Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro

Circulation

Volumn 106, Issue 7, 2002, Pages 854-859

  Li, Guohong ^a,b   Oparil, Suzanne ^a   Kelpke, Stacey S ^a   Chen, Yiu Fai ^a   Thompson, John A ^a  

^a University of Alabama at Birmingham   (United States)

^b 1024 Zeigler Research Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 DIMETHYLAMINO 1 PHENYL 6 PYRIDAZONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOHEXIMIDE; DACTINOMYCIN; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OSTEOPONTIN; PD 166866; PROTEIN SYNTHESIS INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RNA POLYMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; FIBROBLAST; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FIBROBLAST GROWTH FACTOR 1; FIBROBLASTS; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; NUCLEIC ACID SYNTHESIS INHIBITORS; OSTEOPONTIN; PRECIPITIN TESTS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION;

EID: 0037072456     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000024113.26985.CC     Document Type: Article

References (25)

1. Giachelli CM, Bae N, Almeida M, et al. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest. 1993;92:1686-1696.
2. 5, and osteopontin are coordinately upregulated at early time points in a rabbit model of neointima formation. J Cell Biol. 1999;75:492-504.
3. O'Brien ER, Garvin MR, Stewart DK, et al. Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaque. Arterioscler Thromb Vasc Biol. 1994;14:1648-1656.
4. Takemoto M, Yokote K, Nishimura M, et al. Enhanced expression of osteopontin in human diabetic artery and analysis of its functional role in accelerated atherogenesis. Arterioscler Thromb Vasc Biol. 2000;20:624-628.
5. Liaw L, Lombardi DM. Almeida MM, et al. Neutralizing antibodies directed against osteopontin inhibit rat carotid neointima thickening after endothelial denudation. Arterioscler Thromb Vasc Biol. 1997;17:188-193.
6. 3 and osteopontin expression during neointima formation. Cardiovasc Res. 1997;36:408-428.
7. 3-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation. 2001;103:1906-1911.
8. 3-dependent adventitial fibroblast migration after inhibition of osteopontin production in vascular smooth muscle cells. Circulation. 2000;101:2949-2955.
9. Brogi E, Winkless JA, Underwood R, et al. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries: association of acidic FGF with plaque microvessels and macrophages. J Clin Invest. 1993;92:2408-2418.
10. Hughes SE, Crossman D, Hall PA. Expression of basic and acidic fibroblast growth factors and their receptor in normal and atherosclerotic human arteries. Cardiovasc Res, 1993;27:1214-1219.
11. Zhao XM, Frist WH, Yeoh TK, et al. Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. J Clin Invest. 1994;94:992-1003.
12. Farb A, Lee SJ, Min DH, et al. Vascular smooth muscle cell cytotoxicity and sustained inhibition of neointima formation by fibroblast growth factor 2-saporin fusion protein. Cir Res. 1997;80:542-550.
13. Daley SJ, Gotlieb AI. Fibroblast growth factor receptor-1 expression is associated with neointima formation in vitro. Am J Pathol. 1996;148:1193-1202.
14. Nabel EG, Yang ZY, Plautz G, et al. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo. Nature. 1993;362:844-846.
15. Ross R. Growth of smooth muscle cell in culture and formation of elastic fibers. J Cell Biol. 1971;50:172-186.
16. Wang XK, Louden C, Ohlstein EH, et al. Osieopontin expression in platelet-derived growth factor-stimulated vascular smooth muscle cells and carotid artery after balloon angioplasty. Arterioscler Thromb Vasc Biol. 1996;16:1365-1372,
17. Casscells W, Lappi DA, Olwin BB, et al. Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors. Proc Natl Acad Sci U S A. 1992;89:7159-7163.
18. Klint P, Claesson-Welsh L. Signal transduction by fibroblast growth factor receptors. Frontiers Biosci, 1999;4:D165-D177.
19. Burgess WH, Dionne CA, Kaplow J, et al. Characterization and cDNA cloning of phospholipase C-γ, a major substrate for heparin-binding growth factor-1 (acidic fibroblast growth factor) activated tyrosine kinase. Mol Cell Biol. 1990;10:4770-4777.
20. LaVallee TM, Prudovsky IA, McMahon GA, et al. Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration. J Cell Biol. 1998;141:1647-1658.
21. Panek RL, Lu GH, Dahring TK, et al. In vitro biological characterization and antiangiogenic effects of PD166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998;286: 569-577.
22. Lindner V, Reidy MA. Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries: an en face study. Circ Res. 1993;73:589-595.
23. Xin X, Johnson AD, Scott-Burden T, et al. The predominant form of fibroblast growth factor receptor expressed by proliferating human arterial smooth muscle cells in culture is type I. Biochem Biophys Res Commun. 1994;204:557-564.
24. Sartore S, Chiavegato A, Faggin E, et al. Contribution of adventitial fibroblast to neointima formation and vascular remodeling: from innocent bystander to active participant. Circ Res. 2001;89:1111-1121.
25. Li GH, SJ Chen, Oparil S, et al. Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts following balloon injury of rat carotid arteries. Circulation. 2000;101:1362-1365.