Prevention of Epilepsy After Head Trauma: Do We Need New Drugs or a New Approach?

Epilepsia

Volumn 44, Issue SUPPL. 10, 2003, Pages 27-33

  Benardo, Larry S ^a  

^a SUNY Downstate Medical Center   (United States)

Author keywords

GABA; Inhibition; Neocortex; Posttraumatic epilepsy; Valproate

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CARBAMAZEPINE; DANTROLENE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; EXCITOTOXIN; FIBRINOLYTIC AGENT; GABAERGIC RECEPTOR AFFECTING AGENT; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; MAGNESIUM SULFATE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL DAMAGE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; EMERGENCY HEALTH SERVICE; EPILEPTOGENESIS; FEASIBILITY STUDY; HEAD INJURY; HOSPITALIZATION; HUMAN; INCIDENCE; KINDLING; MAJOR CLINICAL STUDY; NEOCORTEX; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PILOT STUDY; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; RISK FACTOR; SEIZURE; TECHNIQUE; TRAUMATIC EPILEPSY; TREATMENT INDICATION; UNITED STATES;

EID: 0142072674     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.44.s10.2.x     Document Type: Review

References (63)

1. Frankowski RF. The demography of head injury in the United States. In: Miner ME, Wagner KA, eds. Neurotrauma: treatment rehabilitation and related issues. Boston: Butterworth, 1986:1-17.
2. Langendorf F, Pedley TA. Post-traumatic seizures. In: Engel J, Pedley TA, eds. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven, 1997:2469-74.
3. Caveness WF. Onset and cessation of fits following craniocerebral trauma. J Neurosurg 1963;20:570-83.
4. Annegers JF, Grabow JD, Groover RV, et al. Seizures after head trauma: a population study. Neurology 1980;30:683-9.
5. Desai BT, Whitman S, Coonley-Hoganson R, et al. Seizures and civilian head injuries. Epilepsia 1983;24:289-96.
6. Jennett WB, Lewin W. Traumatic epilepsy after closed head injuries. J Neurol Neurosurg Psychiatry 1960;23:295-301.
7. Annegers JF, Hauser WA, Coan SP, et al. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998;338:20-4.
8. Hahn YS, Fuchs S, Flannery AM, et al. Factors influencing posttraumatic seizures in children. Neurosurgery 1988;22:864-7.
9. Temkin NR, Dikmen SS, Wilensky AJ, et al. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med 1990;323:497-502.
10. Asikainen I, Kaste M, Sarna S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia 1999;40:584-9.
11. Temkin NR, Haglund MM, Winn HR. Posttraumatic seizures. In: Youmans JR, ed. Neurological surgery. Philadelphia: WB Saunders, 1996:1834-9.
12. Jennett WB. Epilepsy after non-missile head injuries. 2nd ed. London: William Heinemann, 1973:179.
13. Salazar AM, Jabbari B, Vance SC, et al. Epilepsy after penetrating head injury, I: clinical correlates: a report of the Vietnam head injury study. Neurology 1985;35:1406-4.
14. Caveness WF, Walker AE, Ascroft PB. Incidence of post-traumatic epilepsy in Korean veterans as compared with those from World War I and World War II. J Neurosurg 1962;19:122-9.
15. Kilpatrick CJ, Davis SM, Tress BM, et al. Epileptic seizures in acute stroke. Arch Neurol 1990;47:157-60.
16. Popek K. Preventive treatment of post-traumatic epilepsy following severe brain injury. Cesk Neurol 1972;35:35-68.
17. Wohns RNW, Wyler AR. Prophylactic phenytoin in severe head injuries. J Neurosurg 1979;51:507-9.
18. Young B, Rapp RP, Brooks W, et al. Post-traumatic epilepsy prophylaxis. Epilepsia 1979;20:671-81.
19. Rapport RL, Penry JK. A survey of attitudes toward the pharmacologic prophylaxis of posttraumatic epilepsy. J Neurosurg 1973;38:159-66.
20. McQueen JK, Blackwood DHR, Harris P, et al. Low risk of late post-traumatic seizures following severe head injury: implications for clinical trials of prophylaxis. J Neurol Neurosurg Psychiatry 1983;46:899-904.
21. Young B, Rapp RP, Norian JA, et al. Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures. J Neurosurg 1983;58:231-5.
22. Young B, Rapp RP, Norian JA, et al. Failure of prophylactically administered phenytoin to prevent late posttraumatic seizures. J Neurosurg 1983;58:235-41.
23. Manaka S. Cooperative prospective study on posttraumatic epilepsy: risk factors and the effect of prophylactic anticonvulsant. Jpn J Psychiatry Neurol 1992;46:311-5.
24. Penry JK, White BG, Brackett CE. A controlled prospective study of the pharmacologic prophylaxis of posttraumatic epilepsy. Neurology 1979;29:600-1.
25. Glotzner FL, Haubitz I, Miltner F, et al. Anfallsprophylaze mit carbamazepin nach schweren schadelhirnverletzungen. Neurochirurgia 1983;26:66-79.
26. Schierhout G; Roberts I. Prophylactic antiepileptic agents after head injury: a systematic review. J Neurol Neurosurg Psychiatry 1998;64:108-12.
27. Pechadre JC, Lauxerois M, Colnet G, et al. Prevention de l'epelepsie post-traumatique tardive par phenytoine dans les traumatitismes carniens graves: Suivi durant 2 ans. Presse Med 1991;20:841-5.
