Histology of Cystic Tumors of the Pancreas

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery: Second Edition

Volumn , Issue , 2009, Pages 891-911

  Kimura, Wataru ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Anterior superior pancreaticoduodenal (ASPD) artery and anterior inferior pancreaticoduodenal (AIPD) artery; Cystic lesions of pancreas diagnosed by ultrasonography or abdominal computed tomography (CT); Cystic tumor histology of pancreas; Endoscopic retrograde cholangiopancreatography (ERCP); Epithelial proliferative lesions and age; Magnetic resonance cholangiopancreatography of branch type intraductal papillary mucinous neoplasm; Mucinous cystic neoplasm (MCN); Spleen preserving distal pancreatectomy; Therapeutic strategies

Indexed keywords

EID: 84889764628     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444300123.ch97     Document Type: Chapter

References (61)

1. Howard JM, Jordan GL Jr. Pancreatic cysts. In: Howard JM and Jordan GL Jr, eds. Surgical Diseases of the Pancreas. Philadelphia:Lippincott, 1960: 283.
2. Strodel WE, Eckhauser FE. Cystic neoplasms of the pancreas. In:Dent TL, ed. Pancreatic Disease. Diagnosis and Therapy. New York: Grune & Stratton, 1981: 363.
3. Cubilla AL, Fitzgerald PJ. Cysts. In: Cubilla A and Fitzgerald JP, eds. Tumors of the Exocrine Pancreas, 2nd edn. Washington, DC:Armed Forces Institute of Pathology, 1984: 60-3.
4. Bradley EL III. Cysts and pseudocysts of the pancreas. Surgical aspects. In: Berk JE, ed. Gastroenterology, Vol. 6. Philadelphia, WB Saunders, 1985: 4151.
5. Howard JM. Cysts of the pancreas. In: Howard JM, Jordan GL Jr and Reber HA, eds. Surgical Disease of the Pancreas. Philadelphia: Lea & Febiger, 1987: 539-63.
6. Kuroda A, Morioka M. Recent trends in cystic diseases of the pancreas: classification and problems. Tan to Sui 1990;11:1-8.
7. Kimura W, Makuuchi M. Operative indications for cystic lesions of the pancreas with malignant potential: our experience. Hepatogastroenterology 1999;46:483-91.
8. Kimura W, Inoue T, Futakawa N, Shinkai H, Han I, Muto T. Spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein. Surgery 1996;120:885-90.
9. Kimura W, Nagai H. Study of surgical anatomy for duodenumpreserving resection of the head of the pancreas. Ann Surg 1995;221:359-63.
10. Kimura W. Cystic tumors of the pancreas: diagnosis and therapy. Yamagata Med J 2000;18:97-107.
11. Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573-80.
12. Matsuno S, Egawa S, Shibuya K et al. Pancreatic cancer: current status of treatment and survival of 16 071 patients diagnosed from 1981-1996, using the Japanese National Pancreatic Cancer Database. Int J Clin Oncol 2000;5:153-7.
13. Suzuki Y, Atomi Y, Sugiyama M et al. Analysis and problems of multi-institutional studies of intraductal papillary mucinous tumor and mucinous cystic tumors [Japanese with English abstract]. J Jpn Pancreas Soc 2003;18:653-63.
14. Suzuki Y, Atomi Y, Sugiyama M et al. Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor. Pancreas 2004;28:241-6.
15. Falconi M, Salvia R, Bassi C, Zamboni G, Talamini G, Pederzoli P. Clinicopathological features and treatment of intraductal papillary mucinous tumour of the pancreas. Br J Surg 2001;88:376-81.
16. Kimura W, Futakawa N, Morikane K et al. Operative indication for cystic lesions of the pancreas [Japanese]. Geka 1995;57:767-76.
17. Kimura W. Pathological and clinical findings of the cystic tumor of the pancreas [Japanese]. Medical Practice 2001;18:961-6.
18. Kimura W. IHPBA in Tokyo, 2002. Surgical treatment of IPMT vs MCT: a Japanese experience. J Hepatobiliary Pancreat Surg 2003;10:156-62.
19. Kimura W, Fuse A, Hirai I, Kamiga M. Problems in the diagnosis and treatment of cystic lesions of the pancreas [Japanese with English abstact]. J Jpn Pancreas Soc 2003;18:644-52.
20. Kimura W, Sasahira N, Yoshikawa T, Muto T, Makuuchi M. Duct-ectatic type of mucin producing tumor of the pancreas: new concept of pancreatic neoplasia. Hepatogastroenterology 1996; 43:692-709.
21. Kimura W, Kuroda A, Makuuchi M. Problems in the diagnosis and treatment of a so-called mucin-producing tumor of the pancreas. Pancreas 1998;16:363-9.
22. Kimura W, Makuuchi M, Kuroda A. Characteristics and treatment of mucin-producing tumor of the pancreas. Hepatogastroenterology 1998;45:2001-8.
23. Kimura W. Mucin-producing tumors of the pancreas. Yamagata Med J 2000;18:91-5.
24. Maguchi H, Osanai M, Yanagawa N et al. Therapeutic strategy for mucin-producing tumor of the pancreas [Japanese]. Geka 1998;60:1152-7.
25. Japan Pancreas Society. Classification of Pancreatic Carcinoma, 2nd English edn. Tokyo: Kanehara & Co., 2003.
26. Kimura W. IPMT and MCT. In: Makuuchi M and Kimura W, eds. Knack and pitfalls of the diseases of the pancreas and spleen. Tokyo: Bunko-do, 2002: 48-50.
27. Kimura W. Surgical anatomy of the pancreas for limited resection. J Hepatobiliary Pancreat Surg 2000;7:473-9.
28. Kimura W, Muto T, Makuuchi M, Nagai H. Subtotal resection of the head of the pancreas preserving duodenum and vessels of pancreatic arcade. Hepatogastroenterology 1996;43:1438-41.
