메뉴 건너뛰기




Volumn 56, Issue 10, 2013, Pages 567-576

The impact of a moderate chronic temperature increase on spleen immune-relevant gene transcription depends on whether Atlantic cod (Gadus morhua) are stimulated with bacterial versus viral antigens

Author keywords

Aeromonas salmonicida; Aquaculture; Atlantic cod (Gadus morhua); Microarray; Poly IC; Temperature; Viral

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ANTIGEN; FISH PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; TRANSCRIPTOME; VIRUS ANTIGEN;

EID: 84889824334     PISSN: 08312796     EISSN: None     Source Type: Journal    
DOI: 10.1139/gen-2013-0090     Document Type: Article
Times cited : (34)

References (39)
  • 1
    • 33845348139 scopus 로고    scopus 로고
    • Temperature-dependent protection against Ichthyophthirius multifiliis following immunisation of rainbow trout using live theronts
    • Alishahi M. Buchmann K. 2006. Temperature-dependent protection against Ichthyophthirius multifiliis following immunisation of rainbow trout using live theronts. Dis. Aquat. Org. 72: 269-273. 10.3354/dao072269. 17190205. (Pubitemid 44870868)
    • (2006) Diseases of Aquatic Organisms , vol.72 , Issue.3 , pp. 269-273
    • Alishahi, M.1    Buchmann, K.2
  • 2
    • 84875805099 scopus 로고    scopus 로고
    • Impaired TLR2 and TLR7 response in olive flounder infected with viral haemorrhagic septicaemia virus at host susceptible 15 C but high at non-susceptible 20 C
    • 10.1016/j.fsi.2013.02.012. 23462148.
    • Avunje S. Oh M.-J. Jung S.-J. 2013. Impaired TLR2 and TLR7 response in olive flounder infected with viral haemorrhagic septicaemia virus at host susceptible 15 C but high at non-susceptible 20 C. Fish Shellfish Immunol. 34: 1236-1243. 10.1016/j.fsi.2013.02.012. 23462148.
    • (2013) Fish Shellfish Immunol. , vol.34 , pp. 1236-1243
    • Avunje, S.1    Oh, M.-J.2    Jung, S.-J.3
  • 3
    • 84874957055 scopus 로고    scopus 로고
    • Aeromonas spp. Whole genomes and virulence factors implicated in fish disease
    • 10.1111/jfd.12025. 23305319.
    • Beaz-Hidalgo R. Figueras M.J. 2013. Aeromonas spp. Whole genomes and virulence factors implicated in fish disease. J. Fish Dis. 36: 371-388. 10.1111/jfd.12025. 23305319.
    • (2013) J. Fish Dis. , vol.36 , pp. 371-388
    • Beaz-Hidalgo, R.1    Figueras, M.J.2
  • 4
    • 67651152983 scopus 로고    scopus 로고
    • Proliferative kidney disease (PKD) of rainbow trout: Temperature-and time-related changes of Tetracapsuloides bryosalmonae DNA in the kidney
    • 10.1017/S0031182009005800.
    • Bettge K. Segner H. Burki R. Schmidt-Posthaus H. Wahli T. 2009. Proliferative kidney disease (PKD) of rainbow trout: temperature-and time-related changes of Tetracapsuloides bryosalmonae DNA in the kidney. Parasitolology, 136: 615-625. 10.1017/S0031182009005800.
    • (2009) Parasitolology , vol.136 , pp. 615-625
    • Bettge, K.1    Segner, H.2    Burki, R.3    Schmidt-Posthaus, H.4    Wahli, T.5
  • 5
    • 2342646842 scopus 로고    scopus 로고
    • LSimpute: Accurate estimation of missing values in microarray data with least squares methods
    • 10.1093/nar/gnh026. 14978222.
    • Bø T.H. Dysvik B. Jonassen I. 2004. LSimpute: accurate estimation of missing values in microarray data with least squares methods. Nucleic Acids Res. 32: e34. 10.1093/nar/gnh026. 14978222.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 34
    • Dysvik, B.1    Jonassen, I.2
  • 6
    • 79960453749 scopus 로고    scopus 로고
    • Development and experimental validation of a 20K Atlantic cod (Gadus morhua) oligonucleotide microarray based on a collection of over 150,000 ESTs
    • 10.1007/s10126-010-9335-6. 21127932.
