Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation

Chinese Journal of Natural Medicines

Volumn 11, Issue 6, 2013, Pages 645-652

  Xie, Yuan ^a   Hao, Hai Ping ^b   Wang, Hong ^b   Wang, Zhao Xian ^a   Wang, Guang Ji ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b China Pharmaceutical University   (China)

Author keywords

CYP3A; Inflammation; Liver injury; PXR; Silybin; Thioacetamide

Indexed keywords

CYTOCHROME P450 3A; MIDAZOLAM; PREGNANE X RECEPTOR; SILIBININ; SMALL INTERFERING RNA; THIOACETAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CELL STRAIN HEPG2; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER; LIVER DYSFUNCTION; LIVER PROTECTION; MALE; NONHUMAN; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THIOACETAMIDE INDUCED HEPATIC CYP3A DYSFUNCTION; WESTERN BLOTTING;

CYP3A; INFLAMMATION; LIVER INJURY; PXR; SILYBIN; THIOACETAMIDE;

ANIMALS; CYTOCHROME P-450 CYP3A; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; LIVER; MALE; MILK THISTLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; SILYMARIN; THIOACETAMIDE;

EID: 84890135437     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(13)60075-8     Document Type: Article

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