29. Yamaguchi K, Ohuchida J, Ohtsuka T, Nakano K, Tonaka M. Intraductal papillary mucinous tumor of the pancreas concomitant with ductal carcinomas of the pancreas. Pancreatology 2002;2:484-90.
30. Moriya T, Kimura W, Sakurai F et al. Minute invasive ductal carcinoma of the residual pancreas after distal pancreatectomy for intraductal papillary-mucinous tumor. Int J Gastrointest Cancer 2002;31:191-7.
31. Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 1999;94:470-3.
32. Kimura W, Fuse A, Hirai I et al. Spleen-preserving distal pancreatectomy with preservation of the splenic artery and vein for intraductal papillary-mucinous tumor (IPMT). Three interesting cases. Hepatogastroenterology 2003;50:2242-5.
33. Govil S, Imrie CW. Value of splenic preservation during distal pancreatectomy for chronic pancreatitis. Br J Surg 1999;86:895-8.
34. White SA, Sutton CD, Weymss-Holden S et al. The feasibility of spleen-preserving pancreatectomy for end-stage chronic pancreatitis. Am J Surg 2000;179:294-7.
35. Zamboni G, Scarpa A, Bogina G et al. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 1999;23:410-22.
36. Kimura W, Nomura T, Mizutani M, Jinfeng Ma, Hirai I, Fuse A. Definition of MCN (mucinous cystic neoplasm of the pancreas) and a proposal for a new concept of MRN or MSN (mucinous round or spherical neoplasm). Hepatogastroenterology (in press).
37. Tsuchiya R, Tsunoda T, Ishida T et al. Resection for cancer of the pancreas: the Japanese experience. Clin Gastroenterol 1990;4:931-9.
38. Trede M, Schwall G, Saeger HD. Survival after pancreaticoduodenectomy:118 resections without an operable mortality. Ann Surg 1990;211:447-58.
39. Yeo CJ, Cameron JL, Lillimoe KD et al. Pancreaticoduodenectomy for cancer of the head of the pancreas: 201 patients. Ann Surg 1995;221:721-33.
40. Ishikawa O, Ohigashi H, Sasaki Y et al. Practical grouping of positive lymph nodes in pancreatic head cancer treated by an extended pancreatectomy. Surgery 1997;121:640-5.
41. Kimura W, Nagai H, Kuroda A et al. Analysis of small cystic lesions of the pancreas. Int J Pancreatol 1995;18:197-206.
42. Kimura W, Morikane K, Esaki Y et al. Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy. Cancer 1998;82:1839-49.
43. Komatsu K. Pancreatographical and histopathological study of dilations of the pancreas ductules with special references to cystic dilatations. Juntendo Med J 1974;19:250-69.
44. Hruban RH, Wilentz RE, Kern SE. Genetic progression in the pancreatic ducts. Am J Pathol 2000;156:1821-5.
45. Kimura W, Ohtsubo K. Incidence, sites of origin, and immunohistochemical and histochemical characteristics of atypical epithelium and minute carcinoma of the papilla of Vater. Cancer 1988;61:1394-402.
46. Kimura W, Shimada H, Kuroda A et al. Carcinoma of the gallbladder and extrahepatic bile duct in autopsy cases of the aged, with special reference to its relationship to gallstones. Am J Gastroenterol 1989;84:386-90.
47. Kimura W. Histological study on pathogenesis of sites of isolated islets of Langerhans and their course to the terminal state. Am J Gastroenterol 1989;84:517-22.
48. Kimura W, Kuroda A, Morioka Y. Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy cases. Dig Dis Sci 1991;36:933-42.
49. Kimura W, Sata N, Nakayama H et al. Pancreatic carcinoma accompanied by pseudocyst: report of two cases. J Gastroenterol 1994;29:786-91.
50. Sommers SC, Murphy SA, Warren S. Pancreatic duct hyperplasia and cancer. Gastroenterology 1954;27:629-40.
51. Cubilla AL, Fitzgerald PJ. Morphological patterns of primary nonendocrine human pancreas carcinoma. Cancer Res 1975;35:2234-48.
52. Pour PM, Sayed S, Sayed G. Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases. Am J Clin Pathol 1982;77:137-52.
53. Kozuka S, Sassa R, Taki T et al. Relation of pancreatic duct hyperplasia to carcinoma. Cancer 1979;43:1418-28.
54. Hruban RH, Adsay NV, Albores-Saavedra J et al. Pancreatic intraepithelial neoplasia. A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001;25:579-86.
55. Luttges J, Reinecke-Luthge A, Mollmann B et al. Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 1999; 435:461-8.
56. Luttges J, Galehdari H, Brocker V et al. Alleic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 2001;158:1677-83.
57. Rickaert F, Cremer M, Deviere J et al. Intraductal mucinhypersecreting neoplasms of the pancreas. A clinicopathological study of eight patients. Gastroenterology 1991;101:512-19.
58. Kloeppel G, Solcia E, Longnecker DS et al. eds. World Health Organization International Histological Classification of Tumours. Histological Typing of Tumors of the Exocrine Pancreas, 2nd edn. Berlin: Springer-Verlag, 1998.
59. Solcia E, Capella C, Kloeppel G, eds. Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology, 1997.
60. Moriya T, Kimura W, Semba S et al. Biological similarities and differences between pancreatic intraepithelial neoplasias and intraductal papillary mucinous neoplasms. Int J Gastrointest Cancer 2005;35:111-19.
61. Kimura W. How many millimeters do atypical epithelia of the pancreas spread intraductally before beginning to infiltrate? Hepatogastroenterology 2003;50:2218-24.