Resistin derived from diabetic perivascular adipose tissue up-regulates vascular expression of osteopontin via the AP-1 signalling pathway

Journal of Pathology

Volumn 232, Issue 1, 2014, Pages 87-97

  Park, So Youn ^b   Kim, Kyu Hee ^c   Seo, Kyo Won ^b   Bae, Jin Ung ^b   Kim, Yun Hak ^b   Lee, Seung Jin ^b   Lee, Won Suk ^a   Kim, Chi Dae ^a,b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Korea National Institute of Health   (South Korea)

Author keywords

macrophage; obesity; OPN; PVAT; resistin

Indexed keywords

ADIPOCYTOKINE; MESSENGER RNA; NEUTRALIZING ANTIBODY; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OSTEOPONTIN; RESISTIN; TRANSCRIPTION FACTOR AP 1;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DIABETIC PERIVASCULAR ADIPOSE TISSUE; GENE; GENETIC TRANSCRIPTION; IN VITRO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; OPN GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

MACROPHAGE; OBESITY; OPN; PVAT; RESISTIN;

ADIPOSE TISSUE; ANIMALS; AORTA; BASE SEQUENCE; BODY WEIGHT; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OBESITY; OSTEOPONTIN; RATS; RESISTIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 84890099184     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4286     Document Type: Article

References (46)

1. Rajsheker S, Manka D, Blomkalns AL, et al., Crosstalk between perivascular adipose tissue and blood vessels. Curr Opin Pharmacol 2010; 10: 191-196.
2. Tilg H, Moschen AR,. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-783.
3. Skilton MR, Sérusclat A, Sethu AH, et al., Noninvasive measurement of carotid extra-media thickness: associations with cardiovascular risk factors and intima-media thickness. JACC Cardiovasc Imaging 2009; 2: 176-182.
4. Gao YJ, Lu C, Su LY, et al., Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 2007; 151: 323-331.
5. Gao YJ, Holloway AC, Su LY, et al., Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life. Eur J Pharmacol 2008; 590: 264-268.
6. Lu C, Su LY, Lee RM, et al., Alterations in perivascular adipose tissue structure and function in hypertension. Eur J Pharmacol 2011; 656: 68-73.
7. Greif M, Becker A, von Ziegler F, et al., Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol 2009; 29: 781-786.
8. Payne GA, Borbouse L, Kumar S, et al., Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-β pathway. Arterioscler Thromb Vasc Biol 2010; 30: 1711-1717.
9. Takemoto M, Yokote K, Nishimura M, et al., Enhanced expression of osteopontin in human diabetic artery and analysis of its functional role in accelerated atherogenesis. Arterioscler Thromb Vasc Biol 2000; 20: 624-628.
10. Panda D, Kundu GC, Lee BI, et al., Potential roles of osteopontin and αVβ3 integrin in the development of coronary artery restenosis after angioplasty. Proc Natl Acad Sci USA 1997; 94: 9308-9313.
11. Li JJ, Zhu CG, Yu B, et al., The role of inflammation in coronary artery calcification. Ageing Res Rev 2007; 6: 263-270.
12. Shimizu H, Takahashi M, Takeda S, et al., Mycophenolate mofetil prevents transplant arteriosclerosis by direct inhibition of vascular smooth muscle cell proliferation. Transplantation 2004; 77: 1661-1667.
13. Li G, Oparil S, Kelpke SS, et al., Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro. Circulation 2002; 106: 854-859.
14. Yin BL, Hao H, Wang YY, et al., Down-regulating osteopontin reduces angiotensin II-induced inflammatory activation in vascular smooth muscle cells. Inflamm Res 2009; 58: 67-73.
15. Scatena M, Liaw L, Giachelli CM,. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007; 27: 2302-2309.
16. Henrichot E, Juge-Aubry CE, Pernin A, et al., Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol 2005; 25: 2594-2599.
17. Greenstein AS, Khavandi K, Withers SB, et al., Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009; 119: 1661-1670.
18. Bruemmer D, Collins AR, Noh G, et al., Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 2003; 112: 1318-1331.
19. Langheim S, Dreas L, Veschini L, et al., Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome. Am J Physiol Heart Circ Physiol 2010; 298: 746-753.
20. Chatterjee TK, Stoll LL, Denning GM, et al., Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding. Circ Res 2009; 104: 541-549.
21. Takaoka M, Suzuki H, Shioda S, et al., Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler Thromb Vasc Biol 2010; 30: 1576-1582.
22. Stofkova A., Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul 2010; 44: 25-36.
23. Bokarewa M, Nagaev I, Dahlberg L, et al., Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005; 174: 5789-5795.
24. Shalev A, Patterson NB, Hirshberg B, et al., Resistin serum levels in type 1 diabetes pre- and post-islet transplantation. Metabolism 2004; 53: 403-404.
25. Giachelli CM, Bae N, Almeida M, et al., Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 1993; 92: 1686-1696.
26. Isoda K, Nishikawa K, Kamezawa Y, et al., Osteopontin plays an important role in the development of medial thickening and neointimal formation. Circ Res 2002; 91: 77-82.
27. Isoda K, Kamezawa Y, Ayaori M, et al., Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions. Circulation 2003; 107: 679-681.
28. Bruemmer D, Collins AR, Noh G, et al., Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 2003; 112: 1318-1331.
29. Matsui Y, Rittling SR, Okamoto H, et al., Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2003; 23: 1029-1034.
30. Scatena M, Liaw L, Giachelli CM,. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007; 27: 2302-2309.
31. Nomiyama T, Perez-Tilve D, Ogawa D, et al., Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 2007; 117: 2877-2828.
32. Police SB, Thatcher SE, Charnigo R, et al., Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 2009; 29: 1458-1464.
33. Takaoka M, Suzuki H, Shioda S, et al., Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler Thromb Vasc Biol 2010; 30: 1576-1582.
34. Miao CY, Li ZY,. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol 2012; 165: 643-658.
35. Stofkova A., Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul 2010; 44: 25-36.
36. Calabro P, Samudio I, Willerson JT, et al., Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation 2004; 110: 3335-3340.
37. Steppan CM, Lazar MA,. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2002; 13: 18-23.
38. Rea R, Donnelly R,. Resistin: an adipocyte-derived hormone. Has it a role in diabetes and obesity? Diabetes Obes Metab 2004; 6: 163-170.
39. Patel L., Objective assessment of pancreatic function in all patients with cystic fibrosis. J Pediatr 2005; 147: 127-128.
40. Shyu KG, Lien LM, Wang BW, et al., Resistin contributes to neointimal formation via oxidative stress after vascular injury. Clin Sci (Lond) 2011; 120: 121-129.
41. Shin HJ, Park S, Yoon SJ, et al., Association between serum resistin and carotid intima media thickness in hypertension patients. Int J Cardiol 2008; 125: 79-84.
42. Miao CY, Li ZY,. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol 2012; 165: 643-658.
43. Nilsson-Berglund LM, Zetterqvist AV, Nilsson-Ohman J, et al., Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia. Arterioscler Thromb Vasc Biol 2010; 30: 218-224.
44. Sun J, Xu Y, Dai Z, et al., Intermittent high glucose enhances proliferation of vascular smooth muscle cells by upregulating osteopontin. Mol Cell Endocrinol 2009; 313: 64-69.
45. Gan AM, Butoi ED, Manea A, et al., Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1, expression by TLR4 and Gi-protein pathways. Cell Tissue Res 2013; 351: 161-174.
46. Verma S, Li SH, Wang CH, et al., Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 2003; 108: 736-740.