Autocrine VEGF signaling promotes proliferation of neoplastic barrett's epithelial cells through a PLC-dependent pathway

Gastroenterology

Volumn 146, Issue 2, 2014, Pages

  Zhang, Qiuyang ^a   Yu, Chunhua ^a   Peng, Sui ^a,b   Xu, Hao ^a   Wright, Ellen ^c   Zhang, Xi ^a   Huo, Xiaofang ^a   Cheng, Edaire ^a,d   Pham, Thai H ^a   Asanuma, Kiyotaka ^a   Hatanpaa, Kimmo J ^a   Rezai, Davood ^a,c   Wang, David H ^a,e   Sarode, Venetia ^a   Melton, Shelby ^a   Genta, Robert M ^a,f   Spechler, Stuart J ^a,e   Souza, Rhonda F ^a,e  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^d CHILDREN S MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f MIRACA LIFE SCIENCES   (United States)

Author keywords

Apoptosis; Esophageal Cancer; Mouse Model; Vascular Endothelial Growth Factor Receptor 2

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE C; SUNITINIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; BARRETT ESOPHAGUS; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; EPITHELIUM CELL; ESOPHAGEAL ADENOCARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; TUMOR XENOGRAFT;

APOPTOSIS; BAR-T; BRDU; BROMODEOXYURIDINE; ERK; ESOPHAGEAL CANCER; EXTRACELLULAR SIGNAL-REGULATED KINASE; MESSENGER RNA; MOUSE MODEL; MRNA; NON-NEOPLASTIC, TELOMERASE-IMMORTALIZED BARRETT'S EPITHELIAL CELL; PHOSPHOLIPASE C; PHOSPHOLIPASE CΓ1; PKC; PLC; PLCG1; PROTEIN KINASE C; RECOMBINANT HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR; RHVEGF; SHORT-HAIRPIN RNA; SHRNA; SIRNA; SMALL INTERFERING RNA; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR NEUTRALIZATION ANTIBODY; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2; VEGF; VEGF-NA; VEGFR;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOCRINE COMMUNICATION; BARRETT ESOPHAGUS; BIOLOGICAL MARKERS; CELL LINE; CELL PROLIFERATION; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; MAP KINASE SIGNALING SYSTEM; MICE; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PRECANCEROUS CONDITIONS; PROTEIN KINASE C; PYRROLES; REAL-TIME POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84890090885     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.011     Document Type: Article

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