28. Temkin NR, Dikmen SS, Winn HR. Posttraumatic seizures. North Am Neurosurg Clin 1991;2:425-35.
29. Temkin NR, Dikmen SS, Anderson GD, et al. Valproate therapy for prevention of posttraumatic seizures: a randomized trial. J Neurosurg 1999;91:593-600.
30. Dikmen SS, Temkin NR, Miller B, et al. Neurobehavioral effects of phenytoin prophylaxis of posttraumatic seizures. JAMA 1991;265:1271-7.
31. Schmutz M, Klebs K, Baltzer V. Inhibition or enhancement of kindling evolution by antiepileptics. J Neural Transm 1988;72:245-57.
32. Lockard JS, DuCharme LL, Congdon WC, et al. Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model, II: four-month follow-up period: seizure, EEG, blood, and behavioral data. Epilepsia 1976;17:49-57.
33. Racine RJ, Livingston K, Joaquin A. Effects of procaine hydrochloride, diazepam and diphenylhydantoin on seizure development in cortical and subcortical structures in rat. Electroencephalogr Clin Neurophysiol 1975;8:355-65.
34. Wada JA, Sato M, Wake A. Prophylactic effects of phenytoin, phenobarbital and carbamazepine examined in kindling cat preparations. Arch Neurol 1976;33:426-34.
35. Applegate CD, Samorski GM, Oaduman K. Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. Epilepsia 1997;38:631-6.
36. McNamara JO, Russell RD, Rigsbee L, et al. Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models. Neuropharmacology 1988;27:563-8.
37. Silver JM, Shin C, McNamara JO. Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilepsy. Ann Neurol 1991;29:356-63.
38. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994;330:613-22.
39. Weiss JH, Hartley DM, Koh J, et al. The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science 1990;247:1474-7.
40. ++ influx into striatal neurons by kainic acid. J Pharmacol Exp Ther 1989;249:184-93.
41. 2+ release from intracellular stores in cultured cerebral cortical neurons. J Neurochem 1991;56:1075-8.
42. Chan PH, Fishman RA, Longar S, et al. Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury. Prog Brain Res 1985;63:227-35.
43. Hall ED. Inhibition of lipid peroxidation in CNS trauma. J Neurotrauma 1991;8:S31-4.
44. Siesjo BK, Rehncrona S, Smith D. Neuronal cell damage in the brain: possible involvement of oxidative mechanisms. Acta Physiol Scand Suppl 1980;492:121-8.
45. Kuroda S, Siejo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 1997;4:199-212.
46. Pohlmann-Eden B, Bruckmeir J. Predictors and dynamics of posttraumatic epilepsy. Acta Neurol Scand 1997;95:257-62.
47. Asikainen I, Kaste M, Sarna S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia 1999;40:584-9.
48. Yang L, Benardo LS. Epileptogenesis following neocortical trauma from two sources of disinhibition. J Neurophysiol 1997;78:2804-10.
49. De La Torre JC. Spinal cord injury: review of basic and applied research. Spine 1981;6:315-35.
50. Faden AI. Pharmacotherapy in spinal cord injury: a critical review of recent developments. Clin Neuropharmacol 1987;10:193-204.
51. Graham DI, Adams JH, Gennarelli TA. Pathology of brain damage in head injury. In: Cooper PR, ed. Head injury. Baltimore, MD: Williams & Wilkins, 1987:72-88.
52. Jones EG. GABAergic neurons and their role in cortical plasticity in primates. Cereb Cortex 1993;3:361-72.
53. Peters A, Kara DA. The neuronal composition of area 17 of rat visual cortex, II: the nonpyramidal cells. J Comp Neurol 1985;234:218-41.
54. Akaike N, Harata N, Ueno S, et al. GABAergic synaptic current in dissociated nucleus basalis of Meynert neurons of the rat. Brain Res 1992;570:102-8.
55. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones. J Physiol 1990;320:207-21.
56. Inoue M, Ooumura Y, Yakushui T, et al. Intracellular calcium ions decrease the affinity of the GABA receptor. Nature 1986;324:156-8.
57. A-receptor function in hippocampal cells is maintained by phosphorylation factors. Science 1988;241:339-41.
58. Llano I, Leresche N, Marty A. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 1991;6:565-74.
59. A receptor by intracellular ATP in dissociated nucleus tractus solitarii neurones of rat. J Physiol 1992;449:551-72.
60. Yang L, Benardo LS. Valproate prevents posttraumatic seizure activity in an in vitro model in neocortical slices. Epilepsia 2000;41:1507-13.
61. Ko GYL, Brown-Croyts LM, Teyler TJ. The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus. Brain Res Bull 1997;42:297-302.
62. Preisendorfer U, Zeise ML, Klee MR. Valproate enhances inhibitory postsynaptic potentials in hippocampal neurons in vitro. Brain Res 1987;435:213-9.
63. Sokolova S, Schmitz D, Zhang CL, et al. Comparison of effects of valproate and trans-2-en-valproate on different forms of epileptiform activity in rat hippocampal and temporal cortex slices. Epilepsia 1998;39:251-8.