Late gestation over- and undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs

Acta Physiologica

Volumn 210, Issue 1, 2014, Pages 110-126

  Khanal, P ^a   Husted, S V ^a   Axel, A M D ^a   Johnsen, L ^a   Pedersen, K L ^a   Mortensen, M S ^a   Kongsted, A H ^a   Nielsen, M O ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fat deposition; Foetal malnutrition; Metabolic profiles; Obesity; Post natal overnutrition

Indexed keywords

3 HYDROXYBUTYRIC ACID; CHOLESTEROL; CREATININE; FATTY ACID; GHRELIN; GLUCOSE; HYDROCORTISONE; INSULIN; LACTIC ACID; LEPTIN; SOMATOMEDIN C; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET RESTRICTION; ENDOCRINE FUNCTION; EWE; FEMALE; FOOD INTAKE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; INSULIN SENSITIVITY; LACTATE BLOOD LEVEL; LIPID DIET; LIPID STORAGE; MALNUTRITION; MATERNAL NUTRITION; METABOLIC SYNDROME X; METABOLISM; NONHUMAN; NUTRIENT SUPPLY; OUTCOME ASSESSMENT; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN INTAKE; PUBERTY; SUBCUTANEOUS FAT; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

FAT DEPOSITION; FOETAL MALNUTRITION; METABOLIC PROFILES; OBESITY; POST-NATAL OVERNUTRITION;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; FASTING; FEMALE; FETAL NUTRITION DISORDERS; GESTATIONAL AGE; GLUCOSE; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; OVERNUTRITION; PREGNANCY; SHEEP;

EID: 84890165759     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12129     Document Type: Article

References (37)

