Mindfulness based intervention in Parkinson's disease leads to structural brain changes on MRI: A randomized controlled longitudinal trial

Clinical Neurology and Neurosurgery

Volumn 115, Issue 12, 2013, Pages 2419-2425

  Pickut, Barbara A ^a,d,e   Van Hecke, Wim ^a,b   Kerckhofs, Eric ^c   Mariën, Peter ^c,d   Vanneste, Sven ^a   Cras, Patrick ^a,e   Parizel, Paul M ^a  

^a ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^b Icometrix   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d Department of Orthopaedic Surgery   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Gray matter density; Magnetic resonance imaging; Mindfulness based intervention; Mindfulness based stress reduction; Parkinson's disease

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CUNEUS; DENTATE NUCLEUS; FEMALE; FOLLOW UP; GRAY MATTER; HIPPOCAMPUS; HUMAN; LINGUAL GYRUS; LONGITUDINAL STUDY; MALE; MEDITATION; MINDFULNESS BASED INTERVENTION; MINDFULNESS BASED STRESS REDUCTION; NEUROIMAGING; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OCCIPITAL LOBE; PARIETAL LOBE; PARKINSON DISEASE; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; REVIEW; TEMPORAL LOBE; THALAMUS; TREATMENT OUTCOME; VOXEL BASED MORPHOMETRY;

GRAY MATTER DENSITY; MAGNETIC RESONANCE IMAGING; MINDFULNESS BASED INTERVENTION; MINDFULNESS BASED STRESS REDUCTION; PARKINSON'S DISEASE;

AGED; AMYGDALA; BRAIN; BRAIN MAPPING; FEMALE; FOLLOW-UP STUDIES; FUNCTIONAL LATERALITY; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MINDFULNESS; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; STRESS, PSYCHOLOGICAL; TREATMENT OUTCOME; WATCHFUL WAITING;

EID: 84889888409     PISSN: 03038467     EISSN: 18726968     Source Type: Journal    
DOI: 10.1016/j.clineuro.2013.10.002     Document Type: Review

References (41)