    • Booman M. Borza T. Feng C.Y. Hori T.S. Higgins B. Culf A. et al 2011. Development and experimental validation of a 20K Atlantic cod (Gadus morhua) oligonucleotide microarray based on a collection of over 150,000 ESTs. Mar. Biotechnol. 13: 733-750. 10.1007/s10126-010-9335-6. 21127932.
    • (2011) Mar. Biotechnol. , vol.13 , pp. 733-750
    • Booman, M.1    Borza, T.2    Feng, C.Y.3    Hori, T.S.4    Higgins, B.5    Culf, A.6
  • 7
    • 77952882248 scopus 로고    scopus 로고
    • Atlantic cod (Gadus morhua) CC chemokines: Diversity and expression analysis
    • 10.1016/j.dci.2010.03.011. 20381521.
    • Borza T. Stone C. Rise M.L. Bowman S. Johnson S.C. 2010. Atlantic cod (Gadus morhua) CC chemokines: diversity and expression analysis. Dev. Comp. Immunol. 34: 904-913. 10.1016/j.dci.2010.03.011. 20381521.
    • (2010) Dev. Comp. Immunol. , vol.34 , pp. 904-913
    • Borza, T.1    Stone, C.2    Rise, M.L.3    Bowman, S.4    Johnson, S.C.5
  • 8
    • 77955434404 scopus 로고    scopus 로고
    • An integrated approach to gene discovery and marker development in Atlantic cod (Gadus morhua)
    • 10.1007/s10126-010-9285-z. 20396923.
    • Bowman S. Hubert S. Higgins B. Stone C. Kimball J. Borza T. et al 2011. An integrated approach to gene discovery and marker development in Atlantic cod (Gadus morhua). Mar. Biotechnol. 13 (2): 242-255. 10.1007/s10126-010-9285-z. 20396923.
    • (2011) Mar. Biotechnol. , vol.13 , Issue.2 , pp. 242-255
    • Bowman, S.1    Hubert, S.2    Higgins, B.3    Stone, C.4    Kimball, J.5    Borza, T.6
  • 9
    • 0242339678 scopus 로고    scopus 로고
    • Larviculture of Atlantic cod (Gadus morhua): Progress, protocols and problems
    • DOI 10.1016/S0044-8486(03)00514-3
    • Brown J.A. Minkoff G. Puvanendran V. 2003. Larviculture of Atlantic cod (Gadus morhua): progress, protocols and problems. Aquaculture, 227: 357-372. 10.1016/S0044-8486(03)00514-3. (Pubitemid 37353719)
    • (2003) Aquaculture , vol.227 , Issue.1-4 , pp. 357-372
    • Brown, J.A.1    Minkoff, G.2    Puvanendran, V.3
  • 10
    • 77249129377 scopus 로고    scopus 로고
    • Comparative analysis of missing value imputation methods to improve clustering and interpretation of microarray experiments
    • 10.1186/1471-2164-11-15. 20056002.
    • Celton M. Malpertuy A. Lelandais G. de Brevern A.G. 2010. Comparative analysis of missing value imputation methods to improve clustering and interpretation of microarray experiments. BMC Genomics, 11: 15. 10.1186/1471-2164-11-15. 20056002.
