Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system

Biomaterials

Volumn 35, Issue 6, 2014, Pages 1989-2000

  Zhang, Shanshan ^a   Anderson, Mark A ^b   Ao, Yan ^b   Khakh, Baljit S ^b   Fan, Jessica ^c   Deming, Timothy J ^a,c   Sofroniew, Michael V ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

Anti cancer drugs; Brain; Hydrogels; Neural stem cells; Reactive astrocytes; Spinal cord

Indexed keywords

AMINO ACIDS; BRAIN; DISEASES; GENE EXPRESSION; HYDROGELS; HYDROPHOBICITY; MAMMALS; MOLECULES; NEUROPHYSIOLOGY; STEM CELLS; TARGETED DRUG DELIVERY;

AMINO ACID COMPOSITIONS; ANTICANCER DRUG; CENTRAL NERVOUS SYSTEMS; HYDROPHOBIC MOLECULES; NEURAL STEM CELL; REACTIVE ASTROCYTES; REPORTER-GENE EXPRESSION; SPINAL CORDS;

CONTROLLED DRUG DELIVERY;

ALANINE; CHOLESTEROL; TAMOXIFEN; TEMOZOLOMIDE;

AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIBLOCK COPOLYPEPTIDE HYDROGEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; GENE EXPRESSION; HYDROGEL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVOUS SYSTEM INJURY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; RIGIDITY; VISCOSITY;

MUS MUSCULUS;

ANTI-CANCER DRUGS; BRAIN; HYDROGELS; NEURAL STEM CELLS; REACTIVE ASTROCYTES; SPINAL CORD;

ANIMALS; CENTRAL NERVOUS SYSTEM; CHOLESTEROL; DRUG DELIVERY SYSTEMS; HYDROGEL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, TRANSGENIC; MODELS, THEORETICAL; PEPTIDES; TAMOXIFEN;

EID: 84890178483     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.11.005     Document Type: Article

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