1. J.P. Bach, U. Ziegler, G. Deuschl, R. Dodel, and G. Doblhammer-Reiter Projected numbers of people with movement disorders in the years 2030 and 2050 Mov Disord 26 October (12) 2011 2286 2290
2. S.H. Fox, R. Katzenschlager, S.Y. Lim, B. Ravina, K. Seppi, and M. Coelho The movement disorders society evidence-based review update: treatments for the motor symptoms of Parkinson's disease Mov Disord Suppl 3 October (26) 2011 S2 S41
3. K. Seppi, D. Weintraub, M. Coelho, S. Perez- Lloret, S.H. Fox, and R. Katzenschlager The movement disorders society evidence-based review update: treatments for the non-motor symptoms of Parkinson's disease Mov Disord Suppl 3 October (26) 2011 S42 S80
4. H. Braak, K. Del Tredici, U. Rüb, R.A. de Vos, E.N. Jansen Steur, and E. Braak Staging of brain pathology related to sporadic Parkinson's disease Neurobiol Aging 24 March-April (2) 2003 197 211
5. K. Jellinger Heterogeneous mechanisms of mild cognitive impairment in Parkinson's disease J Neural Transm 119 March (3) 2012 381 382
6. B. Ramirez-Ruiz, M.J. Marti, E. Tolosa, D. Bartrés-Faz, C. Summerfield, and P. Salgado-Pineda Longitudinal evaluation of cerebral morphological changes in Parkinson's disease with and without dementia J Neurol 252 November (11) 2005 52 1345
7. N. Ibarretxe-Bilbao, C. Junque, E. Tolosa, M.J. Marti, F. Valldeoriola, and N. Bargallo Neuroanatomical correlates of impaired decision-making and facial emotion recognition in early Parkinson's disease Eur J Neurosci 30 September (6) 2009 1162 1171
8. J. Pagonabarraga, I. Corcuera-Solano, Y. Vives-Gilabert, G. Liebaria, C. Garcia-Sánchez, and B. Pascual- Sedano Pattern of regional cortical thinning associated with cognitive deterioration in Parkinson's disease PloS One 8 1 2013 e54980
9. D. Crosiers, B. Pickut, J. Theuns, P.P. Deyn, C. Van Broeckhoven, and P. Martinez-Martin Non-motor symptoms in a Flanders-Belgian population of 215 Parkinson's disease patients as assessed by the Non-Motor Symptoms Questionnaire Am J Neurodegener Dis 1 2 2012 160 167
10. K.R. Chaudhuri, D.G. Healy, and A.H. Schapira National Institute for Clinical Excellence Non-motor symptoms of Parkinson's disease: diagnosis and management Lancet Neurol 5 March (3) 2006 235 245
11. D. Aarsland, K. Bronnick, C. Williams-Gray, D. Weintraub, K. Marder, and J. Kulisevsky Mild cognitive impairment in Parkinson's disease: a multicenter pooled analysis Neurology 75 September (12) 2010 1062 1069
12. I. Litvan, J.G. Goldman, A.I. Tröster, B.A. Schmand, D. Weintraub, and R.C. Petersen Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force Guidelines Mov Disord 27 March (3) 2012 349 356
13. L. Fitzpatrick, J. Simpson, and A. Smith A qualitative analysis of mindfulness-based cognitive therapy (MBCT) in Parkinson's disease Psychol Psychother 83 June (Pt 2) 2010 179 192
14. J. Kabat-Zinn Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain and Illness. 1990 Delta Publishing. New York NY. 140 146
15. J. Carmody, and R.A. Baer Relationships between mindfulness practice and levels of mindfulness, medical and psychological symptoms and well-being in a mindfulness-based stress reduction program J Behav Med 31 February (1) 2008 23 33
16. S.G. Hofmann, A.T. Sawyer, A.A. Witt, and D. Oh The effect of mindfulness therapy on anxiety and depression: a meta-analytic review J Consult Clin Psychol 78 April (2) 2010 169 183
17. L. Roemer, S.M. Orsillo, and K. Salters-Pedneault Efficacy of an acceptance-based behavior therapy for generalized anxiety disorder: evaluation in a randomized controlled trial J Consult Clin Psychol 76 December (6) 2008 1083 1089
18. J.D. Teasdale, Z.V. Segal, J.M. Williams, V.A. Ridgeway, J.M. Soulsby, and M.A. Lau Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy J Consult Clin Psychol 68 August (4) 2000 615 623
19. P. Grossman, U. Tiefenthaler-Gilmer, A. Raysz, and U. Kesper Mindfulness training as an intervention for fibromyalgia: evidence of postintervention and 3-year follow-up benefits in well-being Psychother Psychosom 76 4 2007 226 233
20. P. Grossman, L. Kappos, H. Gensicke, M. D'Souza, D.C. Mohr, and I.K. Penner MS Quality of Life, depression, and fatigue improve after mindfulness training: a randomized trial Neurology 75 September (13) 2010 1141 1149
21. S.W. Lazar, C.E. Kerr, R.H. Wasserman, J.R. Gray, D.N. Greve, and M.T. Treadway Meditation experience is associated with increased cortical thickness Neuroreport 16 November (17) 2005 1893 1897
22. G. Pagnoni, and M. Cekic Age effects on gray matter volume and attentional performance in Zen. meditation Neurobiol Aging 28 October (10) 2007 7 1623
23. B.K. Hölzel, U. Ott, T. Gard, H. Hempel, M. Weygandt, and K. Morgen Investigation of mindfulness meditation practitioners with voxel-based morphometry Soc Cogn Affect Neurosci 3 March (1) 2008 55 61
24. E. Luders, A.W. Toga, N. Lepore, and C. Gaser The underlying anatomical correlates of long-term. meditation: larger hippocampal and frontal volumes of gray matter Neuroimage 45 April (3) 2009 672 678
25. P. Vestergaard-Poulsen, M. van Beek, J. Skewes, C.R. Bjarkam, M. Stubberup, and J. Bertelsen Long-term meditation is associated with increased gray matter density in the brain stem Neuroreport 20 January (2) 2009 170 174
26. J.A. Grant, J. Courtemanche, E.G. Duerden, G.H. Duncan, and P. Rainville Cortical thickness and pain. sensitivity in zen meditators Emotion 10 February (1) 2010 43 53
27. B.K. Hölzel, J. Carmody, M. Vangel, C. Congleton, S.M. Yerramsetti, and T. Gard Mindfulness practice leads to increases in regional brain gray matter density Psychiatr Res 191 January (1) 2011 36 43
28. J. Ashburner, and K.J. Friston Unified segmentation Neuroimage 26 July (3) 2005 839 851
29. J. Ashburner A fast diffeomorphic image registration algorithm Neuroimage 38 October (1) 2007 95 113
30. L. Apostolova, G. Alves, K.S. Hwang, S. Babakchanian, K.S. Bronnick, and J.P. Larsen Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment Neurobiol Aging 33 September (9) 2012 2113 2124
31. E.J. Burton, I.G. McKeith, D.J. Burn, E.D. Williams, and J.T. O'Brien Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls Brain 127 April (Pt 4) 2004 791 800
32. J.D. Creswell, B.M. Way, N.L. Eisenberger, and M.D. Lieberman Neural correlates of dispositional mindfulness during affect labeling Psychosom Med 69 July-August (6) 2007 560 565
33. P.J. Gianaros, L.K. Sheu, K.A. Matthews, J.R. Jennings, S.B. Manuck, and A.R. Hariri Individual differences in stressor-evoked blood pressure reactivity vary with activation, volume, and functional connectivity of the amygdala J Neurosci 28 January (4) 2008 9 990
34. H. Murakami, T. Nakao, M. Matsunaga, Y. Kasuya, J. Shinoda, and J. Yamada The structure of mindful brain PloS One 7 9 2012 e46377
35. 2O PET study of meditation and the resting state of normal consciousness Hum Brain Mapp 7 2 1999 98 105
36. A.B. Newberg, N. Wintering, M.R. Waldman, D. Amen, D.S. Khalsa, and A. Alavi Cerebral blood flow differences between long-term meditators and non-meditators Conscious Cogn 19 December (4) 2010 899 905
37. M. Engström, and B. Söderfeldt Brain activation during compassion meditation: a case study J Altern Complement Med 16 May (5) 2010 597 599
38. C. Summerfield, C. Junqué, E. Tolosa, P. Salgado-Pineda, B. Gómez-Ansón, and M.J. Marti Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study Arch Neurol 62 February (2) 2005 281 285
39. E. Luders, F. Kurth, E.A. Mayer, A.W. Toga, K.L. Narr, and C. Gaser The unique brain anatomy of meditation practitioners: alterations in cortical gyrification Front Hum Neurosci 6 2012 34
40. T. Wu, and M. Hallett The cerebellum in Parkinson's disease Brain 136 March (Pt 3) 2013 696 709
41. D.G. MacCoon, Z.E. Imel, M.A. Rosenkranz, J.G. Sheftel, H.Y. Weng, and J.C. Sullivan The validation of an active control intervention for Mindfulness Based Stress Reduction (MBSR) Behav Res Ther 50 January (1) 2012 3 12