    • (2010) BMC Genomics , vol.11 , pp. 15
    • Celton, M.1    Malpertuy, A.2    Lelandais, G.3    De Brevern, A.G.4
  • 11
    • 24644503098 scopus 로고    scopus 로고
    • Blast2GO: A universal tool for annotation, visualization and analysis in functional genomics research
    • DOI 10.1093/bioinformatics/bti610
    • Conesa A. Götz S. García-Gómez J.M. Terol J. Talón M. Robles M. 2005. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics, 21 (18): 3674-3676. 10.1093/bioinformatics/bti610. 16081474. (Pubitemid 41264107)
    • (2005) Bioinformatics , vol.21 , Issue.18 , pp. 3674-3676
    • Conesa, A.1    Gotz, S.2    Garcia-Gomez, J.M.3    Terol, J.4    Talon, M.5    Robles, M.6
  • 12
    • 0031145345 scopus 로고    scopus 로고
    • Immunocompetence and duration of immunity against Vibrio salmonicida and Aeromonas salmonicida after vaccination of Atlantic salmon (Salmo salar L.) at low and high temperatures
    • Eggset G. Mikkelsen H. Killie J.-E.A. 1997. Immunocompetence and duration of immunity against Vibrio salmonicida and Aeromonas salmonicida after vaccination of Atlantic salmon (Salmo salar L.) at low and high temperatures. Fish Shellfish Immunol. 7: 247-260. 10.1006/fsim.1997.0080. (Pubitemid 127167907)
    • (1997) Fish and Shellfish Immunology , vol.7 , Issue.4 , pp. 247-260
    • Eggset, G.1    Mikkelsen, H.2    Killie, J.-E.A.3
  • 13
    • 84876123611 scopus 로고    scopus 로고
    • FAO FAO Fisheries and Aquaculture Technical Paper No. 569
    • FAO. 2011. Review of the state of the world marine fishery resources. FAO Fisheries and Aquaculture Technical Paper No. 569. Available from http://www.fao.org/docrep/015/i2389e/i2389e00.htm.
    • (2011) Review of the state of the world marine fishery resources
  • 14
    • 66349100829 scopus 로고    scopus 로고
    • Identification and analysis of differentially expressed genes in immune tissues of Atlantic cod stimulated with formalin-killed atypical Aeromonas salmonicida
    • 10.1152/physiolgenomics.90373.2008.
    • Feng C.Y. Johnson S.C. Hori T.S. Rise M. Hall J.R. Gamperl A.K. et al 2009. Identification and analysis of differentially expressed genes in immune tissues of Atlantic cod stimulated with formalin-killed atypical Aeromonas salmonicida. Physiol. Genomics, 37: 149-163. 10.1152/physiolgenomics.90373.2008.
    • (2009) Physiol. Genomics , vol.37 , pp. 149-163
    • Feng, C.Y.1    Johnson, S.C.2    Hori, T.S.3    Rise, M.4    Hall, J.R.5    Gamperl, A.K.6
  • 15
    • 33748420172 scopus 로고    scopus 로고
    • Cardiovascular and haematological responses of Atlantic cod (Gadus morhua) to acute temperature increase
    • DOI 10.1242/jeb.02319
    • Gollock M.J. Currie S. Petersen L.H. Gamperl A.K. 2006. Cardiovascular and haematological responses of Atlantic cod (Gadus morhua) to acute temperature increase. J. Exp. Biol. 209: 2961-2970. 10.1242/jeb.02319. 16857880. (Pubitemid 44342574)
    • (2006) Journal of Experimental Biology , vol.209 , Issue.15 , pp. 2961-2970
    • Gollock, M.J.1    Currie, S.2    Petersen, L.H.3    Gamperl, A.K.4
  • 17
    • 84863217774 scopus 로고    scopus 로고
    • Pathogen recognition and mechanims in Atlantic cod (Gadus morhua) head kidney cells: Bacteria (LPS) and virus (poly I:C) signals through different pathways and affect distinct genes
    • 10.1016/j.fsi.2012.05.013.
    • Holen E. Lie K.K. Araujo P. Olsvik P.A. 2012. Pathogen recognition and mechanims in Atlantic cod (Gadus morhua) head kidney cells: bacteria (LPS) and virus (poly I:C) signals through different pathways and affect distinct genes. Fish Shellfish Immunol. 33 (2): 267-276. 10.1016/j.fsi.2012.05.013.
    • (2012) Fish Shellfish Immunol. , vol.33 , Issue.2 , pp. 267-276
    • Holen, E.1    Lie, K.K.2    Araujo, P.3    Olsvik, P.A.4
  • 18
    • 84865317030 scopus 로고    scopus 로고
    • A moderate increase in ambient temperature modulates the Atlantic cod (Gadus morhua) spleen transcriptome response to intraperitoneal viral mimic injection
    • 10.1186/1471-2164-13-431. 22928584.
