The effect of structural variation in 21 microcystins on their inhibition of PP2A and the effect of replacing cys269 with glycine

Toxicon

Volumn 54, Issue 4, 2009, Pages 539-544

  Ikehara, Tsuyoshi ^a   Imamura, Shihoko ^a   Sano, Tomoharu ^b   Nakashima, Junichi ^a   Kuniyoshi, Kyoko ^a   Oshiro, Naomasa ^c   Yoshimoto, Masahiro ^d   Yasumoto, Takeshi ^e  

^a Tropical Technology Center Ltd   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c OKINAWA PREFECTURAL INSTITUTE OF HEALTH AND ENVIRONMENT   (Japan)

^d Okinawa Institute for the Conservation   (Japan)

^e Okinawa Institute of Science and Technology   (Japan)

Author keywords

Conversion factors; Cytotoxicity assay; Microcystins (MCs); PP2A assay; Protein phosphatase 2A (PP2A)

Indexed keywords

BACTERIAL TOXIN; CYANOGINOSIN YR; CYSTEINE; GLYCINE; MICROCYSTIN; MICROCYSTIN FR; MICROCYSTIN LA; MICROCYSTIN LF; MICROCYSTIN LR; MICROCYSTIN LW; MICROCYSTIN RR; MICROCYSTIN WR; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEMETHYLATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; MUTANT; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TOXIN STRUCTURE; WILD TYPE;

AMINO ACID SEQUENCE; CELLS, CULTURED; CYSTEINE; GLYCINE; HUMANS; MICROCYSTINS; MOLECULAR SEQUENCE DATA; PROTEIN PHOSPHATASE 2; TOXICITY TESTS;

CYANOBACTERIA; MICROCYSTIS;

EID: 67650253808     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.05.028     Document Type: Article

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