Microcystins and two new micropeptin cyanopeptides produced by unprecedented Microcystis aeruginosa blooms in North Carolina's Cape Fear River

Harmful Algae

Volumn 31, Issue , 2014, Pages 82-86

  Isaacs, Justin D ^a   Strangman, Wendy K ^a   Barbera, Amy E ^a   Mallin, Michael A ^a   McIver, Matthew R ^a   Wright, Jeffrey L C ^a  

^a UNIVERSITY OF NORTH CAROLINA WILMINGTON   (United States)

Author keywords

Cape Fear River; Cyanopeptide; Harmful algal bloom; Microcystin; Microcystis aeruginosa; Micropeptin; North Carolina

Indexed keywords

EID: 84890053741     PISSN: 15689883     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hal.2013.09.010     Document Type: Article

References (27)

1. Burkholder J.M. Cyanobacteria. Encyclopedia of Environmental Microbiology 2002, 952-982. Wiley Publishers, New York. G. Bitton (Ed.).
2. Carmichael W.W., Azevedo S.M., An J.S., Molica R.J., Jochimsen E.M., Lau S., Rinehart K.L., Shaw G.R., Eaglesham G.K. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environmental Health Perspectives 2001, 109:663-668.
3. Codd G.A., Morrison L.F., Metcalf J.S. Cyanobacterial toxins: risk management for health protection. Toxicology and Applied Pharmacology 2005, 203:264-272.
4. Demott W.R., Moxter F. Foraging on cyanobacteria by copepods: responses to chemical defenses and resource abundance. Ecology 1991, 72:1820-1834.
5. Dubbs L.L., Whalen S.C. Light-nutrient influences on biomass, photosynthetic potential and composition of suspended algal assemblages in the middle Cape Fear River, USA. International Review of Hydrobiology 2008, 93:711-730.
6. Falconer I.R. Effects on human health of some toxic cyanobacteria (blue-green algae) in reservoirs, lakes and rivers. Toxicity Assessment: An International Journal 1989, 4:175-184.
7. de Figueiredo D.R., Azeiteiro U.M., Esteves S.M., Gonçalves F.J.M., Pereira M.J. Microcystin-producing blooms - a serious global public health issue. Ecotoxicology and Environmental Safety 2004, 59:151-163.
8. Fujii K., Ikai Y., Oka H., Suzuki M., Harada K. A nonempirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: combination of Marfey's method with mass spectrometry and its practical application. Analytical Chemistry 1997, 69:5146-5151.
9. Gademann K., Portmann C. Secondary metabolites from cyanobacteria: complex structures and powerful bioactivities. Current Organic Chemistry 2008, 12:326-341.
10. Garcia C.Z., Martinez C. Biochemical and genetic alterations in the freshwater neotropical fish Prochilodus lineatus after acute exposure to Microcystis aeruginosa. Neotropical Ichthyology 2012, 10:613-622.
11. Gupta S.C.N., Vijayaraghavan P.R., Lakshmana Rao P.V. Comparative toxicology evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 2003, 188:285-296.
12. Hereman T.C., Bittencourt-Oliveira M., Do C. Bioaccumulation of microcystins in lettuce. Journal of Phycology 2012, 48:1535-1537.
13. Ikehara T., Imamura S., Sano T., Nakashima J., Kuniyoshi K., Oshiro N., Yoshimoto M., Yasumoto T. The effect of structural variation in 21 microcystins on their inhibition of PP2A and the effect of replacing cys269 with glycine. Toxicon 2009, 54:539-544.
14. Ishida K., Matsuda H., Murakami M. Micropeptins 88A to 88F, chymotrypsin inhibitors from the cyanobacterium Microcystis aeruginosa (NIES-88). Tetrahedron 1998, 54:5545-5556.
15. Kozlowsky-Suzuki B., Wilson A., Ferrão-Filho A. Biomagnification or biodilution of microcystins in aquatic foodwebs? Meta-analyses of laboratory and field studies. Harmful Algae 2012, 18:47-55.
16. Lifshits M., Carmeli S. Metabolites of Microcystis aeruginosa bloom material from Lake Kinnereto, Israel. Journal of Natural Products 2012, 75:209-219.
17. Mallin M.A., Cahoon L.B., McIver M.R., Parsons D.C., Shank G.C. Alternation of factors limiting phytoplankton production in the Cape Fear Estuary. Estuaries 1999, 22:985-996.
18. Michalak A.M., Anderson E.J., Beletsky D., Boland S., Bosch N.S., Bridgeman T.B., Chaffin J.D., Cho K., Confesor R., Daloglu I., Depinto J.V., Evans M.A., Fahnenstiel G.L., He L., Ho J.C., Jenkins L., Johengen T.H., Kuo K.C., Laporte E., Liu X., McWilliams M.R., Moore M.R., Posselt D.J., Richards R.P., Scavia D., Steiner A.L., Verhamme E., Wright D.M., Zagorsk M.A. Record-setting algal bloom in Lake Erie caused by agricultural and meteorological trends consistent with expected future conditions. Proceedings of the National Academy of Sciences 2013, (Online Early Addition).
19. NCDENR Cape Fear River Basinwide Water Quality Plan 2005, North Carolina Department of Environment and Natural Resources, Division of Water Quality/Planning, Raleigh, NC.
20. Nishizawa T., Ueda A., Nakano T., Nishizawa A., Miura T., Asayama M., Fujii K., Harada K., Shirai M. Characterization of the locus of genes encoding enzymes producing heptadepsipeptide Micropeptin in the unicellular cyanobacterium Microcystis. Journal of Biochemistry 2011, 149:475-485.
21. Rogers E., Henry T., Twiner M., Gouffon J., McPherson J., Boyer G., Sayler G., Wilhelm S. Global gene expression profiling in larval zebrafish exposed to microcystin-LR and Microcystis reveals endocrine disrupting effects of cyanobacteria. Environmental Science and Technology 2011, 45:1962-1969.
22. Smith V.H. Eutrophication of freshwater and coastal marine ecosystems: a global problem. Environmental Science Pollution Research International 2003, 10:126-139.
23. Vasconcelos V.M. Preliminary results of a study on the impact of toxic and nontoxic cyanobacteria on some freshwater microcrustacean species. Crustaceana 1990, 59:316-318.
24. Welker M., Von Döhren H. Cyanobacterial peptides - nature's own combinatorial biosynthesis. FEMS Microbiology Reviews 2006, 30:530-563.
25. Welschmeyer N.A. Fluorometric analysis of chlorophyll a in the presence of chlorophyll b and phaeopigments. Limnology and Oceanography 1994, 39:1985-1993.
26. Wiegand C., Pflugmacher S. Ecotoxicological affects of selected cyanobacterial secondary metabolites: a short review. Toxicology and Applied Pharmacology 2005, 203:201-218.
27. World Health Organization (WHO) Toxic Cyanobacteria in Water: A Guide to their Public Health Consequences, Monitoring and Management 1999, Routledge, London/New York.