    • Hori T.S. Gamperl. A.K. Booman M. Nash G.W. Rise M.L. 2012. A moderate increase in ambient temperature modulates the Atlantic cod (Gadus morhua) spleen transcriptome response to intraperitoneal viral mimic injection. BMC Genomics, 13: 431. 10.1186/1471-2164-13-431. 22928584.
    • (2012) BMC Genomics , vol.13 , pp. 431
    • Hori, T.S.1    Gamperl, A.K.2    Booman, M.3    Nash, G.W.4    Rise, M.L.5
  • 19
    • 84864012182 scopus 로고    scopus 로고
    • Consequences of high temperatures and premature mortality on the transcriptome and blood physiology of wild adult sockey salmon (Onconrhynchus nerka)
    • 10.1002/ece3.274. 22957178.
    • Jeffries K.M. Hinch S.G. Sierocinski T. Clarck T.D. Eliason E.J. Donaldson M.R. et al 2012. Consequences of high temperatures and premature mortality on the transcriptome and blood physiology of wild adult sockey salmon (Onconrhynchus nerka). Ecol. Evol. 2 (7): 1747-1764. 10.1002/ece3.274. 22957178.
    • (2012) Ecol. Evol. , vol.2 , Issue.7 , pp. 1747-1764
    • Jeffries, K.M.1    Hinch, S.G.2    Sierocinski, T.3    Clarck, T.D.4    Eliason, E.J.5    Donaldson, M.R.6
  • 20
    • 33144489164 scopus 로고    scopus 로고
    • Gadoid mariculture: Development and future challenges
    • DOI 10.1016/j.icesjms.2005.12.003, PII S1054313905002377, Gadoid Mariculture: Development and Future Challenges
    • Kjesbu O.S. Taranger G.L. Trippel E.A. 2006. Gadoid mariculture: development and future challenges. ICES J. Mar. Sci. 63: 187-191. 10.1016/j.icesjms.2005.12.003. (Pubitemid 43265921)
    • (2006) ICES Journal of Marine Science , vol.63 , Issue.2 , pp. 187-191
    • Kjesbu, O.S.1    Taranger, G.L.2    Trippel, E.A.3
  • 21
    • 56949095701 scopus 로고    scopus 로고
    • Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); Vaccine efficacy and antibody responses
    • 10.1016/j.vaccine.2008.10.012. 18951938.
    • Lund V. Arnesen J.A. Mikkelsen H. Gravningen K. Brown L. Schrøder M.B. 2008. Atypical furunculosis vaccines for Atlantic cod (Gadus morhua); vaccine efficacy and antibody responses. Vaccine, 26: 6791-6799. 10.1016/j.vaccine.2008.10.012. 18951938.
    • (2008) Vaccine , vol.26 , pp. 6791-6799
    • Lund, V.1    Arnesen, J.A.2    Mikkelsen, H.3    Gravningen, K.4    Brown, L.5    Schrøder, M.B.6
  • 23
    • 81255136160 scopus 로고    scopus 로고
    • Temperature effects on immune response and hematological parameters of channel catfish Ictalurus punctatus vaccinated with live theronts of Ichthyophthirius multifilis
    • 10.1016/j.fsi.2011.07.015. 21791246.
    • Martins M.L. Xu D.H. Shoemaker C.A. Klesius P.H. 2011. Temperature effects on immune response and hematological parameters of channel catfish Ictalurus punctatus vaccinated with live theronts of Ichthyophthirius multifilis. Fish Shellfish Immunol. 31: 774-780. 10.1016/j.fsi.2011.07.015. 21791246.
    • (2011) Fish Shellfish Immunol. , vol.31 , pp. 774-780
    • Martins, M.L.1    Xu, D.H.2    Shoemaker, C.A.3    Klesius, P.H.4
  • 26
    • 84875810578 scopus 로고    scopus 로고
    • Temperature-induced transcription of inflammatory mediators and the influence of Hsp70 following LPS stimulation of southern bleufin tuna peripheral blood leukocytes and kidney homogenates
    • 23439399.
    • Polinski M. Bridle A. Nowak B. 2013. Temperature-induced transcription of inflammatory mediators and the influence of Hsp70 following LPS stimulation of southern bleufin tuna peripheral blood leukocytes and kidney homogenates. Fish Shellfish Immunol. 34: 1147-1157. 23439399.
