The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer

Diagnostic Pathology

Volumn 8, Issue 1, 2013, Pages

  Geng, Ming ^a   Wang, Lin ^a   Chen, Xin ^a   Cao, Ruixue ^a   Li, Peifeng ^a  

^a JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

Drug sensitivity; Gastric cancer; GST ; MTT colorimetric assay; Pgp; Topo II

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CISPLATIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; DRUG DERIVATIVE; FLUOROURACIL; GLUTATHIONE TRANSFERASE P1; HOMOCAMPTOTHECIN; MITOMYCIN; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CELL CULTURE; DRUG EFFECT; DRUG RESISTANCE; HUMAN; IN VITRO STUDY; METABOLISM; PATHOLOGY; STOMACH; STOMACH TUMOR;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELLS, CULTURED; CISPLATIN; DNA TOPOISOMERASES, TYPE II; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MITOMYCIN; P-GLYCOPROTEIN; STOMACH; STOMACH NEOPLASMS;

EID: 84889822268     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-8-198     Document Type: Article

References (19)

1. Perez-Tomas R. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem 2006, 13(16):1859-1876. 10.2174/092986706777585077, 16842198.
2. Leonard GD, Fojo T, Bates SE. The role of ABC transporters in clinical practice. Oncologist 2003, 8(5):411-424. 10.1634/theoncologist.8-5-411, 14530494.
3. Zhang Y, Zhou T, Duan J, Xiao Z, Li G, Xu F. Inhibition of P-glycoprotein and Glutathione S-transferase-pi mediated resistance by fluoxetine in MCF-7/ADM cells. Biomed Pharmacother 2013, 67(8):757-762. 10.1016/j.biopha.2013.04.012, 23731711.
4. Ganapathi RN, Ganapathi MK. Mechanisms regulating resistance to inhibitors of topoisomerase II. Front Pharmacol 2013, 4:89. 3729981, 23914174.
5. Wang L, Li PF, Geng M, Cao YC, Yin YC. Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. Diagn Pathol 2013, 8:33. 10.1186/1746-1596-8-33, 3599120, 23432846.
6. Liang ZY, Wang WZ, Gao J, Wu SF, Zeng X, Liu TH. Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas. Zhonghua Bing Li Xue Za Zhi 2007, 36(2):102-106.
7. Liu X, Xiong H, Li J, He Y, Yuan X. Correlation of hK6 expression with tumor recurrence and prognosis in advanced gastric cancer. Diagn Pathol 2013, 8:62. 10.1186/1746-1596-8-62, 3674969, 23587030.
8. Guan Z, Zhang J, Song S, Dai D. Promoter methylation and expression of TIMP3 gene in gastric cancer. Diagn Pathol 2013, 8(1):110. 10.1186/1746-1596-8-110, 3737241, 23819566.
9. Sotoudeh K, Hashemi F, Madjd Z, Sadeghipour A, Molanaei S, Kalantary E. The clinicopathologic association of c-MET overexpression in Iranian gastric carcinomas; an immunohistochemical study of tissue microarrays. Diagn Pathol 2012, 7:57. 10.1186/1746-1596-7-57, 3408322, 22640970.
10. Jin J, Jin T, Quan M, Piao Y, Lin Z. Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma. Diagn Pathol 2012, 7:135. 10.1186/1746-1596-7-135, 3502371, 23039327.
11. Pajic M, Iyer JK, Kersbergen A, van der Burg E, Nygren AO, Jonkers J, Borst P, Rottenberg S. Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res 2009, 69(16):6396-6404. 10.1158/0008-5472.CAN-09-0041, 19654309.
12. Pajeva IK, Sterz K, Christlieb M, Steggemann K, Marighetti F, Wiese M. Interactions of the multidrug resistance modulators tariquidar and Elacridar and their analogues with P-glycoprotein. Chem Med Chem 2013, doi: 10.1002/cmdc.201300233. [Epub ahead of print]).
13. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005, 205(2):275-292. 10.1002/path.1706, 15641020.
14. Loscher W, Potschka H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. Neuro Rx 2005, 2(1):86-98. 10.1602/neurorx.2.1.86, 539326, 15717060.
15. Triller N, Korosec P, Kern I, Kosnik M, Debeljak A. Multidrug resistance in small cell lung cancer: expression of P-glycoprotein, multidrug resistance protein 1 and lung resistance protein in chemo-naive patients and in relapsed disease. Lung Cancer 2006, 54(2):235-240. 10.1016/j.lungcan.2006.06.019, 16934363.
16. Pakos EE, Ioannidis JP. The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. Cancer 2003, 98(3):581-589. 10.1002/cncr.11546, 12879476.
17. Gate L, Majumdar RS, Lunk A, Tew KD. Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice. Int J Cancer 2005, 113(1):29-35. 10.1002/ijc.20540, 15386426.
18. Soh Y, Goto S, Kitajima M, Moriyama S, Kotera K, Nakayama T, Nakajima H, Kondo T, Ishimaru T. Nuclear localisation of glutathione S-transferase pi is an evaluation factor for drug resistance in gynaecological cancers. Clin Oncol (R Coll Radiol) 2005, 17(4):264-270. 10.1016/j.clon.2004.11.008, 15997922.
19. Nielsen D, Maare C, Skovsgaard T. Cellular resistance to anthracyclines. Gen Pharmacol 1996, 27(2):251-255. 10.1016/0306-3623(95)02013-6, 8919638.