1. Abbott, W.G. & Foley, J.E. 1987. Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children. Metabolism 36, 576-579.
2. Beausoleil, N.J., Blache, D., Stafford, K.J., Mellor, D.J. & Noble, A.D.L. 2008. Exploring the basis of divergent selection for 'temperament' in domestic sheep. Appl Anim Behav Sci 109, 261-274.
3. Blache, D., Tellam, R.L., Chagas, L.M., Blackberry, M.A., Vercoe, P.E. & Martin, G.B. 2000. Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep. J Endocrinol 165, 625-637.
4. Bouchard, C., Despres, J.P. & Mauriege, P. 1993. Genetic and nongenetic determinants of regional fat distribution. Endocr Rev 14, 72-93.
5. Breier, B.H., Gallaher, B.W. & Gluckman, P.D. 1991. Radioimmunoassay for insulin-like growth factor-I: solutions to some potential problems and pitfalls. J Endocrinol 128, 347-357.
6. Cerf, M.E. 2007. High fat diet modulation of glucose sensing in the beta-cell. Med Sci Monit 13, RA12-RA17.
7. Chen, J., Muntner, P., Hamm, L.L., Jones, D.W., Batuman, V., Fonseca, V., Whelton, P.K. & He, J. 2004. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140, 167-174.
8. Curhan, G.C., Chertow, G.M., Willett, W.C., Spiegelman, D., Colditz, G.A., Manson, J.E., Speizer, F.E. & Stampfer, M.J. 1996. Birth weight and adult hypertension and obesity in women. Circulation 94, 1310-1315.
9. Despres, J.P. & Lemieux, I. 2006. Abdominal obesity and metabolic syndrome. Nature 444, 881-887.
10. Dyer, J.S. & Rosenfeld, C.R. 2011. Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: a review. Semin Reprod Med 29, 266-276.
11. Ford, S.P. & Long, N.M. 2011. Evidence for similar changes in offspring phenotype following either maternal undernutrition or overnutrition: potential impact on fetal epigenetic mechanisms. Reprod Fertil Dev 24, 105-111.
12. Ford, S.P., Hess, B.W., Schwope, M.M., Nijland, M.J., Gilbert, J.S., Vonnahme, K.A., Means, W.J., Han, H. & Nathanielsz, P.W. 2007. Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring. J Anim Sci 85, 1285-1294.
13. Godfrey, K.M. & Barker, D.J. 2000. Fetal nutrition and adult disease. Am J Clin Nutr 71, 1344S-1352S.
14. Grattan, D.R. 2008. Fetal programming from maternal obesity: eating too much for two? Endocrinology 149, 5345-5347.
15. Guilloteau, P., Zabielski, R., Hammon, H.M. & Metges, C.C. 2009. Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments. J Physiol Pharmacol 60, 17-35.
16. Hales, C.N. & Barker, D.J. 1992. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601.
17. Husted, S.M., Nielsen, M.O., Tygesen, M.P., Kiani, A., Blache, D. & Ingvartsen, K.L. 2007. Programming of intermediate metabolism in young lambs affected by late gestational maternal undernourishment. Am J Physiol Endocrinol Metab 293, E548-E557.
18. Kahn, S.E., Hull, R.L. & Utzschneider, K.M. 2006. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444, 840-846.
19. Kongsted, A.H., Tygesen, M.P., Husted, S.V., Oliver, M.H., Tolver, A., Christensen, V.G., Nielsen, J.H. & Nielsen, M.O. 2013. Programming of the glucose-insulin homeostasis: long-term consequences of prenatal versus early postnatal nutrition insults. Evidence from a sheep model. Acta Physiol, doi: 10.1111/apha.12080 [early view].
20. Lamacchia, O., Nicastro, V., Camarchio, D., Valente, U., Grisorio, R., Gesualdo, L. & Cignarelli, M. 2011. Para- and perirenal fat thickness is an independent predictor of chronic kidney disease, increased renal resistance index and hyperuricaemia in type-2 diabetic patients. Nephrol Dial Transplant 26, 892-898.
21. Lemieux, I. 2004. Energy partitioning in gluteal-femoral fat: does the metabolic fate of triglycerides affect coronary heart disease risk? Arterioscler Thromb Vasc Biol 24, 795-797.
22. Lupi, R., Dotta, F., Marselli, L., Del Guerra, S., Masini, M., Santangelo, C., Patane, G., Boggi, U., Piro, S., Anello, M., Bergamini, E., Mosca, F., Di Mario, U., Del Prato, S. & Marchetti, P. 2002. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51, 1437-1442.
23. Miller, D.R., Jackson, R.B., Blache, D. & Roche, J.R. 2009. Metabolic maturity at birth and neonate lamb survival and growth: the effects of maternal low-dose dexamethasone treatment. J Anim Sci 87, 3167-3178.
24. Miranda, P.J., DeFronzo, R.A., Califf, R.M. & Guyton, J.R. 2005. Metabolic syndrome: definition, pathophysiology, and mechanisms. Am Heart J 149, 33-45.
25. Misra, A., Garg, A., Abate, N., Peshock, R.M., Stray-Gundersen, J. & Grundy, S.M. 1997. Relationship of anterior and posterior subcutaneous abdominal fat to insulin sensitivity in nondiabetic men. Obes Res 5, 93-99.
26. Muhlhausler, B.S., Adam, C.L., Findlay, P.A., Duffield, J.A. & McMillen, I.C. 2006. Increased maternal nutrition alters development of the appetite-regulating network in the brain. FASEB J 20, 1257-1259.
27. Nielsen, M.O., Kongsted, A.H., Thygesen, M.P., Strathe, A.B., Caddy, S., Quistorff, B., Jorgensen, W., Christensen, V.G., Husted, S., Chwalibog, A., Sejrsen, K., Purup, S., Svalastoga, E., McEvoy, F.J. & Johnsen, L. 2012. Late gestation undernutrition can predispose for visceral adiposity by altering fat distribution patterns and increasing the preference for a high-fat diet in early postnatal life. Br J Nutr, 109, 2098-2110.
28. NRC 2007. Nutrient Requirements for Small Ruminants. The National Academies Press, Washington, DC.
29. Okura, T., Nakata, Y., Yamabuki, K. & Tanaka, K. 2004. Regional body composition changes exhibit opposing effects on coronary heart disease risk factors. Arterioscler Thromb Vasc Biol 24, 923-929.
30. Patel, M.S. & Srinivasan, M. 2011. Metabolic programming in the immediate postnatal life. Ann Nutr Metab 58, 18-28.
31. Perrone, R.D., Madias, N.E. & Levey, A.S. 1992. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 38, 1933-1953.
32. Ravelli, A.C., van Der Meulen, J.H., Osmond, C., Barker, D.J. & Bleker, O.P. 1999. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr 70, 811-816.
33. Snijder, M.B., Dekker, J.M., Visser, M., Bouter, L.M., Stehouwer, C.D., Kostense, P.J., Yudkin, J.S., Heine, R.J., Nijpels, G. & Seidell, J.C. 2003. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study. Am J Clin Nutr 77, 1192-1197.
34. Symonds, M.E. & Lomax, M.A. 1992. Maternal and environmental influences on thermoregulation in the neonate. Proc Nutr Soc 51, 165-172.
35. Tran, T.T., Yamamoto, Y., Gesta, S. & Kahn, C.R. 2008. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 7, 410-420.
36. Unger, R.H. & Orci, L. 2001. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 15, 312-321.
37. Wajchenberg, B.L. 2000. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21, 697-738.