    • (2013) Fish Shellfish Immunol. , vol.34 , pp. 1147-1157
    • Polinski, M.1    Bridle, A.2    Nowak, B.3
  • 27
    • 39149096050 scopus 로고    scopus 로고
    • Temperature-dependent expression of immune-relevant genes in rainbow trout following Yersinia ruckeri vaccination
    • DOI 10.3354/dao01808
    • Raida M.K. Buchmann K. 2007. Temperature-dependent expression of immune-relevant genes in rainbow trout following Yersinia ruckeri vaccination. Dis. Aquat. Org. 77: 41-52. 10.3354/dao01808. 17933396. (Pubitemid 351547085)
    • (2007) Diseases of Aquatic Organisms , vol.77 , Issue.1 , pp. 41-52
    • Raida, M.K.1    Buchmann, K.2
  • 28
    • 52949129891 scopus 로고    scopus 로고
    • The genome of Aeromonas salmonicida subsp salmonicida A449: Insights into the evolution of a fish pathogen
    • 10.1186/1471-2164-9-427.
    • Reith M.E. Singh R.K. Curtis B. Boyd J.M. Bouevitch A. Kimball J. et al 2008. The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen. BMC Genomics, 9: 727. 10.1186/1471-2164-9- 427.
    • (2008) BMC Genomics , vol.9 , pp. 727
    • Reith, M.E.1    Singh, R.K.2    Curtis, B.3    Boyd, J.M.4    Bouevitch, A.5    Kimball, J.6
  • 29
    • 40849111421 scopus 로고    scopus 로고
    • Functional genomic analysis of the response of Atlantic cod (Gadus morhua) spleen to the viral mimic polyriboinosinic polyribocytidylic acid (pIC)
    • 10.1016/j.dci.2008.01.002. 18325588.
    • Rise M.L. Hall J. Rise M. Hori T. Gamperl A.K. Kimball J. et al 2008. Functional genomic analysis of the response of Atlantic cod (Gadus morhua) spleen to the viral mimic polyriboinosinic polyribocytidylic acid (pIC). Dev. Comp. Immunol. 32: 916-931. 10.1016/j.dci.2008.01.002. 18325588.
    • (2008) Dev. Comp. Immunol. , vol.32 , pp. 916-931
    • Rise, M.L.1    Hall, J.2    Rise, M.3    Hori, T.4    Gamperl, A.K.5    Kimball, J.6
  • 30
    • 77955432901 scopus 로고    scopus 로고
    • Impact of asymptomatic nodavirus carrier state and intraperitoneal viral mimic injection on brain transcript expression in Atlantic cod (Gadus morhua)
    • 10.1152/physiolgenomics.00168.2009.
    • Rise M.L. Hall J.R. Rise M. Hori T.S. Browne M.J. Gamperl A.K. et al 2010. Impact of asymptomatic nodavirus carrier state and intraperitoneal viral mimic injection on brain transcript expression in Atlantic cod (Gadus morhua). Physiol. Genomics, 42: 266-280. 10.1152/physiolgenomics.00168.2009.
    • (2010) Physiol. Genomics , vol.42 , pp. 266-280
    • Rise, M.L.1    Hall, J.R.2    Rise, M.3    Hori, T.S.4    Browne, M.J.5    Gamperl, A.K.6
  • 31
    • 84861636969 scopus 로고    scopus 로고
    • 135 years of global ocean warming between the Challenger expedition and the Argo Programme
    • 10.1038/nclimate1461.
    • Roemmich D. Gould W.J. Gilson J. 2012. 135 years of global ocean warming between the Challenger expedition and the Argo Programme. Nature Climate Change, 2: 425-428. 10.1038/nclimate1461.
