One-pot synthesis of 3-methylflavones and their transformation into (E)-3-styrylflavones via Wittig reactions

Synlett

Volumn 24, Issue 20, 2013, Pages 2683-2686

  Rocha, Djenisa H A ^a   Pinto, Diana C G A ^a   Silva, Artur M S ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

3 methylflavones; 3 styrylflavones; lithium bis(trimethylsilyl)amide; phosphonium salts; Wittig reaction

Indexed keywords

1 (2 HYDROXYPHENYL) 3 (4 METHOXYPHENYL) 2 METHYLPROPANE 1,3 DIONE; 2 [3 (4 METHOXYPHENYL) 2 METHYL 3 OXO PROPANOYL] PHENYL 4 METHOXYBENZOATE; 2 PROPIONYLPHENYL 4 METHOXYBENZOATE; 3 (4 NITROSTYRYL)FLAVONE; 3 (BROMOTRIPHENYLPHOSPHORANYL)METHYL 4' CHLOROFLAVONE; 3 (BROMOTRIPHENYLPHOSPHORANYL)METHYLFLAVONE DERIVATIVE; 3 BROMOMETHYLFLAVONE DERIVATIVE; 3 METHYL 5,7,4' TRIMETHOXYFLAVONE; 3 METHYLFLAVONE DERIVATIVE; 3 STYRYLFLAVONE DERIVATIVE; FLAVONE DERIVATIVE; PHOSPHORUS DERIVATIVE; STYRYLFLAVONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; ONE POT SYNTHESIS; REACTION OPTIMIZATION; STEREOCHEMISTRY; WITTIG REACTION;

EID: 84889888743     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0033-1340013     Document Type: Article

References (12)

1. Andersen O M., Markham K. R. Flavonoids: Chemistry, Biochemistry and Applications. Taylor & Francis Boca Raton: 2006
2. Birt D. F., Hendrich S., Wang W. Pharmacol. Ther.: 2001; 90 157
3. Verma A. K., Pratap R. Nat. Prod. Rep.: 2010; 27 1571
4. Cummings J., Double J. A., Bibby M. C., Farmer P., Evans S., Kerr D. J., Kaye S. B., Smyth J. F. Cancer Res.: 1989; 49 3587
5. Cárdenas M., Marder M., Blank V. C., Roguin L. P. Bioorg. Med. Chem.: 2006; 14 2966
6. Lin Y.-P, Hsu F.-L, Chen C.-S, Chern J.-W, Lee M.-H. Phytochemistry: 2007; 68 1189
7. Zhu J. T. T, Choi R. C. Y, Chu G. K. Y, Cheung A. W. H, Gao Q. T., Li J., Jiang Z. Y., Dong T. T. X, Tsim K. W. K. J. Agric. Food Chem.: 2007; 55 2438
8. Park K. Y., Lee S.-H, Min B.-K, Lee K.-S, Choi J.-S, Chung S. R., Min K. R., Kim Y. Planta Med.: 1999; 65 457
9. Nagaoka T., Banskota A. H., Tezuka Y., Midorikawa K., Matsushige K., Kadota S. Biol. Pharm. Bull.: 2003; 26 487
10. Moscatelli V., Hnatyszyn O., Acevedo C., Megias J., Alcaraz M. J., Ferrana G. Planta Med.: 2006; 72 72
11. Beyer G., Melzig M. F. Planta Med.: 2003; 69 1125
12. Vaya J., Mahmood S., Goldblum A., Aviram M., Volkova N., Shaalan A., Musa R., Tamir S. Phytochemistry: 2003; 62 89