DMSO-enhanced MALDI MS imaging with normalization against a deuterated standard for relative quantification of dasatinib in serial mouse pharmacology studies

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 29, 2013, Pages 9467-9476

  Schulz, Sandra ^a   Gerhardt, Dimitri ^a,c   Meyer, Björn ^a,b   Seegel, Maic ^c   Schubach, Bernhard ^c   Hopf, Carsten ^a,b   Matheis, Katerina ^c  

^a MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MERCK KGAA   (Germany)

Author keywords

Dasatinib; Internal standard; Matrix assisted laser desorption ionization mass spectrometry imaging; Quantification

Indexed keywords

DASATINIB; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MASS-SPECTROMETRY IMAGING; MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY; QUANTIFICATION; RELATIVE QUANTIFICATION; TYROSINE KINASE INHIBITOR;

AMINO ACIDS; DEUTERIUM; DIMETHYL SULFOXIDE; LIQUID CHROMATOGRAPHY; MAMMALS; ORGANIC SOLVENTS;

MASS SPECTROMETRY;

DASATINIB; DEUTERIUM; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CHEMISTRY; EQUIPMENT; EVALUATION STUDY; FEMALE; ISOTOPE LABELING; KIDNEY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; STANDARD;

ANIMALS; DEUTERIUM; FEMALE; ISOTOPE LABELING; KIDNEY; MICE; MICE, INBRED C57BL; PYRIMIDINES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIAZOLES;

EID: 84890036974     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7393-0     Document Type: Article

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