    • (2012) Nature Climate Change , vol.2 , pp. 425-428
    • Roemmich, D.1    Gould, W.J.2    Gilson, J.3
  • 33
    • 34347383553 scopus 로고    scopus 로고
    • Cod juvenile production: Research and commercial developments
    • DOI 10.1016/j.aquaculture.2007.04.040, PII S0044848607003663
    • Rosenlund G. Halldórsson Ó. 2007. Cod juvenile production: research and commercial developments. Aquaculture, 268: 188-194. 10.1016/j.aquaculture.2007.04.040. (Pubitemid 47023089)
    • (2007) Aquaculture , vol.268 , Issue.1-4 SPEC. ISS. , pp. 188-194
    • Rosenlund, G.1    Halldorsson, O.2
  • 34
    • 33144489892 scopus 로고    scopus 로고
    • Worldwide status and perspective on gadoid culture
    • DOI 10.1016/j.icesjms.2005.11.012, PII S1054313905002286, Gadoid Mariculture: Development and Future Challenges
    • Rosenlund G. Skretting M. 2006. Worldwide status and perspective on gadoid culture. ICES J. Mar. Sci. 63: 194-197. 10.1016/j.icesjms.2005.11.012. (Pubitemid 43265922)
    • (2006) ICES Journal of Marine Science , vol.63 , Issue.2 , pp. 194-197
    • Rosenlund, G.1    Skretting, M.2
  • 35
    • 33749415072 scopus 로고    scopus 로고
    • Viral and bacterial diseases of Atlantic cod Gadus morhua, their prophylaxis and treatment: A review
    • Samuelsen O.B. Nerland A.H. Jørgensen T. Schrøder M.B. Svåsand T. Bergh O. 2006. Viral and bacterial diseases of Atlantic cod Gadus morhua, their prophylaxis and treatment: a review. Dis. Aquat. Org. 71: 239-254. 10.3354/dao071239. 17058605. (Pubitemid 44500414)
    • (2006) Diseases of Aquatic Organisms , vol.71 , Issue.3 , pp. 239-254
    • Samuelsen, O.B.1    Nerland, A.H.2    Jorgensen, T.3    Schroder, M.B.4    Svasand, T.5    Bergh, O.6
  • 36
    • 35548994186 scopus 로고    scopus 로고
    • Characterisation and expression analysis of the interleukin genes, IL-1β, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.)
    • DOI 10.1016/j.molimm.2007.08.003, PII S0161589007006827
    • Seppola M. Larsen A.N. Steiro K. Robertsen B. Jensen I. 2008. Characterisation and expression analysis of the interleukin genes, IL-1β, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.). Mol. Immunol. 45: 887-897. 10.1016/j.molimm.2007.08.003. 17875325. (Pubitemid 350016346)
    • (2008) Molecular Immunology , vol.45 , Issue.4 , pp. 887-897
    • Seppola, M.1    Larsen, A.N.2    Steiro, K.3    Robertsen, B.4    Jensen, I.5
  • 37
    • 50149110932 scopus 로고    scopus 로고
    • Identification, cloning and expression analysis of a hepcidin cDNA of the Atlantic cod (Gadus morhua L.)
    • 10.1016/j.fsi.2008.05.013. 18602479.
    • Solstad T. Larsen A.N. Seppola M. Jørgensen T.Ø. 2008. Identification, cloning and expression analysis of a hepcidin cDNA of the Atlantic cod (Gadus morhua L.). Fish Shellfish Immunol. 25: 298-310. 10.1016/j.fsi.2008.05.013. 18602479.
    • (2008) Fish Shellfish Immunol. , vol.25 , pp. 298-310
    • Solstad, T.1    Larsen, A.N.2    Seppola, M.3    Jørgensen T.Ø4
  • 39
    • 22144450706 scopus 로고    scopus 로고
    • Husbandry stress during early life stages affects the stress response and health status of juvenile sea bass, Dicentrarchus labrax
    • DOI 10.1016/j.fsi.2005.04.005, PII S1050464805000859
    • Varsamos S. Flik G. Pepin J.F. Wendelaar Bonga S.E. Breuil G. 2006. Husbandry stress during early life stages affects the stress response and health status of juvenile sea bass, Dicentrarchus labrax. Fish Shellfish Immunol. 20: 83-96. 10.1016/j.fsi.2005.04.005. 15961320. (Pubitemid 40968384)
    • (2006) Fish and Shellfish Immunology , vol.20 , Issue.1 , pp. 83-96
    • Varsamos, S.1    Flik, G.2    Pepin, J.F.3    Bonga, S.E.W.4    Breuil, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.