Maltase-glucoamylase modulates gluconeogenesis and sucrase-isomaltase dominates starch digestion glucogenesis

Journal of Pediatric Gastroenterology and Nutrition

Volumn 57, Issue 6, 2013, Pages 704-712

  Diaz Sotomayor, Maricela ^a   Quezada Calvillo, Roberto ^a   Avery, Stephen E ^a   Chacko, Shaji K ^a   Yan, Li Ke ^b   Lin, Amy Hui Mei ^b   Ao, Zi Hua ^b   Hamaker, Bruce R ^b   Nichols, Buford L ^a  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Glucogenesis from starch; Gluconeogenesis; Glucose homeostasis; Maltase glycoamylase; Starch digestion; Sucrase isomaltase

Indexed keywords

ALPHA GLUCOSIDASE; CARBOHYDRATE; GLUCOSE; SUCRASE ISOMALTASE;

ANIMAL EXPERIMENT; ARTICLE; DIGESTION; FEEDING; FOOD INTAKE; GLUCOGENESIS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGENOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; STARCH DIGESTION;

MUS;

ALPHA-GLUCOSIDASES; ANIMALS; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; DIGESTION; GLUCONEOGENESIS; GLUCOSE; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; MICE, KNOCKOUT; MUTATION; POSTPRANDIAL PERIOD; STARCH; SUCRASE-ISOMALTASE COMPLEX;

EID: 84889657741     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3182a27438     Document Type: Article

References (24)

1. Quezada-Calvillo R, Robayo-Torres CC, Opekum AR, et al. Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis. J Nutr 2007;137:1725-33. (Pubitemid 47037698)
2. Robyt JF, French D. Multiple attack hypothesis of alpha-amylase action. Action of porcine pancreatic, human salivary, and Aspergillus oryzae alpha-amylases. Arch Biochem Biophys 1967;122:8-16.
3. Robyt JF, French D. Action pattern of porcine pancreatic alpha-amylase in relationship to substrate binding site of enzyme. J Biol Chem 1970; 245:3917-27.
4. Nichols BL, Quezada-Calvillo R, Robayo-Torres CC, et al. Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homestasis of mice. J Nutr 2009;139:684-90.
5. Brayer GD, Sidhu G, Maurus R, et al. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry 2000;39:4778-91. (Pubitemid 30225343)
6. Dahlqvist A. Disaccharide intolerance. JAMA 1966;195:225-7.
7. Dahlqvist A, Auricchio S, Semenza G, et al. Human intestinal disaccharidases and hereditary disaccharide intolerance. The hydrolysis of sucrose, isomaltose, palatinose (isomaltulose), and a-1,6-alphaoligosaccharide (isomalto-oligosaccharide) preparation. J Clin Invest 1963;42:556-62.
8. Dahlqvist A. Specificity of the human intestinal disaccharidases and implications for hereditary disaccharide intolerance. J Clin Invest 1962;41:463-9.
9. Auricchio S, Semenza G, Rubino A. Multiplicity of human intestinal disaccharidases II. Characterization of the individual maltases. Biochim Biophys Acta 1965;96:498-507.
10. Semenza G, Auricchio S, Rubino A. Multiplicity of human intestinal disaccharidases I. Chromatographic separation of maltases and of two lactases. Biochim Biophys Acta 1965;96:487-97.
11. Nichols BL, Eldering J, Avery S, et al. Human small intestinal maltaseglucoamyasec DNA cloning. Homology to sucrase-isomaltase. J Biol Chem 1998;273:3076-81.
12. Nichols BL, Avery S, Sen P, et al. The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities. Proc Natl Acad Sci U S A 2003;100:1432-7. (Pubitemid 36184019)
13. Englyst HN, Kingman SM, Cummings JH. Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr 1992;46 (suppl 2):S33-50.
14. Quezada-Calvillo R, Robayo-Torres CC, Ao Z, et al. Luminal substrate "brake" on mucosal maltase-glucoamylase activity regulates total rate of starch digestion to glucose. J Pediatr Gastroenterol Nutr 2007;45:32-43. (Pubitemid 47012328)
15. Quezada-Calvillo R, Sim L, Ao Z, et al. Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. J Nutr 2008;138:685-92. (Pubitemid 351469410)
16. Lin AH, Nichols BL, Quezada-Calvillo R, et al. Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal a-glucosidase subunit. PLoS One 2012;7:e35473.
17. van Dijk TH, Boer TS, Havinga R, et al. Quantification of hepatic carbohydrate metabolism in conscious mice using serial blood and urine spots. Anal Biochem 2003;322:1-13. (Pubitemid 37188550)
18. Chacko SK, Haymond MW, Sun Y, et al. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab 2012;302:E1055-62.
19. Anderson GH, Cho CE, Akhavan T, et al. Relation between estimates of cornstarch digestibility by the Englyst in vitro method and glycemic response, subjective appetite, and short-term food intake in young men. Am J Clin Nutr 2010;91:932-9.
20. Rosen LA, Ostman EM, Bjorck IM. Effects of cereal breakfasts on postprandial glucose, appetite regulation and voluntary energy intake at a subsequent standardized lunch; focusing on rye products. Nutr J 2011;10:7.
21. Bodinham CL, Frost GS, Robertson MD. Acute ingestion of resistant starch reduces food intake in healthy adults. Br J Nutr 2010;103: 917-22.
22. So PW, Yu WS, Kuo YT, et al. Impact of resistant starch on body fat patterning and central appetite regulation. PLoS One 2007;2:e1309.
23. Brites CM, Trigo MJ, Carrapico B, et al. Maize and resistant starch enriched breads reduce postprandial glycemic responses in rats. Nutr Res 2011;31:302-8.
24. Gray GM. Starch digestion and absorption in nonruminants. J Nutr 1992;122:172-7.