edema and bronchospasm after accidental lacrimator exposure. Am J Emerg Med, 14, 402-405.
335. Varma S and Holt PJ (2001). Severe cutaneous reaction to CS gas. Clin Exp Dermatol, 26, 248-250.
336. Vesaluoma M,Müller J, Lambiase A et al. (2000). Effects of oleoresin capsicum pepper spray on human corneal morphology and sensitivity. Invest Ophthalmol Visual Sci, 41, 2138-2147.
337. Villesansor IM and de Campo EJ (1994). Clastogenicity of red pepper (Capsicum frutescens L.) extracts. Mutat Res, 312, 151-155.
338. Von Daniken A, Frederich U, Lutz W et al. (1981). Tests for mutagenicity in Salmonella and covalent binding toDNAand protein in the rat of the riot control agent o-chlorobenzylidene malononitrile (CS). Arch Toxicol, 49, 15-27.
339. WatsonWA, StremelKRandWestdorp EJ (1996). Oleoresin capsicum (Cap-Stun) toxicity from aerosol exposure. Ann Pharmacotherap, 30, 733-735.
340. Wehmeyer KR, Kasting GB, Powell JH et al. (1990). Application of liquid chromatography with on-line radiochemical detection to metabolism studies on a novel class of analgesics. J Pharmaceut Biomed Anal, 8, 177-183.
341. Weigand DA (1969). Cutaneous reaction to the riot control agent CS. Mil Med, 134, 437-440.
342. Weigand DA and Mershon MM(1970). Cutaneous reaction to EA 3547 in propylene glycol. Edgewood Arsenal Technical Report, Number 4413, dated December 1970. Edgewood Arsenal, Bethesda, MA, USA: Department of the Army.
343. Weit E (2001). The health impact of crowd-control agents. Canad Med Assoc J, 164, 1889.
344. Weller EM, Kubbies M and Nusse M (1995). Induction of cell cycle perturbations by tear gas 2-chlorobenzylidene malononitrile (CS) in synchronously and asynchronously proliferating mammalian cells. Cytometry, 19, 334-342.
345. White House (1994). Riot control agents. Press Release, dated 23 June. Washington, DC, USA: Office of the Press Secretary, White House.
346. WHO (1970). Health Aspects of Chemical and Biological Weapons. Geneva, Switzerland: World Health Organization.
347. Wier E (2001). The health impact of crowd-control agents. Can Med Assoc J, 164, 1889.
348. Wild D, Eckhardt K, Harnasch D et al. (1983). Genotoxicity study of CS (ortho-chlorobenzylidene malononitrile) in Salmonella, Drosophila and mice. Arch Toxicol, 54, 167-170.
349. Witten B, Wagman W, Saffer R et al. (1970). Malodorous substances as riot control and training agents. Edgewood ArsenalTechnical Report, Number 4370, dated 00000 1970. Edgewood Arsenal, MA, USA: Department of the Army.
350. Wood JN,Winter J, James IF et al. (1988). Capsaicininduced ion fluxes in dorsal root ganglion cells in culture. J Neurosci, 8, 320-322.
351. Worthington E and Nee PA (1999). CS exposure-clinical effects and management. J Accid Emerg Med, 16, 168-179.
352. Yih P-H (1995). CS gas injury to the eye. Br Med J, 311, 276.
353. Zeiger E, Anderson B, Howorth S et al. (1987). Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals. Environ Mutagen, 9, 1-109.
354. Zerba EN and Ruveda MA (1972). Gas chromatographic determination of riot control agents. J Chromatogr Anal, 68, 245-247.
355. Ziegler-Skylakakis K, Summer KH and Andrae U (1989). Mutagenicity and cytotoxicity of 2-chlorobenzylidene malononitrile (CS) and its metabolites in V79 Chinese hamster cells. Arch Toxicol, 63, 314-319.