Prevention of inappropriate prescribing in hospitalized older patients using a computerized prescription support system (intercheck®)

Drugs and Aging

Volumn 30, Issue 10, 2013, Pages 821-828

  Ghibelli, Simona ^a   Marengoni, Alessandra ^a   Djade, Codjo D ^b   Nobili, Alessandro ^b   Tettamanti, Mauro ^b   Franchi, Carlotta ^b   Caccia, Silvio ^b   Giovarruscio, Flavio ^b   Remuzzi, Andrea ^b   Pasina, Luca ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPRAZOLAM; AMIODARONE; AMLODIPINE; ATENOLOL; BENZODIAZEPINE DERIVATIVE; CANRENONE; CARBAMAZEPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; CLOPIDOGREL; DIGOXIN; DILTIAZEM; DOXAZOSIN; FUROSEMIDE; HALOPERIDOL; LORAZEPAM; OXAZEPAM; PAROXETINE; PREDNISONE; PROMAZINE; RAMIPRIL; SIMVASTATIN; TEMAZEPAM; TICLOPIDINE; TRIAZOLAM; WARFARIN; ZOLPIDEM;

AGED; ANTICHOLINERGIC EFFECT; ARTICLE; COMPUTER PROGRAM; COMPUTER SYSTEM; ELECTRONIC PRESCRIBING; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HUMAN; INAPPROPRIATE PRESCRIBING; ITALY; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREVENTION STUDY; PRIORITY JOURNAL; RISK ASSESSMENT;

AGED; AGED, 80 AND OVER; CHOLINERGIC ANTAGONISTS; DRUG INTERACTIONS; DRUG THERAPY, COMPUTER-ASSISTED; FEMALE; GERIATRICS; HOSPITALIZATION; HUMANS; INAPPROPRIATE PRESCRIBING; MALE;

EID: 84890138121     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-013-0109-5     Document Type: Article

References (59)

