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Volumn 13, Issue 12 SUPPL., 2013, Pages 11-19

Decoding multiple sclerosis: An update on genomics and future directions

Author keywords

allelic variation; genetics; genomics; human genome; multiple sclerosis; susceptibility

Indexed keywords

CD40 ANTIGEN; CD6 ANTIGEN; CD86 ANTIGEN; FOCAL ADHESION KINASE 1; HLA DRB1 ANTIGEN; HLA DRB5 ANTIGEN; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ANTIBODY; INTERLEUKIN 22; INTERLEUKIN 7; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE TYK2; STAT3 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3;

EID: 84890036481     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2013.865867     Document Type: Conference Paper
Times cited : (56)

References (23)
  • 1
    • 84926996526 scopus 로고    scopus 로고
    • Chapter 235 2 The role of genetics in multiple sclerosis
    • OMMBID). Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A (Eds). McGraw-Hill, NY, USA
    • Johnson BA, Oksenberg Jr. Chapter 235. 2. The role of genetics in multiple sclerosis. In: Scriver's Online Metabolic and Molecular Bases of Inherited Disease (OMMBID). Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A (Eds). McGraw-Hill, NY, USA (2012
    • (2012) Scriver's Online Metabolic and Molecular Bases of Inherited Disease
    • Johnson, B.A.1    Oksenberg, J.R.2
  • 2
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • International Multiple Sclerosis Genetics Consortium
    • International Multiple Sclerosis Genetics Consortium. Risk alleles for multiple sclerosis identified by a genomewide study. N. Engl. J. Med. 357(9), 851-862 (2007
    • (2007) N. Engl. J. Med , vol.357 , Issue.9 , pp. 851-862
  • 3
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), 661-678 (2007
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 4
    • 55849139823 scopus 로고    scopus 로고
    • Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms
    • Comabella M, Craig DW, Camiña-Tato M et al. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS ONE 3(10), e3490 (2008
    • (2008) PLoS ONE , vol.3 , Issue.10
    • Comabella, M.1    Craig, D.W.2    Camiña-Tato, M.3
  • 5
    • 58949099391 scopus 로고    scopus 로고
    • Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    • Baranzini SE, Wang J, Gibson N et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum. Mol. Genet. 15: 767-778 (2009
    • (2009) Hum. Mol. Genet , vol.15 , pp. 767-778
    • Baranzini, S.E.1    Wang, J.2    Gibson, N.3
  • 6
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene
    • Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat. Genet. 41(7), 824-828 (2009
    • (2009) Nat. Genet , vol.41 , Issue.7 , pp. 824-828
  • 7
    • 76049083598 scopus 로고    scopus 로고
    • Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
    • Jakkula E, Leppä V, Sulonen AM et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am. J. Hum. Genet. 86(2), 285-291 (2010
    • (2010) Am. J. Hum. Genet , vol.86 , Issue.2 , pp. 285-291
    • Jakkula, E.1    Leppä, V.2    Sulonen, A.M.3
  • 8
    • 77952884985 scopus 로고    scopus 로고
    • Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
    • Sanna S, Pitzalis M, Zoledziewska M et al. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat. Genet. 42(6), 495-497 (2010
    • (2010) Nat. Genet , vol.42 , Issue.6 , pp. 495-497
    • Sanna, S.1    Pitzalis, M.2    Zoledziewska, M.3
  • 9
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2
    • International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476(7359), 214-219 (2011
    • (2011) Nature , vol.476 , Issue.7359 , pp. 214-219
  • 10
    • 84860524935 scopus 로고    scopus 로고
    • Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1
    • Matesanz F, González-Pérez A, Lucas M et al. Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. PLoS ONE 7(5), e36140 (2012
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Matesanz, F.1    González-Pérez, A.2    Lucas, M.3
  • 11
    • 45549092100 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    • Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9(7), 516-526 (2008
    • (2008) Nat. Rev. Genet , vol.9 , Issue.7 , pp. 516-526
    • Oksenberg, J.R.1    Baranzini, S.E.2    Sawcer, S.3    Hauser, S.L.4
  • 12
    • 79960279940 scopus 로고    scopus 로고
    • Promise and pitfalls of the Immunochip
    • Cortes A, Brown MA. Promise and pitfalls of the Immunochip. Arthritis Res. Ther. 13(1), 101 (2011
    • (2011) Arthritis Res. Ther , vol.13 , Issue.1 , pp. 101
    • Cortes, A.1    Brown, M.A.2
  • 13
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium
    • International Multiple Sclerosis Genetics Consortium. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45, 1353-1360 (2013
    • (2013) Nat. Genet , vol.45 , pp. 1353-1360
  • 14
    • 79551484517 scopus 로고    scopus 로고
    • Aggregation of multiple sclerosis genetic risk variants in multiple and single case families
    • Gourraud PA, McElroy JP, Caillier SJ et al. Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann. Neurol. 69(1), 65-74 (2011
    • (2011) Ann. Neurol , vol.69 , Issue.1 , pp. 65-74
    • Gourraud, P.A.1    McElroy, J.P.2    Caillier, S.J.3
  • 15
    • 84881307811 scopus 로고    scopus 로고
    • Genetic risk variants in African Americans with multiple sclerosis
    • Isobe N, Gourraud PA, Harbo HF et al. Genetic risk variants in African Americans with multiple sclerosis. Neurology 81(3), 219-227 (2013
    • (2013) Neurology , vol.81 , Issue.3 , pp. 219-227
    • Isobe, N.1    Gourraud, P.A.2    Harbo, H.F.3
  • 16
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory SG, Schmidt S, Seth P et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat. Genet. 39(9), 1083-1091 (2007
    • (2007) Nat. Genet , vol.39 , Issue.9 , pp. 1083-1091
    • Gregory, S.G.1    Schmidt, S.2    Seth, P.3
  • 17
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • Maier LM, Lowe CE, Cooper J et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 5(1), e1000322 (2009
    • (2009) PLoS Genet , vol.5 , Issue.1
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3
  • 18
    • 84865261493 scopus 로고    scopus 로고
    • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    • Gregory AP, Dendrou CA, Attfield KE et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488(7412), 508-511 (2012
    • (2012) Nature , vol.488 , Issue.7412 , pp. 508-511
    • Gregory, A.P.1    Dendrou, C.A.2    Attfield, K.E.3
  • 20
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6 IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, Jia X, Wang J et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 41(7), 776-782 (2009
    • (2009) Nat. Genet , vol.41 , Issue.7 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3
  • 21
    • 79952158486 scopus 로고    scopus 로고
    • Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility
    • Couturier N, Bucciarelli F, Nurtdinov RN et al. Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility. Brain 134(Pt 3), 693-703 (2011
    • (2011) Brain , vol.134 , Issue.PART 3 , pp. 693-703
    • Couturier, N.1    Bucciarelli, F.2    Nurtdinov, R.N.3
  • 22
    • 80053067705 scopus 로고    scopus 로고
    • The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation
    • Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation. J. Immunol. 187(6), 3286-3291 (2011
    • (2011) J. Immunol , vol.187 , Issue.6 , pp. 3286-3291
    • Kofler, D.M.1    Severson, C.A.2    Mousissian, N.3    De Jager, P.L.4    Hafler, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.