1. Veehof LJG, Stewart RE, Haaijer-Raskamp FM, et al. The development of polypharmacy. A longitudinal study. Fam Pract. 2000;17:261-7. (Pubitemid 30386721)
2. Gurwitz JH. Polypharmacy. A new paradigm for quality drug therapy in the elderly? Arch Intern Med. 2004;164:1957-9. (Pubitemid 39390550)
3. Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5:345-51.
4. Lin CF, Wang CY, Bai CH. Polypharmacy, aging and potential drug-drug interactions in outpatients in Taiwan. Drugs Aging. 2011;28(3):219-25.
5. Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85:86-98.
6. Steinman MA, Landefeld CS, Rosenthal GE, et al. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc. 2006;54:1516-23. (Pubitemid 44564145)
7. Koh Y, Kutty FBM, Li SC. Drug-related problems in hospitalized patients on polypharmacy: the influence of age and gender. Ther Clin Risk Manag. 2005;1:39-48.
8. Lund BC, Camahan RM, Egge JA, et al. Inappropriate prescribing predicts adverse drug events in older adults. Ann Pharmacother. 2010. doi: 10.1345/aph.1M657.
9. Nobili A, Garattini S, Mannucci PM. Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium. J Comorbidity. 2011;1:28-44.
10. Cruciol-Souza JM, Thomson JC. Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital. J Pharm Pharm Sci. 2006;9:427-33. (Pubitemid 46630111)
11. Radosevic N, Gantumur M, Vlahovic-Palcevski V. Potentially inappropriate prescribing to hospitalised patients. Pharmacoepidemiol Drug Saf. 2008;17:733-7.
12. O'Connor MN, Gallagher P, O'Mahony D. Inappropriate prescribing: criteria, detection and prevention. Drugs Aging. 2012;29(6):437-52.
13. Chang CB, Chan DC. Comparison of published explicit criteria for potentially inappropriate medications in older adults. Drugs Aging. 2010;27(12):947-57.
14. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163(22):2716-24. (Pubitemid 37517412)
15. Flacker JM, Cummings V, Mach JR Jr, et al. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry. 1998;6(1):31-41. (Pubitemid 28051719)
16. Tune LE. Anticholinergic effects of medication in elderly patients. J Clin Psychiatry. 2001;62(suppl 21):11-4. (Pubitemid 32937572)
17. Hanlon JT, Schamder KE, Boult C, et al. Use of inappropriate prescription drugs by older people. J Am Geriatr Soc. 2002;50:26-34. (Pubitemid 34053019)
18. Campbell NL, Boustani MA, Lane KA, et al. Use of anticholinergics and the risk of cognitive impairment in an African American population. Neurology. 2010;75:152-9.
19. Carriere I, Fourrier-Reglat A, Dartigues JF, et al. Drugs with anticholinergic properties, cognitive decline, dementia in an elderly general population-the 3-City study. Arch Intern Med. 2009;169:1317-24.
20. Lechevallier-Michel N, Molimard M, Dartigues JF, et al. Drugs with anticholinergic properties and cognitive performance in the elderly: results from the PAQUID study. Br J Clin Pharmacol. 2005;59(2):143-51. (Pubitemid 40208849)
21. Roe CM, Anderson MJ, Spivack B. Use of anticholinergic medications by older adults with dementia. J Am Geriatr Soc. 2002;50(5):836-42. (Pubitemid 34496679)
22. Han L, McCusker J, Cole M, et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med. 2001;161(8):1099-105. (Pubitemid 32685536)
23. Moore AR, O'Keeffe ST. Drug-induced cognitive impairment in the elderly. Drugs Aging. 1999;15(1):15-28. (Pubitemid 29358484)
24. Aizenberg D, Sigler M, Weizman A, et al. Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study. Int Psychogeriatr. 2002;14(3):307-10. (Pubitemid 35375545)
25. Ancelin ML, Artero S, Portet F, et al. Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. BMJ. 2006;332(7539):455-9. (Pubitemid 43342043)
26. Landi F, Russo A, Liperoti R, et al. Anticholinergic drugs and physical function among frail elderly population. Clin Pharmacol Ther. 2007;81(2):235-41. (Pubitemid 46174821)
27. Atkin PA, Veitch PC, Veitch EM, et al. The epidemiology of serious adverse drug reactions among the elderly. Drugs Aging. 1999;14(2):141-52. (Pubitemid 29086114)
28. Hutchinson TA, Flegel KM, Kramer MS, et al. Frequency, severity and risk factors for adverse drug reactions in adult out-patients: a prospective study. J Chron Dis. 1986;39(7):533-42.
29. Pasina L, Djade CD, Lucca U, et al. Association of anticholinergic burden with cognitive and functional status in a cohort of hospitalized elderly: comparison of the anticholinergic cognitive burden scale and anticholinergic risk scale. Drugs Aging. 2012. doi: 10.1007/s40266-012-0044-x.
30. Hines LE, Murphy JE. Potentially harmful drug-drug interactions in the elderly: a review. Am J Geriatr Pharmacother. 2011;9(6):364-77.
31. Bowie MW, Slattum PW. Pharmacodynamics in older adults: a review. Am J Geriatr Pharmacother. 2007;5:263-303. (Pubitemid 350048507)
32. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet. 2007;370:185-91. (Pubitemid 47042897)
33. Bjorkman IK, Fastbom J, Schmidt IK, et al. Drug-drug interactions in the elderly. Ann Pharmacother. 2002;36:1675-81. (Pubitemid 35265600)
34. Becker ML, Kallewaard M, Caspers PW, et al. Hospitalisations and emergency department visits due to drug-drug interactions: a literature review. Pharmacoepidemiol Drug Saf. 2007;16:641-51. (Pubitemid 47039530)
35. Petrovic M, van der Cammen T, Onder G. Adverse drug reactions in older people: detection and prevention. Drugs Aging. 2012;29(6):453-62.
36. Somers A, Petrovic M, Robays H, et al. Reporting adverse drug reactions on a geriatric ward: a pilot project. Eur J Clin Pharmacol. 2003;58:707-14. (Pubitemid 36363301)
37. Gillespie U, Alassaad A, Henrohn D, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med. 2009;169:894-900.
38. Onder G, Petrovic M, Tangiisuran B, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med. 2010;170(13):1142-8.
39. World Health Organization. Sweden 1990. Guidelines for ATC Classification. World Health Organization. Collaborating Centre for Drug Statistics Methodology, Norway and Nordic Councils on Medicines.
40. Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc. 1968;16(5):622-6.
41. Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61-5.
42. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-98.
43. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616-31.
44. Rudolph JL, Salow MJ, Angelini MC, et al. The anticholinergic risk scale and anticholinergic adverse effects in older person. Arch Intern Med. 2008;168(5):508-13. (Pubitemid 351547214)
45. Carnahan RM, et al. The anticholinergic drug scale as a measure of drug-related anticholinergic burden: association with serum anticholinergic activity. J Clin Pharmacol. 2006;46:1481-6. (Pubitemid 44704208)
46. Buostani M, et al. Impact of anticholinergics on the aging brain: a review and practical application. Aging Health. 2008;4(3):311-20.
47. Nobili A, Pasina L, Tettamanti M, et al. Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther. 2009;34(4):377-86.
48. Garattini S, Nobili A (2001) Interazioni tra farmaci: una valutazione della loro rilevanza clinica. Selecta Medica Eds, Pavia.
49. Kuperman GJ, Gibson RF. Computer physician order entry: benefits, costs and issues. Arch Intern Med. 2003;139:31-9. (Pubitemid 38124617)
50. Kaushal R, Shojania KG, Bates DW. Benefits of computerized physician order entry and clinical decision support systems on medication safety. Arch Intern Med. 2003;163:1409-16. (Pubitemid 36758913)
51. Mattison ML, Afonso KA, Ngo LH, et al. Preventing potentially inappropriate medication use in hospitalized older patients with a computerized provider order entry warning system. Arch Intern Med. 2010;170(15):1331-6.
52. Tamblyn R, Huang A, Perreault R. The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ. 2003;169:549-56. (Pubitemid 37174595)
53. Laroche ML, Charmes JP, Nouaille Y, et al. Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol. 2007;63(2):177-86. (Pubitemid 46072104)
54. Onder G, Landi F, Cesari M, et al. Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly. Eur J Clin Pharmacol. 2003;59(2):157-62. (Pubitemid 36793729)
55. Corsonello A, Pedone C, Lattanzio F, et al. Potentially inappropriate medications and functional decline in elderly hospitalized patients. J Am Geriatr Soc. 2009;57(6):1007-14.
56. Egger SS, Ratz AE, Bravo AE, et al. Age-related differences in the prevalence of potential drug-drug interactions in ambulatory dyslipidaemic patients treated with statins. Drugs Aging. 2007;24:429-40. (Pubitemid 46795183)
57. Vonbach P, Dubied A, Krahenbuhl S, et al. Prevalence of drug-drug interactions at hospital entry and during hospital stay of patients in internal medicine. Eur J Intern Med. 2008;19:413-20.
58. Egger SS, Drewe J, Schlienger RG. Potential drug-drug interactions in the medication of medical patients at hospital discharge. Eur J Clin Pharmacol. 2003;58(11):773-8. (Pubitemid 36399235)
59. Pasina L, Djade CD, Nobili A. Potentially severe drug-drug interactions in a cohort of hospitalized elderly patients. Pharmacoepidemiol Drug Saf (in press).